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Cul2 cullin 2 [ Mus musculus (house mouse) ]

Gene ID: 71745, updated on 5-Mar-2024

Summary

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Official Symbol
Cul2provided by MGI
Official Full Name
cullin 2provided by MGI
Primary source
MGI:MGI:1918995
See related
Ensembl:ENSMUSG00000024231 AllianceGenome:MGI:1918995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4106; 1300003D18Rik; 4932411N15Rik
Summary
Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Acts upstream of or within protein catabolic process. Located in nucleolus. Part of Cul2-RING ubiquitin ligase complex. Is expressed in cervical ganglion; cervico-thoracic ganglion; dorsal root ganglion; thoracic ganglion; and trigeminal ganglion. Orthologous to human CUL2 (cullin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 8.3), CNS E18 (RPKM 7.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cul2 in Genome Data Viewer
Location:
18 A1; 18 2.21 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (3382970..3436700)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (3382970..3436700)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43653 Neighboring gene vomeronasal 1 receptor, 238 Neighboring gene STARR-seq mESC enhancer starr_43654 Neighboring gene STARR-seq mESC enhancer starr_43655 Neighboring gene STARR-positive B cell enhancer ABC_E5646 Neighboring gene cAMP responsive element modulator Neighboring gene predicted gene 6225 Neighboring gene STARR-seq mESC enhancer starr_43658 Neighboring gene profilin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43660 Neighboring gene STARR-positive B cell enhancer ABC_E10980 Neighboring gene BMP and activin membrane-bound inhibitor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Post-translational control of beige fat biogenesis by PRDM16 stabilization. Wang Q, et al. Nature, 2022 Sep. PMID 35978186, Free PMC Article
  2. Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses. Curtis VF, et al. FASEB J, 2015 Jan. PMID 25326537, Free PMC Article
  3. ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation. Okumura F, et al. Sci Rep, 2021 Oct 22. PMID 34686700, Free PMC Article
  4. TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation. Shiraishi S, et al. J Biol Chem, 2007 Mar 23. PMID 17242400
  5. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Zheng N, et al. Nature, 2002 Apr 18. PMID 11961546

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4106

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin ligase complex scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of VCB complex ISO
Inferred from Sequence Orthology
more info
  
part_of cullin-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cullin-2
Names
CUL-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360829.1 → NP_001347758.1  cullin-2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124336
    Consensus CDS
    CCDS29032.2
    UniProtKB/Swiss-Prot
    Q3TUR8, Q9D4H8
    UniProtKB/TrEMBL
    Q571A2
    Related
    ENSMUSP00000025073.6, ENSMUST00000025073.12
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:677 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  2. NM_029402.3 → NP_083678.2  cullin-2

    See identical proteins and their annotated locations for NP_083678.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124336, AK004875, AK144693, AK162910
    Consensus CDS
    CCDS29032.2
    UniProtKB/Swiss-Prot
    Q3TUR8, Q9D4H8
    UniProtKB/TrEMBL
    Q571A2
    Related
    ENSMUSP00000125403.2, ENSMUST00000162301.8
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:677 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    3382970..3436700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526275.5 → XP_006526338.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_006526338.1

    UniProtKB/Swiss-Prot
    Q3TUR8, Q9D4H8
    UniProtKB/TrEMBL
    Q571A2
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:677 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  2. XM_030250610.2 → XP_030106470.1  cullin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TUR8, Q9D4H8
    UniProtKB/TrEMBL
    Q571A2
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:677 → 735
    Cullin_Nedd8; Cullin protein neddylation domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4H8.2 GenPept UniProtKB/Swiss-Prot:Q9D4H8

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