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Zfp251 zinc finger protein 251 [ Mus musculus (house mouse) ]

Gene ID: 71591, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp251provided by MGI
Official Full Name
zinc finger protein 251provided by MGI
Primary source
MGI:MGI:1918841
See related
Ensembl:ENSMUSG00000022526 AllianceGenome:MGI:1918841
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130001M19Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be active in nucleus. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Orthologous to human ZNF251 (zinc finger protein 251). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 8.2), whole brain E14.5 (RPKM 7.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 36.28 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76736331..76755635, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76852131..76871435, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 39 Neighboring gene predicted gene, 17271 Neighboring gene STARR-positive B cell enhancer ABC_E8939 Neighboring gene STARR-seq mESC enhancer starr_39062 Neighboring gene predicted gene, 41350 Neighboring gene STARR-positive B cell enhancer ABC_E11593 Neighboring gene STARR-positive B cell enhancer ABC_E2442 Neighboring gene zinc finger protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E5492 Neighboring gene COMM domain containing 5 Neighboring gene ribosomal protein L8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zinc finger protein 251 deficiency impairs glucose metabolism by inducing adipocyte hypertrophy. Kim E, et al. Mol Cell Endocrinol, 2023 Feb 15. PMID 36565788
  2. Functional screen identifies regulators of murine hematopoietic stem cell repopulation. Holmfeldt P, et al. J Exp Med, 2016 Mar 7. PMID 26880577, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zinc finger protein 251 deficiency impairs glucose metabolism by inducing adipocyte hypertrophy.
    Title: Zinc finger protein 251 deficiency impairs glucose metabolism by inducing adipocyte hypertrophy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC69913

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 251

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007568.2 → NP_001007569.1  zinc finger protein 251

    See identical proteins and their annotated locations for NP_001007569.1

    Status: PROVISIONAL

    Source sequence(s)
    AC157554
    Consensus CDS
    CCDS27593.1
    UniProtKB/TrEMBL
    Q3USU9, Q6PCX8
    Related
    ENSMUSP00000079268.6, ENSMUST00000080406.7
    Conserved Domains (6) summary
    smart00349
    Location:15 → 75
    KRAB; krueppel associated box
    COG5048
    Location:228 → 509
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288 → 308
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:202 → 224
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:15 → 54
    KRAB; KRAB box
    pfam13465
    Location:356 → 381
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76736331..76755635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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