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Vwce von Willebrand factor C and EGF domains [ Mus musculus (house mouse) ]

Gene ID: 71768, updated on 5-Mar-2024

Summary

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Official Symbol
Vwceprovided by MGI
Official Full Name
von Willebrand factor C and EGF domainsprovided by MGI
Primary source
MGI:MGI:1919018
See related
Ensembl:ENSMUSG00000043789 AllianceGenome:MGI:1919018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300015B04Rik
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cellular response to virus. Predicted to be located in extracellular region. Predicted to be active in cytoplasm. Is expressed in left lung; mandible; maxilla; orbito-sphenoid; and right lung. Orthologous to human VWCE (von Willebrand factor C and EGF domains). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 7.7), duodenum adult (RPKM 7.7) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 6.87 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10611582..10643577)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10634218..10666213)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 138 Neighboring gene STARR-positive B cell enhancer ABC_E9455 Neighboring gene cytochrome b561 family, member A3 Neighboring gene triokinase, FMN cyclase Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene damage specific DNA binding protein 1 Neighboring gene RIKEN cDNA 4930524O05 gene Neighboring gene STARR-seq mESC enhancer starr_45554 Neighboring gene RIKEN cDNA 2210404E10 gene Neighboring gene pepsinogen 5, group I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. Yang H, et al. Cell, 2012 Apr 27. PMID 22541431
  2. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
von Willebrand factor C and EGF domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027913.2 → NP_082189.1  von Willebrand factor C and EGF domain-containing protein precursor

    See identical proteins and their annotated locations for NP_082189.1

    Status: VALIDATED

    Source sequence(s)
    AC132247
    Consensus CDS
    CCDS50390.1
    UniProtKB/Swiss-Prot
    E9QME6, Q3U515
    Related
    ENSMUSP00000056958.8, ENSMUST00000055115.9
    Conserved Domains (4) summary
    smart00179
    Location:220 → 262
    EGF_CA; Calcium-binding EGF-like domain
    smart00214
    Location:564 → 617
    VWC; von Willebrand factor (vWF) type C domain
    pfam12662
    Location:200 → 223
    cEGF; Complement Clr-like EGF-like
    cl17735
    Location:493 → 551
    VWC; von Willebrand factor type C domain

RNA

  1. NR_153778.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132247

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10611582..10643577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527347.4 → XP_006527410.1  von Willebrand factor C and EGF domain-containing protein isoform X1

    Conserved Domains (5) summary
    smart00179
    Location:220 → 262
    EGF_CA; Calcium-binding EGF-like domain
    smart00214
    Location:564 → 617
    VWC; von Willebrand factor (vWF) type C domain
    PHA03247
    Location:717 → 916
    PHA03247; large tegument protein UL36; Provisional
    cl17735
    Location:493 → 551
    VWC; von Willebrand factor type C domain
    pfam12662
    Location:200 → 223
    cEGF; Complement Clr-like EGF-like

  2. XM_006527348.4 → XP_006527411.1  von Willebrand factor C and EGF domain-containing protein isoform X2

    Conserved Domains (5) summary
    smart00179
    Location:220 → 262
    EGF_CA; Calcium-binding EGF-like domain
    smart00214
    Location:613 → 668
    VWC; von Willebrand factor (vWF) type C domain
    PHA03247
    Location:707 → 914
    PHA03247; large tegument protein UL36; Provisional
    cl17735
    Location:493 → 551
    VWC; von Willebrand factor type C domain
    pfam12662
    Location:200 → 223
    cEGF; Complement Clr-like EGF-like

  3. XM_006527349.4 → XP_006527412.1  von Willebrand factor C and EGF domain-containing protein isoform X3

    Conserved Domains (2) summary
    smart00214
    Location:111 → 164
    VWC; von Willebrand factor (vWF) type C domain
    PHA03247
    Location:262 → 473
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_003952821.1 RNA Sequence

  2. XR_386516.4 RNA Sequence

  3. XR_386514.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U515.2 GenPept UniProtKB/Swiss-Prot:Q3U515

Gene LinkOut

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