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Shroom1 shroom family member 1 [ Mus musculus (house mouse) ]

Gene ID: 71774, updated on 5-Mar-2024

Summary

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Official Symbol
Shroom1provided by MGI
Official Full Name
shroom family member 1provided by MGI
Primary source
MGI:MGI:1919024
See related
Ensembl:ENSMUSG00000018387 AllianceGenome:MGI:1919024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Apx; Shrm1
Summary
Enables actin filament binding activity and myosin II binding activity. Involved in actin filament bundle assembly and cell morphogenesis. Predicted to be located in cytoplasm and microtubule. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Orthologous to human SHROOM1 (shroom family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 13.1), placenta adult (RPKM 5.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 31.95 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53347904..53358593)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53457093..53467766)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E76 Neighboring gene growth differentiation factor 9 Neighboring gene predicted gene 10447 Neighboring gene sosondowah ankyrin repeat domain family member A Neighboring gene predicted gene 9945 Neighboring gene predicted gene, 19835

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The shroom family proteins play broad roles in the morphogenesis of thickened epithelial sheets. Lee C, et al. Dev Dyn, 2009 Jun. PMID 19384856, Free PMC Article
  2. Shroom expression is attenuated in pulmonary arterial hypertension. Sevilla-Pérez J, et al. Eur Respir J, 2008 Oct. PMID 18550613
  3. Suppression of SHROOM1 Improves In Vitro and In Vivo Gene Integration by Promoting Homology-Directed Repair. Zhao Z, et al. Int J Mol Sci, 2020 Aug 13. PMID 32823670, Free PMC Article
  4. Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction. Mohan S, et al. Mol Biol Cell, 2012 Jun. PMID 22493320, Free PMC Article
  5. Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins. Dietz ML, et al. J Biol Chem, 2006 Jul 21. PMID 16684770

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suppression of SHROOM1 Improves In Vitro and In Vivo Gene Integration by Promoting Homology-Directed Repair.
    Title: Suppression of SHROOM1 Improves In Vitro and In Vivo Gene Integration by Promoting Homology-Directed Repair.
  2. The structure of Shrm domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm function, is reported.
    Title: Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.
  3. Shroom localises exclusively to pulmonary smooth muscle cells and is attenuated in pulmonary arterial hypertension
    Title: Shroom expression is attenuated in pulmonary arterial hypertension.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 1300007L22Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin II binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament bundle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in apical junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein Shroom1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290789.1 → NP_001277718.1  protein Shroom1 isoform 2

    See identical proteins and their annotated locations for NP_001277718.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the central coding region but maintains reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK035462, AK134332, AL596095
    Consensus CDS
    CCDS70182.1
    UniProtKB/TrEMBL
    D3Z3D5
    Related
    ENSMUSP00000018531.6, ENSMUST00000018531.12
    Conserved Domains (2) summary
    pfam08687
    Location:456 → 731
    ASD2; Apx/Shroom domain ASD2
    pfam08688
    Location:140 → 239
    ASD1; Apx/Shroom domain ASD1

  2. NM_027917.3 → NP_082193.2  protein Shroom1 isoform 1

    See identical proteins and their annotated locations for NP_082193.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK035462, AK134332, AL596095
    Consensus CDS
    CCDS24680.2
    UniProtKB/Swiss-Prot
    B1AQY5, B1AQY6, Q5SX79, Q5SX83, Q99JP8
    UniProtKB/TrEMBL
    D3Z3D5
    Related
    ENSMUSP00000104641.3, ENSMUST00000109013.9
    Conserved Domains (2) summary
    pfam08687
    Location:519 → 794
    ASD2; Apx/Shroom domain ASD2
    pfam08688
    Location:140 → 239
    ASD1; Apx/Shroom domain ASD1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    53347904..53358593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534259.5 → XP_006534322.1  protein Shroom1 isoform X1

    UniProtKB/TrEMBL
    D3Z3D5
    Related
    ENSMUSP00000090802.5, ENSMUST00000093114.5
    Conserved Domains (2) summary
    pfam08687
    Location:519 → 772
    ASD2; Apx/Shroom domain ASD2
    pfam08688
    Location:140 → 244
    ASD1; Apx/Shroom domain ASD1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SX79.2 GenPept UniProtKB/Swiss-Prot:Q5SX79

Gene LinkOut

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