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Tars2 threonyl-tRNA synthetase 2, mitochondrial (putative) [ Mus musculus (house mouse) ]

Gene ID: 71807, updated on 11-Apr-2024

Summary

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Official Symbol
Tars2provided by MGI
Official Full Name
threonyl-tRNA synthetase 2, mitochondrial (putative)provided by MGI
Primary source
MGI:MGI:1919057
See related
Ensembl:ENSMUSG00000028107 AllianceGenome:MGI:1919057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
thrRS; Tarsl1; 2610024N01Rik
Summary
Predicted to enable aminoacyl-tRNA editing activity; protein homodimerization activity; and threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21. Orthologous to human TARS2 (threonyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.8), large intestine adult (RPKM 6.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tars2 in Genome Data Viewer
Location:
3 F2.1; 3 40.93 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95647286..95663677, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95739974..95756365, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene myeloid cell leukemia sequence 1 Neighboring gene ADAMTS-like 4 Neighboring gene STARR-seq mESC enhancer starr_08394 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95511513-95511622 Neighboring gene microRNA 7014 Neighboring gene extracellular matrix protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E2087 Neighboring gene regulation of nuclear pre-mRNA domain containing 2 Neighboring gene predicted gene, 26361 Neighboring gene lactate dehydrogenase A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockdown of mitochondrial threonyl-tRNA synthetase 2 inhibits lung adenocarcinoma cell proliferation and induces apoptosis. Tian H, et al. Bioengineered, 2022 Mar. PMID 35184682, Free PMC Article
  2. Molecular dynamics investigation into substrate binding and identity of the catalytic base in the mechanism of Threonyl-tRNA synthetase. Bushnell EA, et al. J Phys Chem B, 2012 May 3. PMID 22482363
  3. Threonyl-tRNA synthetase. Freist W, et al. Biol Chem Hoppe Seyler, 1995 Apr. PMID 7626230
  4. Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events. Wolf YI, et al. Genome Res, 1999 Aug. PMID 10447505
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of mitochondrial threonyl-tRNA synthetase 2 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.
    Title: Knockdown of mitochondrial threonyl-tRNA synthetase 2 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity ISO
Inferred from Sequence Orthology
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables threonine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables threonine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in threonyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
threonine--tRNA ligase, mitochondrial
Names
threonyl-tRNA synthetase, mitochondrial
threonyl-tRNA synthetase-like 1
NP_001157089.1
NP_001157090.1
NP_001157091.1
NP_001343894.1
NP_001343895.1
NP_001343896.1
NP_082207.2
XP_011238538.1
XP_030108688.1
XP_030108689.1
XP_036019229.1
XP_036019230.1
XP_036019231.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163617.1 → NP_001157089.1  threonine--tRNA ligase, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001157089.1

    Status: VALIDATED

    Source sequence(s)
    AC093317, AK142685, BG277177, CO042173
    Consensus CDS
    CCDS50996.1
    UniProtKB/TrEMBL
    Q922A3
    Related
    ENSMUSP00000073946.7, ENSMUST00000074339.13
    Conserved Domains (5) summary
    cd01667
    Location:66 → 127
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:27 → 689
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:234 → 281
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:305 → 592
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:592 → 683
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

  2. NM_001163618.1 → NP_001157090.1  threonine--tRNA ligase, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093317, AK142685, BG087111, CO042173
    Consensus CDS
    CCDS50994.1
    UniProtKB/TrEMBL
    E9Q7H6
    Related
    ENSMUSP00000130269.2, ENSMUST00000163530.8
    Conserved Domains (5) summary
    cd01667
    Location:66 → 127
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:27 → 634
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:153 → 200
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:224 → 537
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:537 → 628
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

  3. NM_001163619.1 → NP_001157091.1  threonine--tRNA ligase, mitochondrial isoform 4

    See identical proteins and their annotated locations for NP_001157091.1

    Status: VALIDATED

    Source sequence(s)
    AC093317, AK164589
    Consensus CDS
    CCDS50995.1
    UniProtKB/TrEMBL
    Q3TP97
    Related
    ENSMUSP00000096456.5, ENSMUST00000098857.9
    Conserved Domains (3) summary
    cd01667
    Location:66 → 127
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    smart00863
    Location:234 → 281
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cl00268
    Location:305 → 417
    class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

  4. NM_001356965.1 → NP_001343894.1  threonine--tRNA ligase, mitochondrial isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC093317, CO042173, MG954306
    Conserved Domains (1) summary
    PLN02908
    Location:3 → 476
    PLN02908; threonyl-tRNA synthetase

  5. NM_001356966.1 → NP_001343895.1  threonine--tRNA ligase, mitochondrial isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC093317, CO042173, MG954306
    Conserved Domains (1) summary
    PLN02908
    Location:3 → 476
    PLN02908; threonyl-tRNA synthetase

  6. NM_001356967.1 → NP_001343896.1  threonine--tRNA ligase, mitochondrial isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC093317, CO042173, MG954306
    Conserved Domains (1) summary
    PLN02908
    Location:3 → 476
    PLN02908; threonyl-tRNA synthetase

  7. NM_027931.3 → NP_082207.2  threonine--tRNA ligase, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_082207.2

    Status: VALIDATED

    Source sequence(s)
    AC093317, AK142685, CO042173
    Consensus CDS
    CCDS38548.1
    UniProtKB/Swiss-Prot
    B2RW19, Q3UQ84, Q9D0D6
    Related
    ENSMUSP00000029752.9, ENSMUST00000029752.15
    Conserved Domains (1) summary
    PLN02908
    Location:27 → 715
    PLN02908; threonyl-tRNA synthetase

RNA

  1. NR_151588.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093317, CO042173, MG954306
    Related
    ENSMUST00000199464.5

  2. NR_151589.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093317, AK164825, CO042173, MG954306
    Related
    ENSMUST00000196077.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95647286..95663677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252828.1 → XP_030108688.1  threonine--tRNA ligase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    B2RW19, Q3UQ84, Q9D0D6
    Conserved Domains (1) summary
    PLN02908
    Location:27 → 715
    PLN02908; threonyl-tRNA synthetase

  2. XM_011240236.2 → XP_011238538.1  threonine--tRNA ligase, mitochondrial isoform X2

    Conserved Domains (1) summary
    PLN02908
    Location:27 → 666
    PLN02908; threonyl-tRNA synthetase

  3. XM_036163336.1 → XP_036019229.1  threonine--tRNA ligase, mitochondrial isoform X3

    Conserved Domains (1) summary
    PLN02908
    Location:27 → 585
    PLN02908; threonyl-tRNA synthetase

  4. XM_036163337.1 → XP_036019230.1  threonine--tRNA ligase, mitochondrial isoform X4

    Conserved Domains (1) summary
    PLN02908
    Location:3 → 476
    PLN02908; threonyl-tRNA synthetase

  5. XM_036163338.1 → XP_036019231.1  threonine--tRNA ligase, mitochondrial isoform X4

    Conserved Domains (1) summary
    PLN02908
    Location:3 → 476
    PLN02908; threonyl-tRNA synthetase

  6. XM_030252829.1 → XP_030108689.1  threonine--tRNA ligase, mitochondrial isoform X4

    Conserved Domains (1) summary
    PLN02908
    Location:3 → 476
    PLN02908; threonyl-tRNA synthetase

RNA

  1. XR_004941399.1 RNA Sequence

  2. XR_004941400.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UQ84.1 GenPept UniProtKB/Swiss-Prot:Q3UQ84

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