U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cdadc1 cytidine and dCMP deaminase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 71891, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Cdadc1provided by MGI
Official Full Name
cytidine and dCMP deaminase domain containing 1provided by MGI
Primary source
MGI:MGI:1919141
See related
Ensembl:ENSMUSG00000021982 AllianceGenome:MGI:1919141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NYD-SP15; 2310010M10Rik
Summary
Predicted to enable several functions, including cytidine deaminase activity; importin-alpha family protein binding activity; and protein homodimerization activity. Predicted to be involved in DNA cytosine deamination and cytidine deamination. Predicted to be located in cytoplasm and nucleus. Orthologous to human CDADC1 (cytidine and dCMP deaminase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 3.1), frontal lobe adult (RPKM 2.8) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cdadc1 in Genome Data Viewer
Location:
14 C3; 14 31.48 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (59796837..59835433, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (59559386..59597985, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45935 Neighboring gene SET domain, bifurcated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4112 Neighboring gene calcium binding protein 39-like Neighboring gene aldo-keto reductase family 1, member B8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36842 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene shisa family member 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. NYD-SP15: a novel gene potentially involved in regulating testicular development and spermatogenesis. Liu Q, et al. Biochem Genet, 2006 Oct. PMID 16955368
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NYD-SP15 protein plays an important role in testicular development and spermatogenesis
    Title: NYD-SP15: a novel gene potentially involved in regulating testicular development and spermatogenesis.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cytidine deaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables dCMP deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables importin-alpha family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA cytosine deamination ISO
Inferred from Sequence Orthology
more info
  
involved_in cytidine deamination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytidine deamination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cytidine and dCMP deaminase domain-containing protein 1
Names
cytidine deaminase
NP_001162007.1
NP_001162008.1
NP_001162009.1
NP_001162010.1
NP_082262.1
XP_011243506.1
XP_030103902.1
XP_036014747.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168535.1 → NP_001162007.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001162007.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AC147044, AK032600, AK038926, BE648840, CX242881
    Consensus CDS
    CCDS49514.1
    UniProtKB/TrEMBL
    G3UW39
    Related
    ENSMUSP00000153357.2, ENSMUST00000225839.2
    Conserved Domains (2) summary
    cd01286
    Location:320 → 455
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:83 → 152
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

  2. NM_001168536.1 → NP_001162008.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001162008.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a different 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK009280, AK039148, CX242881
    Consensus CDS
    CCDS49515.1
    UniProtKB/Swiss-Prot
    Q8BMD5
    Related
    ENSMUSP00000128064.2, ENSMUST00000171683.3
    Conserved Domains (2) summary
    cd01286
    Location:320 → 455
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:83 → 152
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

  3. NM_001168537.1 → NP_001162009.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001162009.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC147044, AK032600, AK038926, BE648840, CX242881
    Consensus CDS
    CCDS49513.1
    UniProtKB/Swiss-Prot
    Q8BMD5
    Related
    ENSMUSP00000022555.4, ENSMUST00000022555.11
    Conserved Domains (2) summary
    cd01286
    Location:320 → 455
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:83 → 152
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

  4. NM_001168538.1 → NP_001162010.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC147044, AK032813, AK039148, CX242881
    Consensus CDS
    CCDS88678.1
    UniProtKB/Swiss-Prot
    Q8BMD5
    Related
    ENSMUSP00000128022.3, ENSMUST00000167100.9
    Conserved Domains (2) summary
    cd01286
    Location:320 → 455
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:83 → 152
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

  5. NM_027986.3 → NP_082262.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_082262.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK032813, CO039661, CX242881
    Consensus CDS
    CCDS36940.1
    UniProtKB/Swiss-Prot
    Q8BMD5, Q8BYL2, Q8BYN1, Q8C014, Q922P4, Q99KL2, Q9D7F3
    Related
    ENSMUSP00000052233.8, ENSMUST00000056997.15
    Conserved Domains (2) summary
    cd01286
    Location:320 → 455
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:83 → 152
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

RNA

  1. NR_153387.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC147044, AK032813, AK039148, CX242881

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    59796837..59835433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245204.4 → XP_011243506.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd01286
    Location:320 → 455
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:83 → 152
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

  2. XM_030248042.2 → XP_030103902.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    cl00269
    Location:20 → 139
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

  3. XM_036158854.1 → XP_036014747.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    cl00269
    Location:20 → 139
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

RNA

  1. XR_004938452.1 RNA Sequence

  2. XR_004938455.1 RNA Sequence

  3. XR_004938454.1 RNA Sequence

  4. XR_004938451.1 RNA Sequence

  5. XR_004938450.1 RNA Sequence

  6. XR_004938448.1 RNA Sequence

  7. XR_004938449.1 RNA Sequence

  8. XR_004938456.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMD5.1 GenPept UniProtKB/Swiss-Prot:Q8BMD5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous