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Slc46a3 solute carrier family 46, member 3 [ Mus musculus (house mouse) ]

Gene ID: 71706, updated on 11-Apr-2024

Summary

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Official Symbol
Slc46a3provided by MGI
Official Full Name
solute carrier family 46, member 3provided by MGI
Primary source
MGI:MGI:1918956
See related
Ensembl:ENSMUSG00000029650 AllianceGenome:MGI:1918956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200006F02Rik
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in vacuolar transmembrane transport. Predicted to be integral component of lysosomal membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human SLC46A3 (solute carrier family 46 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 23.2), small intestine adult (RPKM 22.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G3; 5 87.58 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147812707..147831670, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147875897..147894861, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14883 Neighboring gene predicted gene, 54314 Neighboring gene STARR-positive B cell enhancer ABC_E534 Neighboring gene predicted gene, 35648 Neighboring gene proteasome maturation protein Neighboring gene STARR-seq mESC enhancer starr_14888 Neighboring gene predicted gene, 46943 Neighboring gene STARR-seq mESC enhancer starr_14889 Neighboring gene STARR-seq mESC enhancer starr_14890 Neighboring gene STARR-seq mESC enhancer starr_14891 Neighboring gene microtubule associated tumor suppressor candidate 2 Neighboring gene STARR-seq mESC enhancer starr_14892 Neighboring gene STARR-seq mESC enhancer starr_14893 Neighboring gene predicted gene, 46928

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis. Kim JH, et al. Nat Commun, 2021 Jan 12. PMID 33436590, Free PMC Article
  2. Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity. Bharadwaj R, et al. Immunity, 2023 May 9. PMID 37116499,
  3. Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice. O'Leary J, et al. PLoS One, 2011. PMID 21909369, Free PMC Article
  4. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis.
    Title: Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables copper ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to 2,3,7,8-tetrachlorodibenzodioxine IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within copper ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357002.1 → NP_001343931.1  lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC122299, AC133954
    Consensus CDS
    CCDS19880.1
    UniProtKB/Swiss-Prot
    Q9DC26
    Related
    ENSMUSP00000113879.2, ENSMUST00000118527.8
    Conserved Domains (1) summary
    cl28910
    Location:3 → 437
    MFS; Major Facilitator Superfamily

  2. NM_027872.4 → NP_082148.1  lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 precursor

    See identical proteins and their annotated locations for NP_082148.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC122299, AC133954
    Consensus CDS
    CCDS19880.1
    UniProtKB/Swiss-Prot
    Q9DC26
    Related
    ENSMUSP00000031655.4, ENSMUST00000031655.4
    Conserved Domains (1) summary
    cl28910
    Location:3 → 437
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    147812707..147831670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504867.5 → XP_006504930.1  lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 isoform X2

    See identical proteins and their annotated locations for XP_006504930.1

    UniProtKB/Swiss-Prot
    Q9DC26
    Conserved Domains (1) summary
    cl28910
    Location:3 → 437
    MFS; Major Facilitator Superfamily

  2. XM_006504865.4 → XP_006504928.1  lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 isoform X1

    See identical proteins and their annotated locations for XP_006504928.1

    UniProtKB/Swiss-Prot
    Q9DC26
    Conserved Domains (1) summary
    cl28910
    Location:3 → 437
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DC26.1 GenPept UniProtKB/Swiss-Prot:Q9DC26

Gene LinkOut

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