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Ranbp3 RAN binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 71810, updated on 11-Apr-2024

Summary

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Official Symbol
Ranbp3provided by MGI
Official Full Name
RAN binding protein 3provided by MGI
Primary source
MGI:MGI:1919060
See related
Ensembl:ENSMUSG00000002372 AllianceGenome:MGI:1919060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610024N24Rik
Summary
Predicted to enable R-SMAD binding activity and small GTPase binding activity. Predicted to contribute to GTPase activator activity. Predicted to be involved in protein export from nucleus. Predicted to act upstream of or within protein transport. Predicted to be located in nucleoplasm. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. Is expressed in central nervous system and sensory organ. Orthologous to human RANBP3 (RAN binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 37.4), ovary adult (RPKM 34.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ranbp3 in Genome Data Viewer
Location:
17 29.45 cM; 17 D
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56980225..57018769)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56673225..56711769)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene lon peptidase 1, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E3210 Neighboring gene cation channel sperm associated auxiliary subunit delta Neighboring gene predicted gene, 33461 Neighboring gene STARR-seq mESC enhancer starr_42897 Neighboring gene STARR-seq mESC enhancer starr_42898 Neighboring gene STARR-positive B cell enhancer ABC_E962 Neighboring gene calcyphosine, pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit A11 Neighboring gene vimentin-type intermediate filament associated coiled-coil protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3. Dai F, et al. EMBO Rep, 2011 Oct 28. PMID 21960005, Free PMC Article
  2. PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors. Budzinska MI, et al. J Cell Sci, 2020 Mar 30. PMID 32079660, Free PMC Article
  3. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein phosphatase PPM1A regulates the nuclear export of Smad2/3 through targeting nuclear exporter RanBP3.
    Title: PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ran-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252466.1 → NP_001239395.1  ran-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001239395.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BB726920, BC066005, CA318306, CT010491
    Consensus CDS
    CCDS89127.1
    UniProtKB/TrEMBL
    A0A3B2WCL5
    Related
    ENSMUSP00000156588.2, ENSMUST00000233319.2
    Conserved Domains (1) summary
    cd13180
    Location:384 → 499
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  2. NM_001252467.1 → NP_001239396.1  ran-binding protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001239396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    BB726920, BC066005, CN717165, CT010491
    Conserved Domains (1) summary
    cd13180
    Location:264 → 379
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  3. NM_027933.3 → NP_082209.1  ran-binding protein 3 isoform 2

    See identical proteins and their annotated locations for NP_082209.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK133949, BB726920, CT010491
    Consensus CDS
    CCDS28911.1
    UniProtKB/Swiss-Prot
    A6H6I9, Q3TIS4, Q3U2G4, Q3UYG7, Q9CT10
    Related
    ENSMUSP00000002445.9, ENSMUST00000002445.10
    Conserved Domains (1) summary
    cd13180
    Location:317 → 432
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

RNA

  1. NR_045519.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal exon and includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BB726920, BC066005, BM950080, CT010491

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56980225..57018769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524945.4 → XP_006525008.1  ran-binding protein 3 isoform X6

    Conserved Domains (1) summary
    cd13180
    Location:353 → 468
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  2. XM_030250054.1 → XP_030105914.1  ran-binding protein 3 isoform X8

    Conserved Domains (1) summary
    cd13180
    Location:331 → 446
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  3. XM_030250055.1 → XP_030105915.1  ran-binding protein 3 isoform X10

    Conserved Domains (1) summary
    cd13180
    Location:286 → 401
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  4. XM_006524944.2 → XP_006525007.1  ran-binding protein 3 isoform X1

    Conserved Domains (1) summary
    cd13180
    Location:437 → 552
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  5. XM_017317645.3 → XP_017173134.1  ran-binding protein 3 isoform X3

    Conserved Domains (1) summary
    cd13180
    Location:406 → 521
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  6. XM_017317646.2 → XP_017173135.1  ran-binding protein 3 isoform X4

    Conserved Domains (1) summary
    cd13180
    Location:384 → 499
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  7. XM_017317647.1 → XP_017173136.1  ran-binding protein 3 isoform X5

    Conserved Domains (1) summary
    cd13180
    Location:370 → 485
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  8. XM_017317648.1 → XP_017173137.1  ran-binding protein 3 isoform X7

    Conserved Domains (2) summary
    cd13180
    Location:339 → 454
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
    pfam15392
    Location:4 → 204
    Joubert; Joubert syndrome-associated

  9. XM_017317649.1 → XP_017173138.1  ran-binding protein 3 isoform X9

    Conserved Domains (1) summary
    cd13180
    Location:317 → 432
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  10. XM_011246620.1 → XP_011244922.1  ran-binding protein 3 isoform X2

    Conserved Domains (1) summary
    cd13180
    Location:410 → 525
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  11. XM_030250056.1 → XP_030105916.1  ran-binding protein 3 isoform X11

    Conserved Domains (1) summary
    cd13180
    Location:192 → 307
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

RNA

  1. XR_004939581.1 RNA Sequence

  2. XR_001782113.3 RNA Sequence

  3. XR_004939580.1 RNA Sequence

  4. XR_003952184.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CT10.2 GenPept UniProtKB/Swiss-Prot:Q9CT10

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