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Acy3 aminoacylase 3 [ Mus musculus (house mouse) ]

Gene ID: 71670, updated on 5-Mar-2024

Summary

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Official Symbol
Acy3provided by MGI
Official Full Name
aminoacylase 3provided by MGI
Primary source
MGI:MGI:1918920
See related
Ensembl:ENSMUSG00000024866 AllianceGenome:MGI:1918920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AA3; AAIII; Acy-3; HCBP1; 0610006H10Rik
Summary
This gene encodes a member of the aminoacylase family of enzymes. This enzyme specifically deacetylates N-acetyl aromatic amino acids and mercapturic acids. Action of this enzyme on metabolites of the environmental contaminant trichloroethylene leads to the generation of toxic products that may lead to kidney failure. This protein has been found to bind to the hepatitis C virus core protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Biased expression in kidney adult (RPKM 558.9), liver adult (RPKM 83.7) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Acy3 in Genome Data Viewer
Location:
19 A; 19 3.7 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4036570..4040007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3986570..3990007)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 3 family, member B3 Neighboring gene aldehyde dehydrogenase 3 family, member B2 Neighboring gene STARR-positive B cell enhancer ABC_E7625 Neighboring gene predicted gene, 52386 Neighboring gene T-box 10 Neighboring gene nudix hydrolase 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse aminoacylase 3: a metalloenzyme activated by cobalt and nickel. Tsirulnikov K, et al. Biochim Biophys Acta, 2009 Jul. PMID 19362172, Free PMC Article
  2. Specificity of aminoacylase III-mediated deacetylation of mercapturic acids. Newman D, et al. Drug Metab Dispos, 2007 Jan. PMID 17012540
  3. Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein. Tsirulnikov K, et al. FEBS Lett, 2012 Nov 2. PMID 23010594, Free PMC Article
  4. Structures of aminoacylase 3 in complex with acetylated substrates. Hsieh JM, et al. Proc Natl Acad Sci U S A, 2010 Oct 19. PMID 20921362, Free PMC Article
  5. Structural characterization of dimeric murine aminoacylase III. Ryazantsev S, et al. FEBS Lett, 2007 May 1. PMID 17434493

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus that may by implicated in HCV pathogenesis.
    Title: Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein.
  2. structures, in conjunction with biochemical data, indicated that AA3 mediates substrate specificity through van der Waals interactions providing a dynamic interaction interface, which facilitates a diverse range of substrates
    Title: Structures of aminoacylase 3 in complex with acetylated substrates.
  3. A 16A resolution model of the AAIII dimer.
    Title: Structural characterization of dimeric murine aminoacylase III.
  4. data suggest that in kidney proximal tubules, aminoacylase III plays an important role in deacetylating mercapturic acids
    Title: Structural characterization, tissue distribution, and functional expression of murine aminoacylase III.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminoacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
Names
acylase III
aminoacylase III
aspartoacylase (aminoacylase) 3
aspartoacylase-2
hepatitis C virus core-binding protein 1
NP_001289408.1
NP_001289409.1
NP_001289410.1
NP_001289411.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302479.1 → NP_001289408.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 1

    See identical proteins and their annotated locations for NP_001289408.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AA110692, AK143782
    Consensus CDS
    CCDS29406.1
    UniProtKB/Swiss-Prot
    Q3UP59, Q91XE4, Q9DD17
    Related
    ENSMUSP00000158512.2, ENSMUST00000236510.2
    Conserved Domains (2) summary
    cd06909
    Location:13 → 299
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:10 → 299
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

  2. NM_001302480.1 → NP_001289409.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 1

    See identical proteins and their annotated locations for NP_001289409.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AA110692, AK143782
    Consensus CDS
    CCDS29406.1
    UniProtKB/Swiss-Prot
    Q3UP59, Q91XE4, Q9DD17
    Conserved Domains (2) summary
    cd06909
    Location:13 → 299
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:10 → 299
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

  3. NM_001302481.1 → NP_001289410.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 1

    See identical proteins and their annotated locations for NP_001289410.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AA110692, AK143782
    Consensus CDS
    CCDS29406.1
    UniProtKB/Swiss-Prot
    Q3UP59, Q91XE4, Q9DD17
    Related
    ENSMUSP00000158093.2, ENSMUST00000235612.2
    Conserved Domains (2) summary
    cd06909
    Location:13 → 299
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:10 → 299
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

  4. NM_001302482.1 → NP_001289411.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in both UTRs and lacks an alternate exon in the 5' coding region compared to variant 1, resulting in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA110692, AK143782
    UniProtKB/Swiss-Prot
    Q91XE4
    Conserved Domains (1) summary
    cl11393
    Location:13 → 79
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4036570..4040007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027857.3: Suppressed sequence

    Description
    NM_027857.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XE4.1 GenPept UniProtKB/Swiss-Prot:Q91XE4

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