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Cpa4 carboxypeptidase A4 [ Mus musculus (house mouse) ]

Gene ID: 71791, updated on 21-Apr-2024

Summary

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Official Symbol
Cpa4provided by MGI
Official Full Name
carboxypeptidase A4provided by MGI
Primary source
MGI:MGI:1919041
See related
Ensembl:ENSMUSG00000039070 AllianceGenome:MGI:1919041
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110019K20Rik
Summary
This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases that could be involved in the histone hyperacetylation pathway. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]
Expression
Biased expression in stomach adult (RPKM 3.3), limb E14.5 (RPKM 1.8) and 6 other tissues See more
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Genomic context

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Location:
6 A3.3; 6 12.52 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30568368..30592417)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30568369..30592418)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15468 Neighboring gene serine-rich single-pass membrane protein 1 Neighboring gene predicted gene, 53278 Neighboring gene carboxypeptidase A2, pancreatic Neighboring gene predicted gene, 31453 Neighboring gene carboxypeptidase A5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing. Tanco S, et al. J Biol Chem, 2010 Jun 11. PMID 20385563, Free PMC Article
  2. Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling. Gao W, et al. Biosci Rep, 2020 May 29. PMID 32347291, Free PMC Article
  3. Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Hald J, et al. Dev Biol, 2003 Aug 15. PMID 12921743
  4. Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Inagawa M, et al. Mech Dev, 2013 Nov-Dec. PMID 23892084
  5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling.
    Title: Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling.
  2. CPA4 functions in neuropeptide processing and regulation in the extracellular environment
    Title: Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hormone catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
carboxypeptidase A4
NP_082202.1
XP_017177239.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027926.3 → NP_082202.1  carboxypeptidase A4 preproprotein

    See identical proteins and their annotated locations for NP_082202.1

    Status: REVIEWED

    Source sequence(s)
    AC155656, AK003823, AK030705
    Consensus CDS
    CCDS19975.1
    UniProtKB/Swiss-Prot
    Q6P8K8, Q8BMK6, Q9CTE6
    Related
    ENSMUSP00000048558.6, ENSMUST00000049251.6
    Conserved Domains (2) summary
    pfam02244
    Location:28 → 100
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:117 → 418
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    30568368..30592417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321750.1 → XP_017177239.1  carboxypeptidase A4 isoform X1

    Conserved Domains (2) summary
    cd03870
    Location:166 → 467
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:81 → 150
    Propep_M14; Carboxypeptidase activation peptide
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P8K8.2 GenPept UniProtKB/Swiss-Prot:Q6P8K8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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