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Nup93 nucleoporin 93 [ Mus musculus (house mouse) ]

Gene ID: 71805, updated on 3-Apr-2024

Summary

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Official Symbol
Nup93provided by MGI
Official Full Name
nucleoporin 93provided by MGI
Primary source
MGI:MGI:1919055
See related
Ensembl:ENSMUSG00000032939 AllianceGenome:MGI:1919055
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410008G02Rik
Summary
Predicted to be a structural constituent of nuclear pore. Involved in SMAD protein signal transduction and positive regulation of SMAD protein signal transduction. Located in centrosome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 12. Orthologous to human NUP93 (nucleoporin 93). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 18.5), limb E14.5 (RPKM 14.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C5; 8 46.4 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94941203..95043858)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94214564..94328100)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:96707225-96707334 Neighboring gene uncharacterized LOC118567560 Neighboring gene metallothionein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3793 Neighboring gene ribosomal protein L10, pseudogene 5 Neighboring gene microRNA 138-2 Neighboring gene solute carrier family 12, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E8256 Neighboring gene STARR-positive B cell enhancer ABC_E3794

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses. Monwan W, et al. Biochem Biophys Res Commun, 2020 Jan 22. PMID 31733835
  2. The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice. Beckers A, et al. Sci Rep, 2018 Oct 2. PMID 30279523, Free PMC Article
  3. Functional interaction of CREB binding protein (CBP) with nuclear transport proteins and modulation by HDAC inhibitors. Ryan CM, et al. Cell Cycle, 2006 Sep. PMID 16969114
  4. Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome. Braun DA, et al. Nat Genet, 2016 Apr. PMID 26878725, Free PMC Article
  5. TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination. Li W, et al. Cell Commun Signal, 2019 Dec 10. PMID 31823782, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nup93 regulates antiviral innate immunity by enhancing TBK1 activity and IRF3 nuclear translocation.
    Title: Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear pore complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear periphery ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear pore complex protein Nup93
Names
93 kDa nucleoporin
CBP-interacting protein 4
nucleoporin Nup93

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357266.2 → NP_001344195.1  nuclear pore complex protein Nup93 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733
    Consensus CDS
    CCDS22540.1
    UniProtKB/Swiss-Prot
    Q3TED9, Q8BIK7, Q8BJ71, Q8K1R4, Q8R592
    UniProtKB/TrEMBL
    Q3TFC8
    Related
    ENSMUSP00000078878.7, ENSMUST00000079961.14
    Conserved Domains (1) summary
    pfam04097
    Location:220 → 802
    Nic96; Nup93/Nic96

  2. NM_001357267.2 → NP_001344196.1  nuclear pore complex protein Nup93 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733
    UniProtKB/TrEMBL
    Q3TFC8
    Conserved Domains (1) summary
    pfam04097
    Location:97 → 679
    Nic96; Nup93/Nic96

  3. NM_001357268.2 → NP_001344197.1  nuclear pore complex protein Nup93 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733
    Consensus CDS
    CCDS90438.1
    UniProtKB/TrEMBL
    A0A1D5RLQ0, Q3TFC8
    Related
    ENSMUSP00000148458.2, ENSMUST00000211822.2
    Conserved Domains (1) summary
    pfam04097
    Location:97 → 679
    Nic96; Nup93/Nic96

  4. NM_001424438.1 → NP_001411367.1  nuclear pore complex protein Nup93 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733

  5. NM_001424439.1 → NP_001411368.1  nuclear pore complex protein Nup93 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733

  6. NM_001424440.1 → NP_001411369.1  nuclear pore complex protein Nup93 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733

  7. NM_001424441.1 → NP_001411370.1  nuclear pore complex protein Nup93 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733

  8. NM_001424442.1 → NP_001411371.1  nuclear pore complex protein Nup93 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733

  9. NM_001424443.1 → NP_001411372.1  nuclear pore complex protein Nup93 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733

  10. NM_001424444.1 → NP_001411373.1  nuclear pore complex protein Nup93 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733

  11. NM_001424445.1 → NP_001411374.1  nuclear pore complex protein Nup93 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733

  12. NM_001424446.1 → NP_001411375.1  nuclear pore complex protein Nup93 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733

  13. NM_001424447.1 → NP_001411376.1  nuclear pore complex protein Nup93 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733

  14. NM_172410.4 → NP_765998.1  nuclear pore complex protein Nup93 isoform 1

    See identical proteins and their annotated locations for NP_765998.1

    Status: VALIDATED

    Source sequence(s)
    AC128663, AC131733
    Consensus CDS
    CCDS22540.1
    UniProtKB/Swiss-Prot
    Q3TED9, Q8BIK7, Q8BJ71, Q8K1R4, Q8R592
    UniProtKB/TrEMBL
    Q3TFC8
    Related
    ENSMUSP00000148700.2, ENSMUST00000212824.2
    Conserved Domains (1) summary
    pfam04097
    Location:220 → 802
    Nic96; Nup93/Nic96

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    94941203..95043858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJ71.1 GenPept UniProtKB/Swiss-Prot:Q8BJ71

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