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Chit1 chitinase 1 [ Mus musculus (house mouse) ]

Gene ID: 71884, updated on 21-Apr-2024

Summary

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Official Symbol
Chit1provided by MGI
Official Full Name
chitinase 1provided by MGI
Primary source
MGI:MGI:1919134
See related
Ensembl:ENSMUSG00000026450 AllianceGenome:MGI:1919134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2300002L19Rik
Summary
Predicted to enable chitin binding activity and endochitinase activity. Predicted to be involved in chitin catabolic process. Predicted to act upstream of or within polysaccharide catabolic process. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Orthologous to human CHIT1 (chitinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 20.5), testis adult (RPKM 3.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 58.12 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134038980..134079279)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134111242..134151541)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3302 Neighboring gene STARR-positive B cell enhancer mm9_chr1:135990501-135990802 Neighboring gene STARR-seq mESC enhancer starr_02317 Neighboring gene predicted gene, 32039 Neighboring gene Btg2R9 erythroid cis-regulatory module Neighboring gene STARR-positive B cell enhancer ABC_E7752 Neighboring gene predicted gene 8618 Neighboring gene predicted gene, 46158 Neighboring gene STARR-seq mESC enhancer starr_02318 Neighboring gene chitinase 3 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation and Role of Chitotriosidase during Lung Infection with Klebsiella pneumoniae. Sharma L, et al. J Immunol, 2018 Jul 15. PMID 29891554, Free PMC Article
  2. Molecular cloning and functional characterization of mouse chitotriosidase. Zheng T, et al. Gene, 2005 Aug 29. PMID 16005164
  3. Marked differences in tissue-specific expression of chitinases in mouse and man. Boot RG, et al. J Histochem Cytochem, 2005 Oct. PMID 15923370
  4. Comparative functional analysis between human and mouse chitotriosidase: Substitution at amino acid 218 modulates the chitinolytic and transglycosylation activity. Kimura M, et al. Int J Biol Macromol, 2020 Dec 1. PMID 32853624
  5. Chitinase inhibition promotes atherosclerosis in hyperlipidemic mice. Kitamoto S, et al. Am J Pathol, 2013 Jul. PMID 23685110, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparative functional analysis between human and mouse chitotriosidase: Substitution at amino acid 218 modulates the chitinolytic and transglycosylation activity.
    Title: Comparative functional analysis between human and mouse chitotriosidase: Substitution at amino acid 218 modulates the chitinolytic and transglycosylation activity.
  2. these data show a detrimental role of chit1 in Klebsiella pneumoniae lung infections
    Title: Regulation and Role of Chitotriosidase during Lung Infection with Klebsiella pneumoniae.
  3. No significant differences were observed between experimental autoimmune encephalitis and control groups for CHIT-1 expression.
    Title: Breast regression protein-39 is not required for experimental autoimmune encephalomyelitis induction.
  4. CHIT1 exerts protective effects against atherosclerosis by suppressing inflammatory responses and polarizing macrophages toward an M2 phenotype, and promoting lipid uptake and cholesterol efflux in macrophages.
    Title: Chitinase inhibition promotes atherosclerosis in hyperlipidemic mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables endochitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within polysaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chitotriosidase-1
Names
chitinase 1 (chitotriosidase)
NP_001271453.1
NP_001271454.1
NP_082255.1
XP_006529942.1
XP_006529943.1
XP_006529944.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284524.1 → NP_001271453.1  chitotriosidase-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001271453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate exon in the 3' coding region which causes a frameshift, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK009012, AV087814
    Consensus CDS
    CCDS69943.1
    UniProtKB/Swiss-Prot
    Q9D7Q1
    Related
    ENSMUSP00000124331.2, ENSMUST00000160060.8
    Conserved Domains (1) summary
    cd02872
    Location:24 → 345
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

  2. NM_001284525.1 → NP_001271454.1  chitotriosidase-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001271454.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AK009012, AY536287, BC138765
    Consensus CDS
    CCDS15304.1
    UniProtKB/Swiss-Prot
    Q6QJD2, Q9D7Q1
    UniProtKB/TrEMBL
    B2RS82
    Conserved Domains (2) summary
    cd02872
    Location:24 → 383
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    pfam01607
    Location:418 → 464
    CBM_14; Chitin binding Peritrophin-A domain

  3. NM_027979.2 → NP_082255.1  chitotriosidase-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_082255.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK009012, AY458654, AY536287
    Consensus CDS
    CCDS15304.1
    UniProtKB/Swiss-Prot
    Q6QJD2, Q9D7Q1
    UniProtKB/TrEMBL
    B2RS82
    Related
    ENSMUSP00000123979.2, ENSMUST00000159963.8
    Conserved Domains (2) summary
    cd02872
    Location:24 → 383
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    pfam01607
    Location:418 → 464
    CBM_14; Chitin binding Peritrophin-A domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134038980..134079279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529879.3 → XP_006529942.1  chitotriosidase-1 isoform X1

    See identical proteins and their annotated locations for XP_006529942.1

    UniProtKB/Swiss-Prot
    Q6QJD2, Q9D7Q1
    UniProtKB/TrEMBL
    B2RS82
    Conserved Domains (2) summary
    cd02872
    Location:24 → 383
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    pfam01607
    Location:418 → 464
    CBM_14; Chitin binding Peritrophin-A domain

  2. XM_006529880.2 → XP_006529943.1  chitotriosidase-1 isoform X1

    See identical proteins and their annotated locations for XP_006529943.1

    UniProtKB/Swiss-Prot
    Q6QJD2, Q9D7Q1
    UniProtKB/TrEMBL
    B2RS82
    Conserved Domains (2) summary
    cd02872
    Location:24 → 383
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    pfam01607
    Location:418 → 464
    CBM_14; Chitin binding Peritrophin-A domain

  3. XM_006529881.3 → XP_006529944.1  chitotriosidase-1 isoform X2

    See identical proteins and their annotated locations for XP_006529944.1

    UniProtKB/Swiss-Prot
    Q9D7Q1
    Conserved Domains (1) summary
    cd02872
    Location:24 → 345
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7Q1.2 GenPept UniProtKB/Swiss-Prot:Q9D7Q1

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