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Osgin1 oxidative stress induced growth inhibitor 1 [ Mus musculus (house mouse) ]

Gene ID: 71839, updated on 5-Mar-2024

Summary

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Official Symbol
Osgin1provided by MGI
Official Full Name
oxidative stress induced growth inhibitor 1provided by MGI
Primary source
MGI:MGI:1919089
See related
Ensembl:ENSMUSG00000074063 AllianceGenome:MGI:1919089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Okl38; 1700012B18Rik
Summary
Predicted to enable growth factor activity. Predicted to be involved in several processes, including negative regulation of cell growth; regulation of apoptotic process; and regulation of cell migration. Predicted to act upstream of or within cell differentiation and regulation of growth. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human OSGIN1 (oxidative stress induced growth inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 153.0), testis adult (RPKM 130.4) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 67.71 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120160874..120172996)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119425882..119446257)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45723 Neighboring gene STARR-positive B cell enhancer ABC_E3809 Neighboring gene malonyl-CoA decarboxylase Neighboring gene predicted gene, 32006 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:121947490-121947599 Neighboring gene STARR-positive B cell enhancer ABC_E2879 Neighboring gene STARR-positive B cell enhancer ABC_E10526 Neighboring gene N-terminal EF-hand calcium binding protein 2 Neighboring gene predicted gene, 53462 Neighboring gene solute carrier family 38, member 8 Neighboring gene STARR-seq mESC enhancer starr_22850

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Sah RK, et al. Int J Mol Sci, 2020 Nov 3. PMID 33153107, Free PMC Article
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
oxidative stress-induced growth inhibitor 1
Names
pregnancy-induced growth inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027950.2 → NP_082226.1  oxidative stress-induced growth inhibitor 1

    See identical proteins and their annotated locations for NP_082226.1

    Status: VALIDATED

    Source sequence(s)
    AC166781
    Consensus CDS
    CCDS22704.1
    UniProtKB/Swiss-Prot
    Q8VC10
    UniProtKB/TrEMBL
    Q9CVY9
    Related
    ENSMUSP00000114467.2, ENSMUST00000152420.8
    Conserved Domains (2) summary
    TIGR04018
    Location:239 → 472
    Bthiol_YpdA; putative bacillithiol system oxidoreductase, YpdA family
    cl21454
    Location:168 → 303
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. NR_157155.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166781
    Related
    ENSMUST00000098365.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    120160874..120172996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531377.4 → XP_006531440.1  oxidative stress-induced growth inhibitor 1 isoform X1

    See identical proteins and their annotated locations for XP_006531440.1

    UniProtKB/Swiss-Prot
    Q8VC10
    UniProtKB/TrEMBL
    Q9CVY9
    Conserved Domains (2) summary
    TIGR04018
    Location:239 → 472
    Bthiol_YpdA; putative bacillithiol system oxidoreductase, YpdA family
    cl21454
    Location:168 → 303
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_006531381.5 → XP_006531444.1  oxidative stress-induced growth inhibitor 1 isoform X1

    See identical proteins and their annotated locations for XP_006531444.1

    UniProtKB/Swiss-Prot
    Q8VC10
    UniProtKB/TrEMBL
    Q9CVY9
    Conserved Domains (2) summary
    TIGR04018
    Location:239 → 472
    Bthiol_YpdA; putative bacillithiol system oxidoreductase, YpdA family
    cl21454
    Location:168 → 303
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC10.1 GenPept UniProtKB/Swiss-Prot:Q8VC10

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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