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Fbxo30 F-box protein 30 [ Mus musculus (house mouse) ]

Gene ID: 71865, updated on 4-May-2024

Summary

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Official Symbol
Fbxo30provided by MGI
Official Full Name
F-box protein 30provided by MGI
Primary source
MGI:MGI:1919115
See related
Ensembl:ENSMUSG00000047648 AllianceGenome:MGI:1919115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MUSA1; 1700026A16Rik
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human FBXO30 (F-box protein 30). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 16.8), liver E14 (RPKM 9.9) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A1; 10 3.66 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (11157009..11181494)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (11281330..11305750)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930567K20 gene Neighboring gene glutamate receptor, metabotropic 1 Neighboring gene STARR-seq mESC enhancer starr_25749 Neighboring gene STARR-positive B cell enhancer ABC_E9129 Neighboring gene SNF2 histone linker PHD RING helicase Neighboring gene STARR-seq mESC enhancer starr_25751 Neighboring gene STARR-seq mESC enhancer starr_25754 Neighboring gene STARR-seq mESC enhancer starr_25755 Neighboring gene STARR-seq mESC enhancer starr_25756 Neighboring gene STARR-seq mESC enhancer starr_25757 Neighboring gene predicted gene, 25979 Neighboring gene ribosomal protein L17, pseudogene 11 Neighboring gene epilepsy, progressive myoclonic epilepsy, type 2 gene alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5. Liu Y, et al. Cell Rep, 2016 May 3. PMID 27117404, Free PMC Article
  2. Fbxo30 regulates chromosome segregation of oocyte meiosis. Jin Y, et al. Cell Mol Life Sci, 2019 Jun. PMID 30980108
  3. BMP signaling controls muscle mass. Sartori R, et al. Nat Genet, 2013 Nov. PMID 24076600
  4. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
  5. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
F-box only protein 30
Names
muscle ubiquitin ligase of SCF complex in atrophy-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168297.1 → NP_001161769.1  F-box only protein 30

    See identical proteins and their annotated locations for NP_001161769.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC167234, AK006369, AK047174, AK083479, AK135274
    Consensus CDS
    CCDS23697.1
    UniProtKB/Swiss-Prot
    Q3UXU4, Q8BJL1, Q8CI21, Q9D9X5
    Related
    ENSMUSP00000068230.5, ENSMUST00000070300.5
    Conserved Domains (2) summary
    pfam15965
    Location:8 → 100
    zf-TRAF_2; TRAF-like zinc-finger
    pfam15966
    Location:614 → 722
    F-box_4

  2. NM_027968.3 → NP_082244.2  F-box only protein 30

    See identical proteins and their annotated locations for NP_082244.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC167234, AK047174, AK083479, AK135274
    Consensus CDS
    CCDS23697.1
    UniProtKB/Swiss-Prot
    Q3UXU4, Q8BJL1, Q8CI21, Q9D9X5
    Related
    ENSMUSP00000117687.2, ENSMUST00000129456.8
    Conserved Domains (2) summary
    pfam15965
    Location:8 → 100
    zf-TRAF_2; TRAF-like zinc-finger
    pfam15966
    Location:614 → 722
    F-box_4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    11157009..11181494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156027.1 → XP_036011920.1  F-box only protein 30 isoform X2

    Conserved Domains (2) summary
    pfam15965
    Location:8 → 100
    zf-TRAF_2; TRAF-like zinc-finger
    cl02535
    Location:612 → 679
    F-box-like

  2. XM_006512859.5 → XP_006512922.1  F-box only protein 30 isoform X1

    See identical proteins and their annotated locations for XP_006512922.1

    UniProtKB/Swiss-Prot
    Q3UXU4, Q8BJL1, Q8CI21, Q9D9X5
    Conserved Domains (2) summary
    pfam15965
    Location:8 → 100
    zf-TRAF_2; TRAF-like zinc-finger
    pfam15966
    Location:614 → 722
    F-box_4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJL1.2 GenPept UniProtKB/Swiss-Prot:Q8BJL1

Gene LinkOut

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