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Mcm9 minichromosome maintenance 9 homologous recombination repair factor [ Mus musculus (house mouse) ]

Gene ID: 71567, updated on 21-Apr-2024

Summary

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Official Symbol
Mcm9provided by MGI
Official Full Name
minichromosome maintenance 9 homologous recombination repair factorprovided by MGI
Primary source
MGI:MGI:1918817
See related
Ensembl:ENSMUSG00000058298 AllianceGenome:MGI:1918817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm235; Mcmdc1; 9030408O17Rik
Summary
Enables chromatin binding activity. Involved in DNA repair and female gamete generation. Part of MCM8-MCM9 complex. Is expressed in several structures, including genitourinary system; liver; neural retina; spleen; and telencephalon. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in ovarian dysgenesis 4. Orthologous to human MCM9 (minichromosome maintenance 9 homologous recombination repair factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.4), liver E14 (RPKM 2.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B3; 10 27.21 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (53412411..53507251, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (53536315..53630006, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 229B, pseudogene Neighboring gene STARR-seq mESC enhancer starr_26695 Neighboring gene STARR-seq mESC enhancer starr_26696 Neighboring gene STARR-seq mESC enhancer starr_26698 Neighboring gene predicted gene, 40650 Neighboring gene predicted gene, 20597 Neighboring gene STARR-seq mESC enhancer starr_26699 Neighboring gene STARR-positive B cell enhancer ABC_E6844 Neighboring gene STARR-positive B cell enhancer ABC_E10606 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:53349966-53350075 Neighboring gene anti-silencing function 1A histone chaperone Neighboring gene family with sequence similarity 184, member A Neighboring gene mannosidase 1, alpha Neighboring gene STARR-positive B cell enhancer mm9_chr10:53704763-53705064 Neighboring gene predicted gene, 53584

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors. Lutzmann M, et al. Cell Rep, 2019 Sep 10. PMID 31509747
  2. Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family. Lutzmann M, et al. Gene, 2005 Dec 5. PMID 16226853
  3. Identification of a novel cell-cycle-induced MCM family protein MCM9. Yoshida K. Biochem Biophys Res Commun, 2005 Jun 3. PMID 15850810
  4. MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination. Lutzmann M, et al. Mol Cell, 2012 Aug 24. PMID 22771120
  5. The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery. O'Driscoll M. J Pathol, 2017 Jan. PMID 27757957

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.
    Title: MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.
  2. genetic studies of DNA damage response pathways that underlie germ cell depletion in mice mutant for minichromosome maintenance 9
    Title: MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway.
  3. MCM8 and MCM9 form a complex and that they coregulate their stability.
    Title: MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination.
  4. Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.
    Title: Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.
  5. Identified a novel MCM family gene, MCM9, by using bioinformatics; mouse MCM9 mRNA was upregulated by transcription factor E2E1 and serum stimulation in NIH3T3 cells.
    Title: Identification of a novel cell-cycle-induced MCM family protein MCM9.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC70158

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables MutLbeta complex binding ISO
Inferred from Sequence Orthology
more info
  
enables MutSalpha complex binding ISO
Inferred from Sequence Orthology
more info
  
enables MutSbeta complex binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in female gamete generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamete generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
  
involved_in recombinational interstrand cross-link repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in recombinational interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MCM8-MCM9 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MCM8-MCM9 complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA helicase MCM9
Names
DNA replication licensing factor MCM9
mini-chromosome maintenance deficient 9
mini-chromosome maintenance deficient domain-containing protein 1
minichromosome maintenance complex component 9
NP_082106.3
XP_006512919.1
XP_006512920.1
XP_011241508.1
XP_017169587.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027830.3 → NP_082106.3  DNA helicase MCM9

    Status: VALIDATED

    Source sequence(s)
    AC153949, AC155941
    Consensus CDS
    CCDS23846.2
    UniProtKB/Swiss-Prot
    Q2KHI9, Q3V370, Q6P6J6, Q9D344
    Related
    ENSMUSP00000157761.2, ENSMUST00000237608.2
    Conserved Domains (2) summary
    COG1241
    Location:10 → 605
    Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
    cl25751
    Location:739 → 1004
    DUF4045; Domain of unknown function (DUF4045)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    53412411..53507251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314098.3 → XP_017169587.1  DNA helicase MCM9 isoform X1

    Conserved Domains (2) summary
    PTZ00449
    Location:384 → 649
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl28901
    Location:30 → 248
    MCM; MCM helicase family

  2. XM_011243206.2 → XP_011241508.1  DNA helicase MCM9 isoform X2

    See identical proteins and their annotated locations for XP_011241508.1

    Conserved Domains (2) summary
    PTZ00449
    Location:365 → 630
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl28901
    Location:10 → 229
    MCM; MCM helicase family

  3. XM_006512857.5 → XP_006512920.1  DNA helicase MCM9 isoform X4

    UniProtKB/TrEMBL
    A0A1W2P804
    Related
    ENSMUSP00000151639.3, ENSMUST00000219838.3
    Conserved Domains (1) summary
    COG1241
    Location:10 → 383
    Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]

  4. XM_006512856.5 → XP_006512919.1  DNA helicase MCM9 isoform X3

    UniProtKB/TrEMBL
    A0A1W2P804
    Related
    ENSMUSP00000151893.3, ENSMUST00000218549.3
    Conserved Domains (1) summary
    COG1241
    Location:10 → 383
    Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]

RNA

  1. XR_380074.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2KHI9.2 GenPept UniProtKB/Swiss-Prot:Q2KHI9

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