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Senp8 SUMO peptidase family member, NEDD8 specific [ Mus musculus (house mouse) ]

Gene ID: 71599, updated on 5-Mar-2024

Summary

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Official Symbol
Senp8provided by MGI
Official Full Name
SUMO peptidase family member, NEDD8 specificprovided by MGI
Primary source
MGI:MGI:1918849
See related
Ensembl:ENSMUSG00000051705 AllianceGenome:MGI:1918849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Den1; Nedp1; Prsc2; 9130010J17Rik
Summary
Predicted to enable NEDD8-specific protease activity. Predicted to be involved in protein desumoylation. Predicted to be active in nucleus. Is expressed in testis. Orthologous to human SENP8 (SUMO peptidase family member, NEDD8 specific). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 2.5), placenta adult (RPKM 1.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 32.11 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (59641542..59657932, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (59734259..59750649, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115487221 Neighboring gene pyruvate kinase, muscle Neighboring gene GRAM domain containing 2A Neighboring gene STARR-positive B cell enhancer mm9_chr9:59570886-59571186 Neighboring gene STARR-positive B cell enhancer mm9_chr9:59598396-59598697 Neighboring gene transcription factor BTF3-like Neighboring gene myosin IXa Neighboring gene predicted gene, 20275 Neighboring gene 60S ribosomal protein L37 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of DEN1, a deneddylase of the ULP family. Gan-Erdene T, et al. J Biol Chem, 2003 Aug 1. PMID 12759362
  2. Neddylation of PTEN regulates its nuclear import and promotes tumor development. Xie P, et al. Cell Res, 2021 Mar. PMID 33299139, Free PMC Article
  3. Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. Woolf E, et al. Proc Natl Acad Sci U S A, 2003 Jun 24. PMID 12796513, Free PMC Article
  4. DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. Wu K, et al. J Biol Chem, 2003 Aug 1. PMID 12759363
  5. NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. Mendoza HM, et al. J Biol Chem, 2003 Jul 11. PMID 12730221

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables deNEDDylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deNEDDylase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein deneddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sentrin-specific protease 8
Names
NEDD8-specific protease 1
SUMO/sentrin specific peptidase 8
SUMO/sentrin specific protease 8
SUMO/sentrin specific protease family member 8
deneddylase-1
protease, cysteine, 2 (NEDD8 specific)
sentrin/SUMO-specific protease SENP8
NP_001165539.1
NP_001165540.1
NP_001165541.1
NP_001165542.1
NP_082114.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172068.1 → NP_001165539.1  sentrin-specific protease 8 isoform a

    See identical proteins and their annotated locations for NP_001165539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b).
    Source sequence(s)
    AK018606, AK029856, AK049120, BB522944, DV645349
    Consensus CDS
    CCDS23254.1
    UniProtKB/Swiss-Prot
    Q543P0, Q9D2Z4
    UniProtKB/TrEMBL
    Q3UWN3
    Related
    ENSMUSP00000150601.2, ENSMUST00000217093.2
    Conserved Domains (1) summary
    cl23802
    Location:26 → 188
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  2. NM_001172069.1 → NP_001165540.1  sentrin-specific protease 8 isoform a

    See identical proteins and their annotated locations for NP_001165540.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b).
    Source sequence(s)
    AK029856, BB522944, CO431667, DV645349
    Consensus CDS
    CCDS23254.1
    UniProtKB/Swiss-Prot
    Q543P0, Q9D2Z4
    UniProtKB/TrEMBL
    Q3UWN3
    Related
    ENSMUSP00000150192.2, ENSMUST00000213257.2
    Conserved Domains (1) summary
    cl23802
    Location:26 → 188
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  3. NM_001172070.1 → NP_001165541.1  sentrin-specific protease 8 isoform a

    See identical proteins and their annotated locations for NP_001165541.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b).
    Source sequence(s)
    AK029856, AK136214, BB522944, DV645349
    Consensus CDS
    CCDS23254.1
    UniProtKB/Swiss-Prot
    Q543P0, Q9D2Z4
    UniProtKB/TrEMBL
    Q3UWN3
    Related
    ENSMUSP00000129441.3, ENSMUST00000163586.9
    Conserved Domains (1) summary
    cl23802
    Location:26 → 188
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  4. NM_001172071.1 → NP_001165542.1  sentrin-specific protease 8 isoform b

    See identical proteins and their annotated locations for NP_001165542.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and includes an uses an start codon, compared to variant 1. The resulting isoform (b) has a longer N-terminus, compared to isoform a.
    Source sequence(s)
    AK018606, AK029856, BB522944, DV645349
    Consensus CDS
    CCDS52819.1
    UniProtKB/TrEMBL
    A0A1L1SRH8, Q3UWN3
    Related
    ENSMUSP00000149463.2, ENSMUST00000216329.2
    Conserved Domains (1) summary
    cl23802
    Location:39 → 201
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  5. NM_027838.3 → NP_082114.1  sentrin-specific protease 8 isoform a

    See identical proteins and their annotated locations for NP_082114.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b).
    Source sequence(s)
    AK029856, BB522944, DV645349
    Consensus CDS
    CCDS23254.1
    UniProtKB/Swiss-Prot
    Q543P0, Q9D2Z4
    UniProtKB/TrEMBL
    Q3UWN3
    Related
    ENSMUSP00000054509.5, ENSMUST00000051039.5
    Conserved Domains (1) summary
    cl23802
    Location:26 → 188
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    59641542..59657932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2Z4.2 GenPept UniProtKB/Swiss-Prot:Q9D2Z4

Gene LinkOut

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