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Inhca inhibitor of carbonic anhydrase [ Mus musculus (house mouse) ]

Gene ID: 71775, updated on 11-Apr-2024

Summary

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Official Symbol
Inhcaprovided by MGI
Official Full Name
inhibitor of carbonic anhydraseprovided by MGI
Primary source
MGI:MGI:1919025
See related
Ensembl:ENSMUSG00000033688 AllianceGenome:MGI:1919025
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ica; mICA; 1300017J02Rik
Summary
This gene is a member of the transferrin gene family. Unlike many members of that gene family it does not play a significant role in iron homeostasis but rather is an inhibitor of carbonic anhydrase. This gene arose as a tandem duplicate of the adjacent transferrin gene sometime after the divergence of monotremes and therian mammals but before the diversification of placental mammals. This gene subsequently became a pseudogene in monkeys and apes. In lemurs and other strepsirrhine primates it possibly remains a protein coding gene. [provided by RefSeq, Oct 2021]
Expression
Biased expression in liver adult (RPKM 103.2), liver E18 (RPKM 82.3) and 4 other tissues See more
Orthologs
all
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Genomic context

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See Inhca in Genome Data Viewer
Location:
9 F1; 9 55.1 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (103127722..103165496, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (103250523..103288297, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene transferrin Neighboring gene predicted gene, 53542 Neighboring gene predicted gene, 31701 Neighboring gene STARR-seq mESC enhancer starr_25089 Neighboring gene topoisomerase (DNA) II binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_25090 Neighboring gene STARR-positive B cell enhancer ABC_E573 Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesis. Mason AB, et al. Biochemistry, 2008 Sep 16. PMID 18712936, Free PMC Article
  2. A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase. Wang F, et al. Biochem J, 2007 Aug 15. PMID 17511619, Free PMC Article
  3. Multiple polymorphic loci determine basal hepatic and splenic iron status in mice. Grant GR, et al. Hepatology, 2006 Jul. PMID 16799992
  4. Parathyroid hormone regulates fetal-placental mineral homeostasis. Simmonds CS, et al. J Bone Miner Res, 2010 Mar. PMID 19968565
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Murine inhibitor of carbonic anhydrase was a glycoprotein that associated with carbonic anhydrase in a 1:1 stoichiometry.[ICA]
    Title: A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables iron ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inhibitor of carbonic anhydrase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027918.2 → NP_082194.1  inhibitor of carbonic anhydrase precursor

    See identical proteins and their annotated locations for NP_082194.1

    Status: PROVISIONAL

    Source sequence(s)
    AK005035
    Consensus CDS
    CCDS23452.1
    UniProtKB/Swiss-Prot
    Q9DBD0
    UniProtKB/TrEMBL
    Q8VC96
    Related
    ENSMUSP00000035163.4, ENSMUST00000035163.10
    Conserved Domains (4) summary
    smart00094
    Location:355 → 685
    TR_FER; Transferrin
    cd13617
    Location:352 → 684
    PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
    cd13618
    Location:24 → 346
    PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
    pfam00405
    Location:25 → 346
    Transferrin; Transferrin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    103127722..103165496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511835.4 → XP_006511898.1  inhibitor of carbonic anhydrase isoform X1

    Conserved Domains (2) summary
    cd13617
    Location:120 → 452
    PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
    cl21456
    Location:1 → 114
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBD0.1 GenPept UniProtKB/Swiss-Prot:Q9DBD0

Gene LinkOut

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