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Zgrf1 zinc finger, GRF-type containing 1 [ Mus musculus (house mouse) ]

Gene ID: 71643, updated on 11-Apr-2024

Summary

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Official Symbol
Zgrf1provided by MGI
Official Full Name
zinc finger, GRF-type containing 1provided by MGI
Primary source
MGI:MGI:1918893
See related
Ensembl:ENSMUSG00000051278 AllianceGenome:MGI:1918893
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930422G04Rik
Summary
Predicted to enable 5'-flap endonuclease activity and RNA binding activity. Predicted to be involved in replication fork reversal. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Is expressed in brain ventricular layer and nose. Orthologous to human ZGRF1 (zinc finger GRF-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 4.0), limb E14.5 (RPKM 2.2) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 G2; 3 56.54 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (127347080..127411672)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (127553396..127618023)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene La ribonucleoprotein 7, transcriptional regulator Neighboring gene predicted gene, 51018 Neighboring gene microRNA 302d Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:127256185-127256372 Neighboring gene microRNA 367 Neighboring gene STARR-seq mESC enhancer starr_08956 Neighboring gene predicted gene, 40147 Neighboring gene neurogenin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-3' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in recombinational repair ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
5'-3' DNA helicase ZGRF1
Names
GRF-type zinc finger domain-containing protein 1
protein ZGRF1
NP_932114.2
XP_006502172.1
XP_011238535.1
XP_017175214.1
XP_017175215.1
XP_017175216.1
XP_030108684.1
XP_030108685.1
XP_036019224.1
XP_036019225.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_197997.2 → NP_932114.2  5'-3' DNA helicase ZGRF1

    See identical proteins and their annotated locations for NP_932114.2

    Status: VALIDATED

    Source sequence(s)
    AK046429, BC079891, CO044435
    Consensus CDS
    CCDS51066.1
    UniProtKB/Swiss-Prot
    E9Q2K6, Q0VGT4
    UniProtKB/TrEMBL
    I3PQW4
    Related
    ENSMUSP00000044432.5, ENSMUST00000043108.9
    Conserved Domains (5) summary
    COG1112
    Location:1487 → 1837
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam06839
    Location:1109 → 1153
    zf-GRF; GRF zinc finger
    pfam10382
    Location:3 → 72
    DUF2439; Protein of unknown function (DUF2439)
    pfam13086
    Location:1376 → 1605
    AAA_11; AAA domain
    pfam13087
    Location:1616 → 1800
    AAA_12; AAA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    127347080..127411672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319725.3 → XP_017175214.1  5'-3' DNA helicase ZGRF1 isoform X1

    UniProtKB/TrEMBL
    I3PQW4
    Conserved Domains (4) summary
    TIGR00376
    Location:1568 → 2003
    TIGR00376; DNA helicase, putative
    pfam06839
    Location:1267 → 1311
    zf-GRF; GRF zinc finger
    pfam10382
    Location:3 → 75
    DUF2439; Protein of unknown function (DUF2439)
    pfam13087
    Location:1774 → 1981
    AAA_12; AAA domain

  2. XM_017319726.3 → XP_017175215.1  5'-3' DNA helicase ZGRF1 isoform X3

    UniProtKB/TrEMBL
    I3PQW4
    Conserved Domains (4) summary
    TIGR00376
    Location:1410 → 1845
    TIGR00376; DNA helicase, putative
    pfam06839
    Location:1109 → 1153
    zf-GRF; GRF zinc finger
    pfam10382
    Location:3 → 75
    DUF2439; Protein of unknown function (DUF2439)
    pfam13087
    Location:1616 → 1823
    AAA_12; AAA domain

  3. XM_030252824.2 → XP_030108684.1  5'-3' DNA helicase ZGRF1 isoform X6

    Conserved Domains (3) summary
    TIGR00376
    Location:542 → 977
    TIGR00376; DNA helicase, putative
    pfam06839
    Location:241 → 285
    zf-GRF; GRF zinc finger
    pfam13087
    Location:748 → 955
    AAA_12; AAA domain

  4. XM_006502109.5 → XP_006502172.1  5'-3' DNA helicase ZGRF1 isoform X2

    UniProtKB/TrEMBL
    I3PQW4
    Conserved Domains (4) summary
    TIGR00376
    Location:1568 → 1980
    TIGR00376; DNA helicase, putative
    pfam06839
    Location:1267 → 1311
    zf-GRF; GRF zinc finger
    pfam10382
    Location:3 → 75
    DUF2439; Protein of unknown function (DUF2439)
    pfam13087
    Location:1774 → 1958
    AAA_12; AAA domain

  5. XM_011240233.4 → XP_011238535.1  5'-3' DNA helicase ZGRF1 isoform X4

    Conserved Domains (1) summary
    pfam10382
    Location:3 → 75
    DUF2439; Protein of unknown function (DUF2439)

  6. XM_030252825.2 → XP_030108685.1  5'-3' DNA helicase ZGRF1 isoform X6

    Conserved Domains (3) summary
    TIGR00376
    Location:542 → 977
    TIGR00376; DNA helicase, putative
    pfam06839
    Location:241 → 285
    zf-GRF; GRF zinc finger
    pfam13087
    Location:748 → 955
    AAA_12; AAA domain

  7. XM_017319727.3 → XP_017175216.1  5'-3' DNA helicase ZGRF1 isoform X5

    Conserved Domains (3) summary
    TIGR00376
    Location:694 → 1129
    TIGR00376; DNA helicase, putative
    pfam06839
    Location:393 → 437
    zf-GRF; GRF zinc finger
    pfam13087
    Location:900 → 1107
    AAA_12; AAA domain

  8. XM_036163332.1 → XP_036019225.1  5'-3' DNA helicase ZGRF1 isoform X8

    Conserved Domains (3) summary
    pfam06839
    Location:9 → 53
    zf-GRF; GRF zinc finger
    pfam13087
    Location:516 → 700
    AAA_12; AAA domain
    cl28899
    Location:275 → 539
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  9. XM_036163331.1 → XP_036019224.1  5'-3' DNA helicase ZGRF1 isoform X7

    Conserved Domains (3) summary
    pfam06839
    Location:9 → 53
    zf-GRF; GRF zinc finger
    pfam13087
    Location:516 → 723
    AAA_12; AAA domain
    cl28899
    Location:275 → 525
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RNA

  1. XR_867232.3 RNA Sequence

    Related
    ENSMUST00000200490.5

  2. XR_004941395.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VGT4.2 GenPept UniProtKB/Swiss-Prot:Q0VGT4

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