Mus81 MUS81 structure-specific endonuclease subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mus81provided by MGI
Official Full Name: MUS81 structure-specific endonuclease subunitprovided by MGI
Primary source: MGI:MGI:1918961
See related: Ensembl:ENSMUSG00000024906 AllianceGenome:MGI:1918961
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1200008A18Rik
Summary: Predicted to enable 3'-flap endonuclease activity. Predicted to be involved in DNA recombination; mitotic intra-S DNA damage checkpoint signaling; and osteoblast proliferation. Predicted to act upstream of or within DNA catabolic process, endonucleolytic; DNA repair; and response to intra-S DNA damage checkpoint signaling. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus. Used to study Marfan syndrome; arterial tortuosity syndrome; and pulmonary emphysema. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 19.3), cerebellum adult (RPKM 15.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.34 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5532589..5538461, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5482561..5488389, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A study of protective effects of Mus81 in preeclampsia.
Title: A study of protective effects of Mus81 in preeclampsia.
this study shows that immune rejection of prostate cancer cells relies on Mus81 and STING
Title: The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells.
Our study highlights the importance of the cooperation between Rad54 and Mus81 for mediating DNA DSB repair and restraining chromosome missegregation.
Title: Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.
Mus81 knockdown improves the chemosensitivity of HCC cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway, suggesting Mus81 as a novel therapeutic target for HCC.
Title: Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway.
Using mice deficient in both Mus81 and the FA pathway protein FancC, we show both proteins cooperate in parallel pathways, as concomitant loss of FancC and Mus81 triggered cell-type-specific proliferation arrest, apoptosis and DNA damage accumulation in utero.
Title: Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair.
Data indicate that SLX1 and MUS81-EME1 nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4.
Title: Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.
FBH1 helicase activity is required to eliminate cells with excessive replication stress through the generation of MUS81-induced DNA double-strand breaks.
Title: FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.
data indicate that an important role for Chk2 is maintaining lymphocyte development and that dual inactivation of Chk2 and Mus81 remarkably inhibits cancer
Title: Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.
Fndings support a role for Mus81 in the resolution of replication-associated DNA damage associated with this genotoxic agent, by converting Cr[VI]-DNA lesions into a form more amenable for homologous recombination.
Title: A role for Mus81 in the repair of chromium-induced DNA damage.
Analysis of meiotic progression in Mus81-nullizygous mice, and our results implicate the MUS81 pathway as a regulator of crossover frequency and placement in mammals.
Title: MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI182501 (e-PCR)
- UniSTS:160773

AW045863 (e-PCR)
- UniSTS:181159

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-flap endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-flap endonuclease activity	ISO Inferred from Sequence Orthology more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to crossover junction DNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	ISO Inferred from Sequence Orthology more info	PubMed
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via break-induced replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic intra-S DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info
involved_in resolution of meiotic recombination intermediates	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Holliday junction resolvase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of endodeoxyribonuclease complex	ISO Inferred from Sequence Orthology more info
located_in nuclear replication fork	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in replication fork	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: crossover junction endonuclease MUS81

Names: MUS81 endonuclease homolog

NP_082153.3

EC 3.1.22.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027877.4 → NP_082153.3 crossover junction endonuclease MUS81

See identical proteins and their annotated locations for NP_082153.3

Status: VALIDATED

Source sequence(s)

AA014278, AC126029, AK004647, AK145858, BY208661

Consensus CDS

CCDS29467.1

UniProtKB/Swiss-Prot

Q8R356, Q91ZJ0

UniProtKB/TrEMBL

F8WIN9

Related

ENSMUSP00000114895.2, ENSMUST00000124334.8

Conserved Domains (2) summary

COG1948
Location:248 → 515

MUS81; ERCC4-type nuclease [Replication, recombination and repair]

pfam02732
Location:273 → 415

ERCC4; ERCC4 domain

RNA

NR_153768.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC126029, AK145858

Related

ENSMUST00000025841.4
NR_153769.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC126029