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Dhx34 DExH-box helicase 34 [ Mus musculus (house mouse) ]

Gene ID: 71723, updated on 11-Apr-2024

Summary

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Official Symbol
Dhx34provided by MGI
Official Full Name
DExH-box helicase 34provided by MGI
Primary source
MGI:MGI:1918973
See related
Ensembl:ENSMUSG00000006019 AllianceGenome:MGI:1918973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ddx34; mKIAA0134; 1200013B07Rik; 1810012L18Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Is expressed in pancreas and pancreas tip epithelium. Orthologous to human DHX34 (DExH-box helicase 34). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 14.7), spleen adult (RPKM 13.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 8.76 cM; 7 A2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (15931145..15956005, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16197220..16222078, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 (sodium/calcium exchanger), member 2 Neighboring gene Meis homeobox 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16786573-16786682 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16792577-16792686 Neighboring gene STARR-positive B cell enhancer ABC_E1334 Neighboring gene STARR-seq mESC enhancer starr_18126 Neighboring gene STARR-positive B cell enhancer ABC_E9684 Neighboring gene predicted gene, 26473 Neighboring gene complement component 5a receptor 2 Neighboring gene complement component 5a receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DHX34
Names
DEAH (Asp-Glu-Ala-His) box polypeptide 34
DEAH box protein 34
NP_001272860.1
NP_001272861.1
NP_082159.3
XP_006540432.1
XP_006540434.1
XP_017167800.1
XP_030098852.1
XP_030098853.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285931.1 → NP_001272860.1  probable ATP-dependent RNA helicase DHX34

    See identical proteins and their annotated locations for NP_001272860.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK004733, BC058370, BC080856, CB525602
    Consensus CDS
    CCDS39783.1
    UniProtKB/TrEMBL
    A0A0R4J217, Q66JM5
    Related
    ENSMUSP00000113393.2, ENSMUST00000119102.8
    Conserved Domains (2) summary
    COG1643
    Location:153 → 688
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam07717
    Location:800 → 911
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  2. NM_001285932.1 → NP_001272861.1  probable ATP-dependent RNA helicase DHX34

    See identical proteins and their annotated locations for NP_001272861.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK004733, BC080856, CB525602
    Consensus CDS
    CCDS39783.1
    UniProtKB/TrEMBL
    A0A0R4J217, Q66JM5
    Related
    ENSMUSP00000092410.3, ENSMUST00000094816.3
    Conserved Domains (2) summary
    COG1643
    Location:153 → 688
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam07717
    Location:800 → 911
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  3. NM_027883.3 → NP_082159.3  probable ATP-dependent RNA helicase DHX34

    See identical proteins and their annotated locations for NP_082159.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK004733
    Consensus CDS
    CCDS39783.1
    UniProtKB/TrEMBL
    A0A0R4J217, Q66JM5
    Related
    ENSMUSP00000126915.2, ENSMUST00000163968.8
    Conserved Domains (2) summary
    COG1643
    Location:153 → 688
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam07717
    Location:800 → 911
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    15931145..15956005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242992.2 → XP_030098852.1  probable ATP-dependent RNA helicase DHX34 isoform X2

    Conserved Domains (3) summary
    smart00847
    Location:27 → 73
    HA2; Helicase associated domain (HA2) Add an annotation
    TIGR01967
    Location:31 → 124
    DEAH_box_HrpA; RNA helicase HrpA
    pfam07717
    Location:226 → 336
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  2. XM_017312311.2 → XP_017167800.1  probable ATP-dependent RNA helicase DHX34 isoform X1

    UniProtKB/TrEMBL
    A0A0R4J217, Q66JM5
    Conserved Domains (2) summary
    COG1643
    Location:153 → 688
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam07717
    Location:800 → 911
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  3. XM_006540369.4 → XP_006540432.1  probable ATP-dependent RNA helicase DHX34 isoform X1

    See identical proteins and their annotated locations for XP_006540432.1

    UniProtKB/TrEMBL
    A0A0R4J217, Q66JM5
    Conserved Domains (2) summary
    COG1643
    Location:153 → 688
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam07717
    Location:800 → 911
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  4. XM_030242993.1 → XP_030098853.1  probable ATP-dependent RNA helicase DHX34 isoform X4

    Conserved Domains (2) summary
    smart00847
    Location:1 → 54
    HA2; Helicase associated domain (HA2) Add an annotation
    pfam07717
    Location:207 → 317
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  5. XM_006540371.5 → XP_006540434.1  probable ATP-dependent RNA helicase DHX34 isoform X3

    Conserved Domains (3) summary
    smart00847
    Location:17 → 64
    HA2; Helicase associated domain (HA2) Add an annotation
    TIGR01967
    Location:22 → 115
    DEAH_box_HrpA; RNA helicase HrpA
    pfam07717
    Location:217 → 327
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RNA

  1. XR_391100.5 RNA Sequence

  2. XR_003946563.1 RNA Sequence

  3. XR_003946564.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBV3.2 GenPept UniProtKB/Swiss-Prot:Q9DBV3

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