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Gypc glycophorin C [ Mus musculus (house mouse) ]

Gene ID: 71683, updated on 5-Mar-2024

Summary

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Official Symbol
Gypcprovided by MGI
Official Full Name
glycophorin Cprovided by MGI
Primary source
MGI:MGI:1098566
See related
Ensembl:ENSMUSG00000090523 AllianceGenome:MGI:1098566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd236r; 0610037F22Rik
Summary
Located in cortical cytoskeleton and membrane. Is expressed in brain; brain ventricular layer; liver lobe; and pancreas mesenchyme. Human ortholog(s) of this gene implicated in malaria. Orthologous to human GYPC (glycophorin C (Gerbich blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 29.8), liver E14 (RPKM 27.7) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B1; 18 18.05 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32661373..32693087, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32528320..32560034, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 20136 Neighboring gene predicted gene 44577 Neighboring gene VISTA enhancer mm291 Neighboring gene STARR-positive B cell enhancer ABC_E4241 Neighboring gene predicted gene, 35480 Neighboring gene predicted gene, 25826

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Stem Cell Strategy Identifies Glycophorin C as a Major Erythrocyte Receptor for the Rodent Malaria Parasite Plasmodium berghei. Yiangou L, et al. PLoS One, 2016. PMID 27362409, Free PMC Article
  2. Cloning and expression of a murine histone deacetylase 3 (mHdac3) cDNA and mapping to a region of conserved synteny between murine chromosome 18 and human chromosome 5. Dangond F, et al. Mol Cell Biol Res Commun, 1999 Aug. PMID 10542131
  3. Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating. Huang YS, et al. Sci Rep, 2017 Jul 12. PMID 28701737, Free PMC Article
  4. Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice. Robledo RF, et al. Blood, 2008 Nov 15. PMID 18723693, Free PMC Article
  5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in cortical cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cortical cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycophorin-C
Names
Gerbich antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048207.1 → NP_001041672.1  glycophorin-C isoform 1

    See identical proteins and their annotated locations for NP_001041672.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK002769, AY234183
    Consensus CDS
    CCDS57118.1
    UniProtKB/Swiss-Prot
    Q6XFR5, Q78HU7
    Related
    ENSMUSP00000134317.2, ENSMUST00000174459.2
    Conserved Domains (1) summary
    smart00294
    Location:47 → 65
    4.1m; putative band 4.1 homologues' binding motif

  2. NM_001347610.1 → NP_001334539.1  glycophorin-C isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter tha isoform 1.
    Source sequence(s)
    AC098881, AK002769, BB842332, BE951636
    Consensus CDS
    CCDS84368.1
    UniProtKB/TrEMBL
    F7D1I5, G3UXY6
    Related
    ENSMUSP00000133874.2, ENSMUST00000174000.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    32661373..32693087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027863.2: Suppressed sequence

    Description
    NM_027863.2: This RefSeq was permanently suppressed because the coding region was annotated in the wrong location, therefore, representing the wrong protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78HU7.2 GenPept UniProtKB/Swiss-Prot:Q78HU7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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