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Ing3 inhibitor of growth family, member 3 [ Mus musculus (house mouse) ]

Gene ID: 71777, updated on 5-Mar-2024

Summary

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Official Symbol
Ing3provided by MGI
Official Full Name
inhibitor of growth family, member 3provided by MGI
Primary source
MGI:MGI:1919027
See related
Ensembl:ENSMUSG00000029670 AllianceGenome:MGI:1919027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P47ING3; 1300013A07Rik
Summary
Predicted to enable methylated histone binding activity. Predicted to be involved in histone acetylation; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization and regulation of growth. Predicted to be located in nucleoplasm. Predicted to be part of Piccolo NuA4 histone acetyltransferase complex and Swr1 complex. Is expressed in several structures, including central nervous system; early conceptus; foregut; genitourinary system; and sensory organ. Orthologous to human ING3 (inhibitor of growth family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 6.3), CNS E11.5 (RPKM 4.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A3.1; 6 8.81 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (21948002..21976037)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (21949571..21976038)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Shal-related family, member 2 Neighboring gene STARR-seq mESC enhancer starr_15300 Neighboring gene STARR-seq mESC enhancer starr_15301 Neighboring gene STARR-seq mESC enhancer starr_15302 Neighboring gene STARR-seq mESC enhancer starr_15303 Neighboring gene tetraspanin 12 Neighboring gene predicted gene, 30270 Neighboring gene STARR-positive B cell enhancer ABC_E676 Neighboring gene STARR-positive B cell enhancer ABC_E6418 Neighboring gene STARR-seq mESC enhancer starr_15304 Neighboring gene STARR-seq mESC enhancer starr_15305 Neighboring gene STARR-seq mESC enhancer starr_15306 Neighboring gene cadherin-like and PC-esterase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_15307 Neighboring gene STARR-seq mESC enhancer starr_15308 Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene predicted gene 42573

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of Ing3 Expression Results in Growth Retardation and Embryonic Death. Fink D, et al. Cancers (Basel), 2019 Dec 29. PMID 31905726, Free PMC Article
  2. ING3 is essential for asymmetric cell division during mouse oocyte maturation. Suzuki S, et al. PLoS One, 2013. PMID 24066152, Free PMC Article
  3. ING3 protein expression profiling in normal human tissues suggest its role in cellular growth and self-renewal. Nabbi A, et al. Eur J Cell Biol, 2015 May. PMID 25819753
  4. An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers. Fisher CL, et al. Nucleic Acids Res, 2017 Dec 1. PMID 28981838, Free PMC Article
  5. Hdac6 regulates Tip60-p400 function in stem cells. Chen PB, et al. Elife, 2013 Dec 3. PMID 24302573, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ING3 levels may serve as a surrogate for growth rate, and suggest possible roles for ING3 in growth and self renewal and related diseases such as cancer.
    Title: ING3 protein expression profiling in normal human tissues suggest its role in cellular growth and self-renewal.
  2. ING3 is essential for asymmetric cell division during mouse oocyte maturation
    Title: ING3 is essential for asymmetric cell division during mouse oocyte maturation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to histone H2A acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K16 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromatin organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Swr1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of piccolo histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inhibitor of growth protein 3
Names
p47 regulator protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311061.1 → NP_001297990.1  inhibitor of growth protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK080787, AK131993, AW457373, BB854183, BX527964, BY705188
    Consensus CDS
    CCDS80491.1
    UniProtKB/TrEMBL
    D3YUP8, Q3V3Y2
    Related
    ENSMUSP00000111047.2, ENSMUST00000115389.8
    Conserved Domains (3) summary
    COG5034
    Location:4 → 402
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15585
    Location:354 → 398
    PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
    pfam12998
    Location:3 → 102
    ING; Inhibitor of growth proteins N-terminal histone-binding

  2. NM_023626.4 → NP_076115.3  inhibitor of growth protein 3 isoform 1

    See identical proteins and their annotated locations for NP_076115.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC117213, AK080787
    Consensus CDS
    CCDS39434.1
    UniProtKB/Swiss-Prot
    Q8VEK6, Q99JS6, Q9ERB2
    UniProtKB/TrEMBL
    Q3V3Y2
    Related
    ENSMUSP00000031680.4, ENSMUST00000031680.10
    Conserved Domains (3) summary
    COG5034
    Location:4 → 413
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15585
    Location:365 → 409
    PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
    pfam12998
    Location:3 → 102
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    21948002..21976037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321747.3 → XP_017177236.1  inhibitor of growth protein 3 isoform X2

    UniProtKB/TrEMBL
    Q3V3Y2
    Conserved Domains (3) summary
    COG5034
    Location:235 → 378
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15585
    Location:330 → 374
    PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
    pfam12998
    Location:1 → 69
    ING; Inhibitor of growth proteins N-terminal histone-binding

  2. XM_036152310.1 → XP_036008203.1  inhibitor of growth protein 3 isoform X4

    UniProtKB/TrEMBL
    Q3V3Y2
    Conserved Domains (3) summary
    COG5034
    Location:224 → 367
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15585
    Location:319 → 363
    PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
    cd16858
    Location:1 → 63
    ING_ING3_Yng2p; Inhibitor of growth (ING) domain of inhibitor of growth protein 3 (ING3), Yng2p and similar proteins

  3. XM_006505166.5 → XP_006505229.1  inhibitor of growth protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006505229.1

    UniProtKB/TrEMBL
    Q3V3Y2
    Conserved Domains (3) summary
    COG5034
    Location:246 → 389
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15585
    Location:341 → 385
    PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
    pfam12998
    Location:3 → 80
    ING; Inhibitor of growth proteins N-terminal histone-binding

  4. XM_036152309.1 → XP_036008202.1  inhibitor of growth protein 3 isoform X3

    UniProtKB/TrEMBL
    Q3V3Y2
    Conserved Domains (3) summary
    COG5034
    Location:235 → 378
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15585
    Location:330 → 374
    PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
    cd16858
    Location:8 → 74
    ING_ING3_Yng2p; Inhibitor of growth (ING) domain of inhibitor of growth protein 3 (ING3), Yng2p and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEK6.2 GenPept UniProtKB/Swiss-Prot:Q8VEK6

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