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Smug1 single-strand selective monofunctional uracil DNA glycosylase [ Mus musculus (house mouse) ]

Gene ID: 71726, updated on 9-Mar-2024

Summary

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Official Symbol
Smug1provided by MGI
Official Full Name
single-strand selective monofunctional uracil DNA glycosylaseprovided by MGI
Primary source
MGI:MGI:1918976
See related
Ensembl:ENSMUSG00000036061 AllianceGenome:MGI:1918976
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200013B09Rik; A930006H09Rik
Summary
Predicted to enable DNA N-glycosylase activity; identical protein binding activity; and single-stranded DNA binding activity. Predicted to be involved in base-excision repair. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Is expressed in several structures, including lower urogenital tract; palatal shelf; reproductive system; retina layer; and urethra epithelium. Orthologous to human SMUG1 (single-strand-selective monofunctional uracil-DNA glycosylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 4.2), whole brain E14.5 (RPKM 3.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 F3; 15 58.2 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103061717..103077360, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103153290..103168939, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 28876 Neighboring gene predicted gene 10830 Neighboring gene Riken cDNA D930007P13 gene Neighboring gene STARR-positive B cell enhancer mm9_chr15:102993642-102993943 Neighboring gene STARR-seq mESC enhancer starr_39867 Neighboring gene chromobox 5 Neighboring gene STARR-seq mESC enhancer starr_39868 Neighboring gene heterogeneous nuclear ribonucleoprotein A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice. Carracedo S, et al. DNA Repair (Amst), 2022 Dec. PMID 36244177
  2. SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing. Kroustallaki P, et al. Cell Rep, 2019 Aug 13. PMID 31412240
  3. Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation. Dingler FA, et al. Eur J Immunol, 2014 Jul. PMID 24771041, Free PMC Article
  4. Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase. Nilsen H, et al. EMBO J, 2001 Aug 1. PMID 11483530, Free PMC Article
  5. C --> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases. An Q, et al. EMBO J, 2005 Jun 15. PMID 15902269, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice.
    Title: SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice.
  2. we showed that SMUG1 efficiently prevent genomic uracil accumulation, even in the presence of UNG, and identified mutational signatures associated with combined UNG and SMUG1 deficiency.
    Title: Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.
  3. Nonetheless, using a highly MSH2-dependent mechanism, Ung(-/-) Smug1(-/-) mice can still produce detectable levels of switched isotypes, especially IgG1
    Title: Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.
  4. SMUG1 is the dominant glycosylase responsible for 5-hydroxymethyluracil-excision in mice as well as the major UNG-backup for U-excision.
    Title: Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
  5. analysis of species specific differences between mouse and humans in regulation of SMUG1 and UNG2
    Title: Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.
  6. The structure and specificity of SMUG1 have been solved.
    Title: Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA N-glycosylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidized base lesion DNA N-glycosylase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
  
enables single-strand selective uracil DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
  
enables single-strand selective uracil DNA N-glycosylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables single-stranded DNA binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables uracil DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uracil DNA N-glycosylase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables uracil DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
  
enables uracil DNA N-glycosylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in base-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
single-strand selective monofunctional uracil DNA glycosylase
NP_082161.2
XP_006521478.1
XP_011244033.1
XP_011244034.1
XP_011244035.1
XP_017172241.1
XP_036015486.1
XP_036015487.1
XP_036015488.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027885.3 → NP_082161.2  single-strand selective monofunctional uracil DNA glycosylase

    See identical proteins and their annotated locations for NP_082161.2

    Status: PROVISIONAL

    Source sequence(s)
    AC162693
    Consensus CDS
    CCDS27898.1
    UniProtKB/Swiss-Prot
    Q6P5C5, Q9DBV1
    UniProtKB/TrEMBL
    Q3T9H8
    Related
    ENSMUSP00000155700.2, ENSMUST00000229377.2
    Conserved Domains (1) summary
    cd19374
    Location:31 → 260
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    103061717..103077360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245731.4 → XP_011244033.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    See identical proteins and their annotated locations for XP_011244033.1

    UniProtKB/Swiss-Prot
    Q6P5C5, Q9DBV1
    UniProtKB/TrEMBL
    Q3T9H8
    Conserved Domains (1) summary
    cd19374
    Location:31 → 260
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins

  2. XM_006521415.4 → XP_006521478.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    See identical proteins and their annotated locations for XP_006521478.1

    UniProtKB/Swiss-Prot
    Q6P5C5, Q9DBV1
    UniProtKB/TrEMBL
    Q3T9H8
    Related
    ENSMUSP00000155594.2, ENSMUST00000229371.2
    Conserved Domains (1) summary
    cd19374
    Location:31 → 260
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins

  3. XM_011245732.3 → XP_011244034.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    See identical proteins and their annotated locations for XP_011244034.1

    UniProtKB/Swiss-Prot
    Q6P5C5, Q9DBV1
    UniProtKB/TrEMBL
    Q3T9H8
    Conserved Domains (1) summary
    cd19374
    Location:31 → 260
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins

  4. XM_036159593.1 → XP_036015486.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    Q6P5C5, Q9DBV1
    UniProtKB/TrEMBL
    Q3T9H8
    Conserved Domains (1) summary
    cd19374
    Location:31 → 260
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins

  5. XM_011245733.3 → XP_011244035.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    See identical proteins and their annotated locations for XP_011244035.1

    UniProtKB/Swiss-Prot
    Q6P5C5, Q9DBV1
    UniProtKB/TrEMBL
    Q3T9H8
    Conserved Domains (1) summary
    cd19374
    Location:31 → 260
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins

  6. XM_036159594.1 → XP_036015487.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    Q6P5C5, Q9DBV1
    UniProtKB/TrEMBL
    Q3T9H8
    Conserved Domains (1) summary
    cd19374
    Location:31 → 260
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins

  7. XM_036159595.1 → XP_036015488.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    Q6P5C5, Q9DBV1
    UniProtKB/TrEMBL
    Q3T9H8
    Conserved Domains (1) summary
    cd19374
    Location:31 → 260
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins

  8. XM_017316752.1 → XP_017172241.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    Q6P5C5, Q9DBV1
    UniProtKB/TrEMBL
    Q3T9H8
    Conserved Domains (1) summary
    cd19374
    Location:31 → 260
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P5C5.1 GenPept UniProtKB/Swiss-Prot:Q6P5C5

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