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Fuca1 fucosidase, alpha-L- 1, tissue [ Mus musculus (house mouse) ]

Gene ID: 71665, updated on 21-Apr-2024

Summary

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Official Symbol
Fuca1provided by MGI
Official Full Name
fucosidase, alpha-L- 1, tissueprovided by MGI
Primary source
MGI:MGI:95593
See related
Ensembl:ENSMUSG00000028673 AllianceGenome:MGI:95593
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Afuc; Fuca; 0610006A03Rik; 9530055J05Rik
Summary
Predicted to enable alpha-L-fucosidase activity and carbohydrate binding activity. Predicted to be involved in fucose metabolic process and glycoside catabolic process. Predicted to be active in lysosome. Is expressed in several structures, including alimentary system; brain; cranium; genitourinary system; and heart. Used to study fucosidosis. Human ortholog(s) of this gene implicated in fucosidosis. Orthologous to human FUCA1 (alpha-L-fucosidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 71.1), kidney adult (RPKM 50.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 68.01 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135648037..135667611)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135920726..135940300)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4683 Neighboring gene STARR-positive B cell enhancer ABC_E1660 Neighboring gene proline-rich nuclear receptor coactivator 2 Neighboring gene STARR-seq mESC enhancer starr_11738 Neighboring gene STARR-positive B cell enhancer ABC_E8000 Neighboring gene STARR-positive B cell enhancer ABC_E4684 Neighboring gene cannabinoid receptor 2 Neighboring gene STARR-seq mESC enhancer starr_11739 Neighboring gene STARR-positive B cell enhancer ABC_E4685 Neighboring gene STARR-positive B cell enhancer ABC_E4686 Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A lyase Neighboring gene STARR-positive B cell enhancer ABC_E3529 Neighboring gene galactose-4-epimerase, UDP

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sensorimotor and Neurocognitive Dysfunctions Parallel Early Telencephalic Neuropathology in Fucosidosis Mice. Stroobants S, et al. Front Behav Neurosci, 2018. PMID 29706874, Free PMC Article
  2. A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease. Wolf H, et al. Dis Model Mech, 2016 Sep 1. PMID 27491075, Free PMC Article
  3. Distribution, crypticity, stability, and localization of α-L-fucosidase of mouse cauda epididymal sperm. Phopin K, et al. Mol Reprod Dev, 2012 Mar. PMID 22231989
  4. Variation in alpha-L-fucosidase properties among 28 inbred mouse strains: six strains have high enzyme activity and heat-stabile enzyme with a variant pH-activity curve; twenty-two strains have low activity and heat-labile enzyme. Johnson WG, et al. Biochem Genet, 1986 Jun. PMID 3741369
  5. Strain variation in spermatozoal glycosidases in inbred mice. Self SJ, et al. Genet Res, 1978 Oct. PMID 744483

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-L-fucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-L-fucosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
  
enables fucosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoside catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tissue alpha-L-fucosidase
Names
alpha-L-fucosidase 1
alpha-L-fucosidase I
alpha-L-fucoside fucohydrolase 1
NP_077205.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024243.4 → NP_077205.3  tissue alpha-L-fucosidase precursor

    See identical proteins and their annotated locations for NP_077205.3

    Status: VALIDATED

    Source sequence(s)
    AK089958, AK151361, AL672076, BY158254
    Consensus CDS
    CCDS18794.1
    UniProtKB/Swiss-Prot
    B1AV51, Q3UAH8, Q8BN13, Q99LJ1, Q9DD22
    UniProtKB/TrEMBL
    Q3TCW3
    Related
    ENSMUSP00000030434.5, ENSMUST00000030434.5
    Conserved Domains (3) summary
    smart00812
    Location:20 → 399
    Alpha_L_fucos; Alpha-L-fucosidase
    COG3669
    Location:49 → 367
    AfuC; Alpha-L-fucosidase [Carbohydrate transport and metabolism]
    pfam16757
    Location:372 → 449
    Fucosidase_C; Alpha-L-fucosidase C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135648037..135667611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LJ1.1 GenPept UniProtKB/Swiss-Prot:Q99LJ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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