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R3hdm2 R3H domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 71750, updated on 5-Mar-2024

Summary

Official Symbol
R3hdm2provided by MGI
Official Full Name
R3H domain containing 2provided by MGI
Primary source
MGI:MGI:1919000
See related
Ensembl:ENSMUSG00000025404 AllianceGenome:MGI:1919000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1002; 1300003K24Rik
Summary
Predicted to enable nucleic acid binding activity. Predicted to be located in nucleus. Is expressed in dorsal root ganglion; glossopharyngeal ganglion; trigeminal ganglion; and vagus ganglion. Orthologous to human R3HDM2 (R3H domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 25.1), frontal lobe adult (RPKM 22.1) and 28 other tissues See more
Orthologs
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Genomic context

Location:
10 D3; 10 74.5 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127216201..127335253)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127380332..127499384)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene inhibin beta-E Neighboring gene inhibin beta-C Neighboring gene predicted gene, 23819 Neighboring gene STARR-positive B cell enhancer mm9_chr10:126945421-126945721 Neighboring gene STARR-positive B cell enhancer ABC_E10656 Neighboring gene STARR-positive B cell enhancer ABC_E2342 Neighboring gene SH3 and cysteine rich domain 3 Neighboring gene Ndufa4, mitochondrial complex associated like 2 Neighboring gene serine hydroxymethyltransferase 2 (mitochondrial)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC144089

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
R3H domain-containing protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168292.1NP_001161764.1  R3H domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001161764.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK043545, AK122416, BC053099, CJ078477
    Consensus CDS
    CCDS48717.1
    UniProtKB/Swiss-Prot
    Q80TM6, Q80YB1, Q8BLS5, Q9CW50
    Related
    ENSMUSP00000076303.6, ENSMUST00000077046.12
    Conserved Domains (3) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:451800
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:250303
    SUZ; SUZ domain
  2. NM_001168293.1NP_001161765.1  R3H domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001161765.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AK043545, BC053099, BC117927
    Consensus CDS
    CCDS48718.1
    UniProtKB/TrEMBL
    Q148X5
    Related
    ENSMUSP00000128659.2, ENSMUST00000170336.8
    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:419768
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  3. NM_001359243.1NP_001346172.1  R3H domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK043545, BC043083, BC053099, CJ078477, CN531481, CX562801
    Consensus CDS
    CCDS48717.1
    UniProtKB/Swiss-Prot
    Q80TM6, Q80YB1, Q8BLS5, Q9CW50
    Conserved Domains (3) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:451800
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:250303
    SUZ; SUZ domain
  4. NM_001359244.1NP_001346173.1  R3H domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK043545, BC043083, BC053099, CB527965, CJ078477, CN531481, CX562801
    Consensus CDS
    CCDS48718.1
    UniProtKB/TrEMBL
    Q148X5
    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:419768
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  5. NM_001359245.1NP_001346174.1  R3H domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114678, AK043545, BC043083, BC053099, BY239444, CN531481
    Consensus CDS
    CCDS48718.1
    UniProtKB/TrEMBL
    Q148X5
    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:419768
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  6. NM_001359246.1NP_001346175.1  R3H domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC114678, AK043545, BC043083, BC053099
    Consensus CDS
    CCDS88102.1
    Related
    ENSMUSP00000100886.3, ENSMUST00000105251.9
    Conserved Domains (3) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:433782
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:250303
    SUZ; SUZ domain
  7. NM_027900.4NP_082176.4  R3H domain-containing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an in-frame exon, and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC114678, AK043545, BC053099
    Consensus CDS
    CCDS24241.1
    UniProtKB/Swiss-Prot
    Q80TM6
    Related
    ENSMUSP00000069724.7, ENSMUST00000064793.13
    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:424820
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127216201..127335253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514153.2XP_006514216.1  R3H domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006514216.1

    UniProtKB/Swiss-Prot
    Q80TM6, Q80YB1, Q8BLS5, Q9CW50
    Conserved Domains (3) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:451800
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:250303
    SUZ; SUZ domain
  2. XM_006514162.4XP_006514225.1  R3H domain-containing protein 2 isoform X6

    See identical proteins and their annotated locations for XP_006514225.1

    UniProtKB/Swiss-Prot
    Q80TM6
    Conserved Domains (3) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:431748
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:250303
    SUZ; SUZ domain
  3. XM_006514160.3XP_006514223.1  R3H domain-containing protein 2 isoform X4

    Conserved Domains (3) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:449766
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:250303
    SUZ; SUZ domain
  4. XM_006514158.3XP_006514221.1  R3H domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q80TM6
    Related
    ENSMUSP00000100885.3, ENSMUST00000105250.9
    Conserved Domains (3) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:433782
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:250303
    SUZ; SUZ domain
  5. XM_006514163.3XP_006514226.1  R3H domain-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    E9Q9D6
    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:417734
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  6. XM_006514161.4XP_006514224.1  R3H domain-containing protein 2 isoform X5

    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:401750
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  7. XM_006514164.4XP_006514227.1  R3H domain-containing protein 2 isoform X8

    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:399716
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  8. XM_036156025.1XP_036011918.1  R3H domain-containing protein 2 isoform X9

    UniProtKB/TrEMBL
    Q5XKA9
    Conserved Domains (1) summary
    pfam09606
    Location:52341
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  9. XM_006514154.5XP_006514217.1  R3H domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006514217.1

    UniProtKB/Swiss-Prot
    Q80TM6, Q80YB1, Q8BLS5, Q9CW50
    Conserved Domains (3) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:451800
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:250303
    SUZ; SUZ domain
  10. XM_036156023.1XP_036011916.1  R3H domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    Q148X5
    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:419768
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  11. XM_030245292.2XP_030101152.1  R3H domain-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    E9Q9D6
    Related
    ENSMUSP00000131007.2, ENSMUST00000164831.8
    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:417734
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  12. XM_030245287.2XP_030101147.1  R3H domain-containing protein 2 isoform X5

    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:401750
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  13. XM_006514152.3XP_006514215.1  R3H domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006514215.1

    UniProtKB/Swiss-Prot
    Q80TM6, Q80YB1, Q8BLS5, Q9CW50
    Related
    ENSMUSP00000126608.2, ENSMUST00000166820.8
    Conserved Domains (3) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:451800
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:250303
    SUZ; SUZ domain
  14. XM_030245291.2XP_030101151.1  R3H domain-containing protein 2 isoform X6

    Related
    ENSMUSP00000100884.3, ENSMUST00000105249.9
    Conserved Domains (3) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:431748
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:250303
    SUZ; SUZ domain
  15. XM_030245293.1XP_030101153.1  R3H domain-containing protein 2 isoform X8

    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:399716
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  16. XM_030245289.2XP_030101149.1  R3H domain-containing protein 2 isoform X5

    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:401750
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  17. XM_006514157.4XP_006514220.1  R3H domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006514220.1

    UniProtKB/Swiss-Prot
    Q80TM6, Q80YB1, Q8BLS5, Q9CW50
    Conserved Domains (3) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:451800
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:250303
    SUZ; SUZ domain
  18. XM_030245288.2XP_030101148.1  R3H domain-containing protein 2 isoform X5

    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:401750
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  19. XM_006514156.4XP_006514219.1  R3H domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006514219.1

    UniProtKB/Swiss-Prot
    Q80TM6, Q80YB1, Q8BLS5, Q9CW50
    Conserved Domains (3) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:451800
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:250303
    SUZ; SUZ domain
  20. XM_030245290.2XP_030101150.1  R3H domain-containing protein 2 isoform X5

    Conserved Domains (2) summary
    cd02642
    Location:168229
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:401750
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  21. XM_036156024.1XP_036011917.1  R3H domain-containing protein 2 isoform X9

    UniProtKB/TrEMBL
    Q5XKA9
    Conserved Domains (1) summary
    pfam09606
    Location:52341
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  22. XM_030245294.1XP_030101154.1  R3H domain-containing protein 2 isoform X9

    UniProtKB/TrEMBL
    Q5XKA9
    Conserved Domains (1) summary
    pfam09606
    Location:52341
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  23. XM_030245295.2XP_030101155.1  R3H domain-containing protein 2 isoform X10

    UniProtKB/TrEMBL
    Q5XKA9
    Conserved Domains (1) summary
    pfam09606
    Location:6288
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal