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Lypd6b LY6/PLAUR domain containing 6B [ Mus musculus (house mouse) ]

Gene ID: 71897, updated on 5-Mar-2024

Summary

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Official Symbol
Lypd6bprovided by MGI
Official Full Name
LY6/PLAUR domain containing 6Bprovided by MGI
Primary source
MGI:MGI:1919147
See related
Ensembl:ENSMUSG00000026765 AllianceGenome:MGI:1919147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310010M24Rik
Summary
Predicted to enable acetylcholine receptor regulator activity. Predicted to be located in plasma membrane. Predicted to be anchored component of membrane. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; notochord; and urinary system. Orthologous to human LYPD6B (LY6/PLAUR domain containing 6B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 3.8), cortex adult (RPKM 2.3) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Lypd6b in Genome Data Viewer
Location:
2 C1.1; 2 28.74 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (49677380..49838861)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (49787340..49948849)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49307666-49307775 Neighboring gene STARR-positive B cell enhancer ABC_E807 Neighboring gene STARR-seq mESC enhancer starr_04442 Neighboring gene enhancer of polycomb homolog 2 Neighboring gene kinesin family member 5C Neighboring gene STARR-positive B cell enhancer mm9_chr2:49589986-49590287 Neighboring gene STARR-seq mESC enhancer starr_04444 Neighboring gene predicted gene, 46738 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49672814-49673015 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49703331-49703484 Neighboring gene STARR-seq mESC enhancer starr_04445 Neighboring gene LY6/PLAUR domain containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E5915 Neighboring gene STARR-positive B cell enhancer ABC_E9514 Neighboring gene methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria Neighboring gene predicted gene 13483

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
  2. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Accumulation of beta-Amyloid Leads to a Decrease in Lynx1 and Lypd6B Expression in the Hippocampus and Increased Expression of Proinflammatory Cytokines in the Hippocampus and Blood Serum.
    Title: Accumulation of β-Amyloid Leads to a Decrease in Lynx1 and Lypd6B Expression in the Hippocampus and Increased Expression of Proinflammatory Cytokines in the Hippocampus and Blood Serum.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC143485

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine receptor regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine receptor regulator activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ly6/PLAUR domain-containing protein 6B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379381.1 → NP_001366310.1  ly6/PLAUR domain-containing protein 6B precursor

    Status: VALIDATED

    Source sequence(s)
    AL806528, AL929069, BX813318
    UniProtKB/Swiss-Prot
    A0JNT6, Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:40 → 144
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

  2. NM_001379382.1 → NP_001366311.1  ly6/PLAUR domain-containing protein 6B precursor

    Status: VALIDATED

    Source sequence(s)
    AL806528, AL929069, BX813318
    UniProtKB/Swiss-Prot
    A0JNT6, Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:40 → 144
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

  3. NM_001379383.1 → NP_001366312.1  ly6/PLAUR domain-containing protein 6B precursor

    Status: VALIDATED

    Source sequence(s)
    AL806528, AL929069, BX813318
    UniProtKB/Swiss-Prot
    A0JNT6, Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:40 → 144
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

  4. NM_001379384.1 → NP_001366313.1  ly6/PLAUR domain-containing protein 6B precursor

    Status: VALIDATED

    Source sequence(s)
    AL806528, AL929069, BX813318
    UniProtKB/Swiss-Prot
    A0JNT6, Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:40 → 144
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

  5. NM_001379385.1 → NP_001366314.1  ly6/PLAUR domain-containing protein 6B precursor

    Status: VALIDATED

    Source sequence(s)
    AL806528, AL929069, BX813318
    UniProtKB/Swiss-Prot
    A0JNT6, Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:40 → 144
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

  6. NM_001379386.1 → NP_001366315.1  ly6/PLAUR domain-containing protein 6B precursor

    Status: VALIDATED

    Source sequence(s)
    AL806528, AL929069, BX813318
    UniProtKB/Swiss-Prot
    A0JNT6, Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:40 → 144
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

  7. NM_001379387.1 → NP_001366316.1  ly6/PLAUR domain-containing protein 6B precursor

    Status: VALIDATED

    Source sequence(s)
    AL806528, AL929069, BX813318
    UniProtKB/Swiss-Prot
    A0JNT6, Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:40 → 144
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

  8. NM_027990.4 → NP_082266.2  ly6/PLAUR domain-containing protein 6B precursor

    Status: VALIDATED

    Source sequence(s)
    AL806528, AL929069, BX813318
    Consensus CDS
    CCDS16025.1
    UniProtKB/Swiss-Prot
    A0JNT6, Q9D7F2
    Related
    ENSMUSP00000028103.8, ENSMUST00000028103.13
    Conserved Domains (1) summary
    pfam16975
    Location:40 → 144
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    49677380..49838861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498352.5 → XP_006498415.1  ly6/PLAUR domain-containing protein 6B isoform X1

    See identical proteins and their annotated locations for XP_006498415.1

    UniProtKB/Swiss-Prot
    Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:59 → 163
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

  2. XM_006498350.5 → XP_006498413.1  ly6/PLAUR domain-containing protein 6B isoform X1

    See identical proteins and their annotated locations for XP_006498413.1

    UniProtKB/Swiss-Prot
    Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:59 → 163
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

  3. XM_006498351.5 → XP_006498414.1  ly6/PLAUR domain-containing protein 6B isoform X1

    See identical proteins and their annotated locations for XP_006498414.1

    UniProtKB/Swiss-Prot
    Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:59 → 163
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

  4. XM_006498353.5 → XP_006498416.1  ly6/PLAUR domain-containing protein 6B isoform X1

    See identical proteins and their annotated locations for XP_006498416.1

    UniProtKB/Swiss-Prot
    Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:59 → 163
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

  5. XM_006498354.5 → XP_006498417.1  ly6/PLAUR domain-containing protein 6B isoform X1

    See identical proteins and their annotated locations for XP_006498417.1

    UniProtKB/Swiss-Prot
    Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:59 → 163
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

  6. XM_017319267.1 → XP_017174756.1  ly6/PLAUR domain-containing protein 6B isoform X1

    UniProtKB/Swiss-Prot
    Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:59 → 163
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

  7. XM_006498359.5 → XP_006498422.1  ly6/PLAUR domain-containing protein 6B isoform X2

    See identical proteins and their annotated locations for XP_006498422.1

    UniProtKB/Swiss-Prot
    A0JNT6, Q9D7F2
    Conserved Domains (1) summary
    pfam16975
    Location:40 → 144
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7F2.2 GenPept UniProtKB/Swiss-Prot:Q9D7F2

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