U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TPT1 tumor protein, translationally-controlled 1 [ Homo sapiens (human) ]

Gene ID: 7178, updated on 5-May-2024

Summary

Go to the top of the page Help
Official Symbol
TPT1provided by HGNC
Official Full Name
tumor protein, translationally-controlled 1provided by HGNC
Primary source
HGNC:HGNC:12022
See related
Ensembl:ENSG00000133112 MIM:600763; AllianceGenome:HGNC:12022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRF; p02; p23; TCTP
Summary
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in ovary (RPKM 496.6), thyroid (RPKM 416.5) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
13q14.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (45333471..45341183, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (44553718..44561430, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (45907606..45915318, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene general transcription factor IIF subunit 2 Neighboring gene uncharacterized LOC124903168 Neighboring gene uncharacterized LOC105370190 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr13:45883380-45884072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:45904287-45904787 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:45914388-45915177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5315 Neighboring gene uncharacterized LOC124903169 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:45916757-45917544 Neighboring gene small nucleolar RNA, H/ACA box 31B Neighboring gene small nucleolar RNA, H/ACA box 31 Neighboring gene TPT1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:45941608-45942114 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:45944664-45945164 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:45945165-45945665 Neighboring gene Sharpr-MPRA regulatory region 12652 Neighboring gene reticulocalbin 1 pseudogene 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas. Morais de Castro E, et al. ASN Neuro, 2023 Jan-Dec. PMID 36714975, Free PMC Article
  2. Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells. Hangai S, et al. Nat Immunol, 2021 Aug. PMID 34239121
  3. The mRNA of TCTP functions as a sponge to maintain homeostasis of TCTP protein levels in hepatocellular carcinoma. Liu W, et al. Cell Death Dis, 2020 Nov 12. PMID 33184257, Free PMC Article
  4. TCTP participates in hepatic metabolism by regulating gene expression involved in insulin resistance. Dong K, et al. Gene, 2021 Feb 5. PMID 33122078
  5. Conformational Ensemble and Biological Role of the TCTP Intrinsically Disordered Region: Influence of Calcium and Phosphorylation. Malard F, et al. J Mol Biol, 2018 May 25. PMID 29719201

See all (187) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elevated translationally controlled tumour protein promotes oral cancer progression and poor outcome.
    Title: Elevated translationally controlled tumour protein promotes oral cancer progression and poor outcome.
  2. METTL13 promotes nasopharyngeal carcinoma progression through regulating the ZEB1/TPT1 axis.
    Title: METTL13 promotes nasopharyngeal carcinoma progression through regulating the ZEB1/TPT1 axis.
  3. Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas.
    Title: Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas.
  4. Fortilin interacts with TGF-beta1 and prevents TGF-beta receptor activation.
    Title: Fortilin interacts with TGF-β1 and prevents TGF-β receptor activation.
  5. MiR-216a-5p inhibits tumorigenesis in Pancreatic Cancer by targeting TPT1/mTORC1 and is mediated by LINC01133.
    Title: MiR-216a-5p inhibits tumorigenesis in Pancreatic Cancer by targeting TPT1/mTORC1 and is mediated by LINC01133.
  6. Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis.
    Title: Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis.
  7. The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state.
    Title: The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state.
  8. Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells.
    Title: Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells.
  9. Guizhi Fuling pills inhibit the proliferation, migration and invasion of human cutaneous malignant melanoma cells by regulating the molecular axis of LncRNA TPT1-AS1 / miR-671-5p.
    Title: Guizhi Fuling pills inhibit the proliferation, migration and invasion of human cutaneous malignant melanoma cells by regulating the molecular axis of LncRNA TPT1-AS1 / miR-671-5p.
  10. The mRNA of TCTP functions as a sponge to maintain homeostasis of TCTP protein levels in hepatocellular carcinoma.
    Title: The mRNA of TCTP functions as a sponge to maintain homeostasis of TCTP protein levels in hepatocellular carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (106)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
Knockdown of tumor protein, translationally-controlled 1 (TPT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ27337

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transport IC
Inferred by Curator
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IC
Inferred by Curator
more info
 PubMed 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to virus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in multivesicular body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
translationally-controlled tumor protein
Names
fortilin
histamine-releasing factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286272.2 → NP_001273201.1  translationally-controlled tumor protein isoform 1

    See identical proteins and their annotated locations for NP_001273201.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL138963
    Consensus CDS
    CCDS73566.1
    UniProtKB/TrEMBL
    A0A0B4J2C3, Q5W0H4
    Related
    ENSP00000477781.1, ENST00000616577.4
    Conserved Domains (1) summary
    pfam00838
    Location:1 → 167
    TCTP; Translationally controlled tumor protein

  2. NM_001286273.2 → NP_001273202.1  translationally-controlled tumor protein isoform 3

    See identical proteins and their annotated locations for NP_001273202.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the coding region, compared to variant 1, including initiation of translation at a downstream in-frame start codon. The encoded isoform (3) has shorter N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AL138963, BC022436
    Consensus CDS
    CCDS66538.1
    Related
    ENSP00000368345.1, ENST00000379056.5
    Conserved Domains (1) summary
    pfam00838
    Location:1 → 133
    TCTP; Translationally controlled tumor protein

  3. NM_003295.4 → NP_003286.1  translationally-controlled tumor protein isoform 2

    See identical proteins and their annotated locations for NP_003286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter C-terminus than isoform 1.
    Source sequence(s)
    AL138963, BP215975, X16064
    Consensus CDS
    CCDS9397.1
    UniProtKB/Swiss-Prot
    B2R7E5, P13693, Q6YLS2, Q7Z4J4, Q8TBK7, Q96EE2, Q9UC70
    UniProtKB/TrEMBL
    A0A0P1J1R0, Q5W0H4
    Related
    ENSP00000431872.2, ENST00000530705.6
    Conserved Domains (1) summary
    pfam00838
    Location:1 → 167
    TCTP; Translationally controlled tumor protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    45333471..45341183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    44553718..44561430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13693.1 GenPept UniProtKB/Swiss-Prot:P13693

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous