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Rgl3 ral guanine nucleotide dissociation stimulator-like 3 [ Mus musculus (house mouse) ]

Gene ID: 71746, updated on 11-Apr-2024

Summary

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Official Symbol
Rgl3provided by MGI
Official Full Name
ral guanine nucleotide dissociation stimulator-like 3provided by MGI
Primary source
MGI:MGI:1918996
See related
Ensembl:ENSMUSG00000040146 AllianceGenome:MGI:1918996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mFLJ00153; 1300003D20Rik
Summary
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in positive regulation of GTPase activity and signal transduction. Predicted to act upstream of or within small GTPase mediated signal transduction. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human RGL3 (ral guanine nucleotide dissociation stimulator like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 46.3), kidney adult (RPKM 22.1) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Rgl3 in Genome Data Viewer
Location:
9 A3; 9 7.96 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21882475..21900765, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21971179..21989468, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45914 Neighboring gene SWIM type zinc finger 7 associated protein 1 Neighboring gene erythropoietin receptor Neighboring gene predicted gene, 36414 Neighboring gene outer dynein arm docking complex subunit 3 Neighboring gene protein kinase C substrate 80K-H

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth. Ehrhardt GR, et al. Oncogene, 2001 Jan 11. PMID 11313946
  2. Identification of Rgl3 as a potential binding partner for Rap-family small G-proteins and profilin II. Xu J, et al. Cell Signal, 2007 Jul. PMID 17382517
  3. A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras. Shao H, et al. J Biol Chem, 2000 Sep 1. PMID 10869344
  4. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ral guanine nucleotide dissociation stimulator-like 3
Names
RPM
Ral guanine-nucleotide exchange factor
RalGDS-like protein 3
ralGDS-like 3
ralGDS-related effector protein of M-Ras
ras pathway modulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023622.5 → NP_076111.2  ral guanine nucleotide dissociation stimulator-like 3

    See identical proteins and their annotated locations for NP_076111.2

    Status: VALIDATED

    Source sequence(s)
    AC163623
    Consensus CDS
    CCDS22916.1
    UniProtKB/Swiss-Prot
    Q3UYI5, Q6KAR7, Q8BKD3, Q924M8, Q9DBL8, Q9JID4
    Related
    ENSMUSP00000035726.7, ENSMUST00000045726.8
    Conserved Domains (3) summary
    cd06224
    Location:73 → 199
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00153
    Location:612 → 697
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:244 → 503
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21882475..21900765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510613.3 → XP_006510676.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X2

    Conserved Domains (3) summary
    smart00147
    Location:165 → 424
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd17212
    Location:532 → 618
    RA_RGL3; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) and similar proteins
    cl02520
    Location:56 → 120
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

  2. XM_036155300.1 → XP_036011193.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X1

    Conserved Domains (3) summary
    cd06224
    Location:73 → 199
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:244 → 503
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cl28922
    Location:579 → 646
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_036155301.1 → XP_036011194.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X3

    Conserved Domains (3) summary
    smart00147
    Location:145 → 404
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd17212
    Location:512 → 598
    RA_RGL3; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) and similar proteins
    cl02520
    Location:36 → 100
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

  4. XM_030244617.1 → XP_030100477.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X2

    Conserved Domains (3) summary
    smart00147
    Location:165 → 424
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd17212
    Location:532 → 618
    RA_RGL3; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) and similar proteins
    cl02520
    Location:56 → 120
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

RNA

  1. XR_003948008.2 RNA Sequence

    Related
    ENSMUST00000214089.2

  2. XR_004935561.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UYI5.2 GenPept UniProtKB/Swiss-Prot:Q3UYI5

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