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Armh3 armadillo-like helical domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 71617, updated on 21-Apr-2024

Summary

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Official Symbol
Armh3provided by MGI
Official Full Name
armadillo-like helical domain containing 3provided by MGI
Primary source
MGI:MGI:1918867
See related
Ensembl:ENSMUSG00000039901 AllianceGenome:MGI:1918867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130011E15Rik
Summary
Predicted to be involved in regulation of Golgi organization. Predicted to be located in Golgi membrane. Predicted to be active in cytosol. Is expressed in heart. Orthologous to human ARMH3 (armadillo like helical domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 5.9), whole brain E14.5 (RPKM 5.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 38.75 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45805799..45987071, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45817362..45998632, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4286 Neighboring gene O-GlcNAcase Neighboring gene STARR-seq mESC enhancer starr_46285 Neighboring gene Kv channel-interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_46286 Neighboring gene STARR-positive B cell enhancer ABC_E7665 Neighboring gene STARR-seq mESC enhancer starr_46288 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46291 Neighboring gene RIKEN cDNA 4930505N22 gene Neighboring gene STARR-positive B cell enhancer ABC_E4287 Neighboring gene HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene STARR-seq mESC enhancer starr_46294 Neighboring gene STARR-positive B cell enhancer ABC_E5707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46114769-46114954 Neighboring gene LIM domain binding 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING. Fang R, et al. Immunity, 2023 Mar 14. PMID 36921576
  2. Armadillo-like helical domain containing-4 is dynamically expressed in both the first and second heart fields. Conway SJ, et al. Gene Expr Patterns, 2019 Dec. PMID 31655130, Free PMC Article
  3. TRF2-mediated telomere protection is dispensable in pluripotent stem cells. Markiewicz-Potoczny M, et al. Nature, 2021 Jan. PMID 33239785, Free PMC Article
  4. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
  5. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.
    Title: ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of Golgi organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
armadillo-like helical domain-containing protein 3
Names
UPF0668 protein C10orf76 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198296.2 → NP_938038.2  armadillo-like helical domain-containing protein 3

    See identical proteins and their annotated locations for NP_938038.2

    Status: VALIDATED

    Source sequence(s)
    AK159765, BC058989
    Consensus CDS
    CCDS50454.1
    UniProtKB/Swiss-Prot
    Q3TWB1, Q6PD19, Q80V50
    Related
    ENSMUSP00000048454.8, ENSMUST00000045396.9
    Conserved Domains (1) summary
    pfam08427
    Location:441 → 669
    DUF1741; Domain of unknown function (DUF1741)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    45805799..45987071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161692.1 → XP_036017585.1  armadillo-like helical domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    pfam08427
    Location:441 → 642
    DUF1741; Domain of unknown function (DUF1741)

  2. XM_011247345.3 → XP_011245647.1  armadillo-like helical domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011245647.1

    UniProtKB/Swiss-Prot
    Q3TWB1, Q6PD19, Q80V50
    Conserved Domains (1) summary
    pfam08427
    Location:441 → 669
    DUF1741; Domain of unknown function (DUF1741)

  3. XM_036161693.1 → XP_036017586.1  armadillo-like helical domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    pfam08427
    Location:441 → 642
    DUF1741; Domain of unknown function (DUF1741)

  4. XM_006527344.5 → XP_006527407.1  armadillo-like helical domain-containing protein 3 isoform X3

    Conserved Domains (1) summary
    pfam08427
    Location:441 → 594
    DUF1741; Domain of unknown function (DUF1741)

RNA

  1. XR_386511.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PD19.2 GenPept UniProtKB/Swiss-Prot:Q6PD19

Gene LinkOut

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