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Ap2b1 adaptor-related protein complex 2, beta 1 subunit [ Mus musculus (house mouse) ]

Gene ID: 71770, updated on 21-Apr-2024

Summary

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Official Symbol
Ap2b1provided by MGI
Official Full Name
adaptor-related protein complex 2, beta 1 subunitprovided by MGI
Primary source
MGI:MGI:1919020
See related
Ensembl:ENSMUSG00000035152 AllianceGenome:MGI:1919020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AP105B; 1300012O03Rik
Summary
Predicted to enable clathrin binding activity. Involved in clathrin-dependent endocytosis and postsynaptic neurotransmitter receptor internalization. Acts upstream of or within circulatory system development and kidney development. Part of AP-2 adaptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AP2B1 (adaptor related protein complex 2 subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 73.6), CNS E18 (RPKM 36.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 C; 11 50.3 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83189545..83295861)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83298719..83405035)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene schlafen 14 Neighboring gene STARR-positive B cell enhancer ABC_E1424 Neighboring gene STARR-positive B cell enhancer ABC_E8435 Neighboring gene expressed sequence AA465934 Neighboring gene STARR-seq mESC enhancer starr_30193 Neighboring gene expressed sequence AI450353 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene STARR-seq mESC enhancer starr_30196 Neighboring gene predicted gene, 23951 Neighboring gene RAS-like, family 10, member B Neighboring gene growth arrest-specific 2 like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate. Li W, et al. Cleft Palate Craniofac J, 2010 Nov. PMID 20500056, Free PMC Article
  2. A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells. Thornhill PB, et al. FEBS Lett, 2007 Sep 18. PMID 17761170
  3. The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin. Rappoport JZ, et al. J Biol Chem, 2003 Nov 28. PMID 14530274
  4. Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region. Tebar F, et al. J Biol Chem, 1997 Jun 13. PMID 9182572
  5. Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons. Bianchetta MJ, et al. J Neurosci, 2011 Aug 17. PMID 21849563, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the AP-2 complex is not associated with the endocytosed plasma membrane-associated clathrin
    Title: The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (2)  1 citation
  • Targeted (1) 
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin-dependent endocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic neurotransmitter receptor internalization NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of AP-2 adaptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of clathrin adaptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of clathrin coat ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in extrinsic component of presynaptic endocytic zone membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
AP-2 complex subunit beta
Names
adapter-related protein complex 2 beta subunit
adapter-related protein complex 2 subunit beta
adaptor protein complex AP-2 subunit beta
adaptor-related protein complex 2 subunit beta
beta-2-adaptin
beta-adaptin
beta2-adaptin
clathrin assembly protein complex 2 beta large chain
plasma membrane adaptor HA2/AP2 adaptin beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035854.2 → NP_001030931.1  AP-2 complex subunit beta isoform a

    See identical proteins and their annotated locations for NP_001030931.1

    Status: VALIDATED

    Source sequence(s)
    AK138434, AL603711
    Consensus CDS
    CCDS25161.1
    UniProtKB/TrEMBL
    H3BIY9, Q5SWR1
    Related
    ENSMUSP00000018875.7, ENSMUST00000018875.13
    Conserved Domains (4) summary
    smart00809
    Location:731 → 831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840 → 950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  2. NM_027915.3 → NP_082191.1  AP-2 complex subunit beta isoform b

    See identical proteins and their annotated locations for NP_082191.1

    Status: VALIDATED

    Source sequence(s)
    AK004975, AK138434, AL603711
    Consensus CDS
    CCDS25162.1
    UniProtKB/Swiss-Prot
    Q80XJ4, Q9DBG3
    UniProtKB/TrEMBL
    H3BIY9
    Related
    ENSMUSP00000070714.8, ENSMUST00000065692.14
    Conserved Domains (4) summary
    smart00809
    Location:717 → 817
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:826 → 936
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    83189545..83295861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314772.3 → XP_017170261.1  AP-2 complex subunit beta isoform X1

    UniProtKB/TrEMBL
    H3BIY9, Q5SWR1
    Conserved Domains (4) summary
    smart00809
    Location:731 → 831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840 → 950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  2. XM_006534258.5 → XP_006534321.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006534321.1

    UniProtKB/TrEMBL
    H3BIY9, Q5SWR1
    Related
    ENSMUSP00000135445.2, ENSMUST00000176523.2
    Conserved Domains (4) summary
    smart00809
    Location:731 → 831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840 → 950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  3. XM_036156996.1 → XP_036012889.1  AP-2 complex subunit beta isoform X1

    UniProtKB/TrEMBL
    H3BIY9, Q5SWR1
    Conserved Domains (4) summary
    smart00809
    Location:731 → 831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840 → 950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBG3.1 GenPept UniProtKB/Swiss-Prot:Q9DBG3

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