Colec11 collectin sub-family member 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Colec11provided by MGI
Official Full Name: collectin sub-family member 11provided by MGI
Primary source: MGI:MGI:1918943
See related: Ensembl:ENSMUSG00000036655 AllianceGenome:MGI:1918943
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CL-K1
Summary: This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in the human gene are a cause of 3MC syndrome-2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression: Biased expression in liver adult (RPKM 12.7), liver E18 (RPKM 9.2) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A2; 12 10.98 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (28644171..28673458, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (28594172..28623458, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Collectin-11 promotes cancer cell proliferation and tumor growth.
Title: Collectin-11 promotes cancer cell proliferation and tumor growth.
Role of collectin-11 in innate defence against uropathogenic Escherichia coli infection.
Title: Role of collectin-11 in innate defence against uropathogenic Escherichia coli infection.
Our findings demonstrate a pathogenic role for collectin-11 in the development of tubulointerstitial fibrosis and suggest that local collectin-11 promotes this fibrosis through effects on leukocyte chemotaxis and renal fibroblast proliferation.
Title: Collectin-11 Promotes the Development of Renal Tubulointerstitial Fibrosis.
this study demonstrates the role of CL-11 and the molecular mechanisms involved in modulating retinal pigment epithelial cell phagocytosis and cytokine production
Title: Collectin-11 Is an Important Modulator of Retinal Pigment Epithelial Cell Phagocytosis and Cytokine Production.
CL-K1-/- mice revealed decreased phagocytosis of Streptococcus pneumoniae
Title: Collectin Kidney 1 Plays an Important Role in Innate Immunity against Streptococcus pneumoniae Infection.
intrarenal expression of COLEC11 rapidly increases in the postischemic period and colocalizes with complement deposited along the basolateral surface of the proximal renal tubule in association with L-fucose, the potential binding ligand for COLEC11.
Title: Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury.
identify collectin CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK
Title: Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis.
This profile of CL-K1 expression is unique among the collectins. [CL-K1]
Title: Immunolocalization of a novel collectin CL-K1 in murine tissues.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables fucose binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mannose binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oligosaccharide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral response	ISO Inferred from Sequence Orthology more info
involved_in complement activation	ISO Inferred from Sequence Orthology more info
involved_in complement activation, lectin pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of opsonization	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: collectin-11

Names: collectin kidney protein 1; collectin-L2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313978.2 → NP_001300907.1 collectin-11 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC165283

Consensus CDS

CCDS88320.1

UniProtKB/Swiss-Prot

Q3SXB7, Q3SXB8, Q9DC75

UniProtKB/TrEMBL

A0A1Y7VKG6

Related

ENSMUSP00000152876.2, ENSMUST00000220836.2

Conserved Domains (2) summary

cd03591
Location:158 → 273

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:41 → 96

Collagen; Collagen triple helix repeat (20 copies)
NM_027866.3 → NP_082142.1 collectin-11 isoform 2 precursor

See identical proteins and their annotated locations for NP_082142.1

Status: REVIEWED

Source sequence(s)

AC165283

Consensus CDS

CCDS36426.1

UniProtKB/Swiss-Prot

Q3SXB7, Q3SXB8, Q9DC75

UniProtKB/TrEMBL

A0A0R4J0M6

Related

ENSMUSP00000049285.8, ENSMUST00000036136.9

Conserved Domains (2) summary

cd03591
Location:152 → 267

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:48 → 99

Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

28644171..28673458 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515221.3 → XP_006515284.1 collectin-11 isoform X1

See identical proteins and their annotated locations for XP_006515284.1

Conserved Domains (1) summary

cd03591
Location:88 → 203

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
XM_030246930.2 → XP_030102790.1 collectin-11 isoform X1

Conserved Domains (1) summary

cd03591
Location:88 → 203

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
XM_017315207.3 → XP_017170696.1 collectin-11 isoform X2

Conserved Domains (1) summary

pfam01391
Location:41 → 96

Collagen; Collagen triple helix repeat (20 copies)