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Dhdh dihydrodiol dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 71755, updated on 5-Mar-2024

Summary

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Official Symbol
Dhdhprovided by MGI
Official Full Name
dihydrodiol dehydrogenaseprovided by MGI
Primary source
MGI:MGI:1919005
See related
Ensembl:ENSMUSG00000011382 AllianceGenome:MGI:1919005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Xld1; Xld-1; 1300018L09Rik; B830008H07Rik
Summary
Enables D-xylose 1-dehydrogenase (NADP+) activity. Acts upstream of or within D-xylose catabolic process. Is expressed in nervous system and respiratory system. Orthologous to human DHDH (dihydrodiol dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 18.6), subcutaneous fat pad adult (RPKM 17.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 29.32 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45122380..45138312, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45472956..45488888, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18840 Neighboring gene ferritin light polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_18841 Neighboring gene BCL2-associated X protein Neighboring gene TUB like protein 2 Neighboring gene nucleobindin 1 Neighboring gene STARR-positive B cell enhancer ABC_E2239 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52781513-52781717 Neighboring gene protein phosphatase 1, regulatory subunit 15A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Xylose dehydrogenase-1, a new gene on mouse chromosome 7. Newton MF, et al. Biochem Genet, 1982 Aug. PMID 6753830
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-xylose 1-dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-xylose 1-dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-xylose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within D-xylose catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Names
D-xylose 1-dehydrogenase
D-xylose-NADP dehydrogenase
dihydrodiol dehydrogenase (dimeric)
dimeric dihydrodiol dehydrogenase
xylose dehydrogenase 1
NP_082179.1
XP_006541262.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027903.4 → NP_082179.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

    See identical proteins and their annotated locations for NP_082179.1

    Status: VALIDATED

    Source sequence(s)
    AC151602
    Consensus CDS
    CCDS21247.1
    UniProtKB/Swiss-Prot
    Q14B09, Q9DBB8
    UniProtKB/TrEMBL
    Q8K0E9
    Related
    ENSMUSP00000011526.5, ENSMUST00000011526.7
    Conserved Domains (2) summary
    COG0673
    Location:1 → 325
    MviM; Predicted dehydrogenase [General function prediction only]
    pfam01408
    Location:3 → 121
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45122380..45138312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541199.4 → XP_006541262.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X1

    UniProtKB/TrEMBL
    Q8K0E9
    Conserved Domains (1) summary
    COG0673
    Location:1 → 368
    MviM; Predicted dehydrogenase [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBB8.1 GenPept UniProtKB/Swiss-Prot:Q9DBB8

Gene LinkOut

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