U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tha1 threonine aldolase 1 [ Mus musculus (house mouse) ]

Gene ID: 71776, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
Tha1provided by MGI
Official Full Name
threonine aldolase 1provided by MGI
Primary source
MGI:MGI:1919026
See related
Ensembl:ENSMUSG00000017713 AllianceGenome:MGI:1919026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GLY1; 1300017K07Rik
Summary
Predicted to enable L-allo-threonine aldolase activity. Predicted to be involved in glycine biosynthetic process and threonine catabolic process. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; immune system; liver; musculature; and stomach. Orthologous to human THA1P (threonine aldolase 1, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 19.6), adrenal adult (RPKM 18.8) and 24 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 E2; 11 82.96 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117758775..117764352, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117867949..117873526, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm780 Neighboring gene baculoviral IAP repeat-containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E5307 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117733294-117733546 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117733656-117733839 Neighboring gene transmembrane protein 235 Neighboring gene predicted gene 11725 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117774097-117774206 Neighboring gene STARR-seq mESC enhancer starr_31285 Neighboring gene STARR-positive B cell enhancer ABC_E8474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117813554-117813821 Neighboring gene STARR-positive B cell enhancer ABC_E5308 Neighboring gene STARR-seq mESC enhancer starr_31288 Neighboring gene suppressor of cytokine signaling 3 Neighboring gene STARR-positive B cell enhancer ABC_E7103 Neighboring gene phosphatidylglycerophosphate synthase 1 Neighboring gene microRNA 6933

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogene. Edgar AJ. BMC Genomics, 2005 Mar 9. PMID 15757516, Free PMC Article
  2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mice, the western-clawed frog and the zebrafish have transcribed threonine aldolase/GLY1 genes, but the human homolog is a non-transcribed pseudogene
    Title: Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogene.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-allo-threonine aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in glycine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
threonine aldolase 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027919.4 → NP_082195.2  threonine aldolase 1

    See identical proteins and their annotated locations for NP_082195.2

    Status: VALIDATED

    Source sequence(s)
    AL591433
    Consensus CDS
    CCDS48993.1
    UniProtKB/TrEMBL
    Q6XPS7
    Related
    ENSMUSP00000033230.8, ENSMUST00000033230.8
    Conserved Domains (1) summary
    cl18945
    Location:40 → 388
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    117758775..117764352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534261.3 → XP_006534324.1  threonine aldolase 1 isoform X1

    Conserved Domains (1) summary
    cl18945
    Location:9 → 264
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous