Usp19 ubiquitin specific peptidase 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp19provided by MGI
Official Full Name: ubiquitin specific peptidase 19provided by MGI
Primary source: MGI:MGI:1918722
See related: Ensembl:ENSMUSG00000006676 AllianceGenome:MGI:1918722
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zmynd9; 8430421I07Rik
Summary: Enables Lys48-specific deubiquitinase activity; thiol-dependent deubiquitinase; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of proteasomal protein catabolic process; protein K48-linked deubiquitination; and protein stabilization. Located in cytosol. Is expressed in ovary and primary sex cord. Orthologous to human USP19 (ubiquitin specific peptidase 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 57.6), ovary adult (RPKM 50.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.42 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108367806..108379536)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108490607..108502337)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy.
Title: USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy.
Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway.
Title: Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway.
Usp19-/- mice produced higher levels of inflammatory cytokines and were more susceptible to TNF-alpha- and IL-1beta-triggered septicemia death compared with their wild-type littermates
Title: USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1.
USP19 is an important regulator of fat development. Its inactivation in mice exerts effects on multiple tissues, which may protect against the negative metabolic effects of high-fat feeding.
Title: The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice.
USP19 modulates GR levels and in so doing may modulate both insulin and glucocorticoid signaling, two critical pathways that control protein turnover in muscle and overall glucose homeostasis.
Title: Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling.
Data suggest that expression of Usp19 in skeletal muscle can be regulated by dietary factors; here, supplementation with phytoestrogen daidzein down-regulates Usp19 expression via Esrb signaling and increases skeletal muscle mass. (Usp19 = ubiquitin-specific peptidase 19; Esrb = estrogen receptor beta)
Title: Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor β and increases skeletal muscle mass in young female mice.
Expression of USP19 correlates with that of MuRF1 and MAFbx/atrogin-1 in skeletal muscles
Title: Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.
Deubiquitination by USP19 does modulate muscle cell differentiation and that this function requires the ER-localized isoform and appears to act through regulation of the unfolded-protein response (UPR) signaling.
Title: USP19 deubiquitinating enzyme inhibits muscle cell differentiation by suppressing unfolded-protein response signaling.
Data suggest that, in young female mice, 17beta-estradiol upregulates USP19 expression through Esr1 (estrogen receptor alpha) and leads to down-regulation of muscle mass and down-regulation of ubiquitination of muscle proteins.
Title: Female-specific regulation of skeletal muscle mass by USP19 in young mice.
E2 induces USP19 expression through nuclear ERalpha, (ii) increased USP19-mediated deubiquitinating activity represses myogenesis, and (iii) ERbeta inhibits ERalpha-activated USP19 expression.
Title: 17β-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor α.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (2)
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW211941 (e-PCR)
- UniSTS:179980

D9Dcr111 (e-PCR), detects polymorphism
- UniSTS:499013

BI274871 (e-PCR)
- UniSTS:249207

RH135846 (e-PCR)
- UniSTS:209844

NoName (e-PCR)
- UniSTS:236250

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables K48-linked deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell cycle process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 19

Names: deubiquitinating enzyme 19; ubiquitin specific protease 19; ubiquitin thioesterase 19; ubiquitin thiolesterase 19; ubiquitin-specific processing protease 19

NP_001161843.1

EC 3.4.19.12

NP_001161844.1

EC 3.4.19.12

NP_001161845.1

EC 3.4.19.12

NP_082080.3

EC 3.4.19.12

NP_663382.2

EC 3.4.19.12

XP_006511895.1

EC 3.4.19.12

XP_006511896.1

EC 3.4.19.12

XP_006511897.1

EC 3.4.19.12

XP_017169082.1

EC 3.4.19.12

XP_017169083.1

EC 3.4.19.12

XP_030100460.1

EC 3.4.19.12

XP_030100462.1

EC 3.4.19.12

XP_030100463.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168371.2 → NP_001161843.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 2

See identical proteins and their annotated locations for NP_001161843.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region and has an alternate 3' exon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AK159473, BC046824, BP762964, CJ075820

Consensus CDS

CCDS57702.1

UniProtKB/TrEMBL

A0A991ELD7, J3KMM1

Related

ENSMUSP00000135930.2, ENSMUST00000178075.8

Conserved Domains (7) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:329 → 425

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

cd02674
Location:1098 → 1255

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:541 → 727

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam01753
Location:834 → 876

zf-MYND; MYND finger

pfam14533
Location:741 → 797

USP7_C2; Ubiquitin-specific protease C-terminal

pfam16602
Location:416 → 538

USP19_linker; Linker region of USP19 deubiquitinase
NM_001168372.2 → NP_001161844.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 3

See identical proteins and their annotated locations for NP_001161844.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate 3' exon compared to variant 1. The resulting protein (isoform 3) has a distinct, shorter C-terminus compared to isoform 1.

Source sequence(s)

AK160807, BP762964, CJ075820

Consensus CDS

CCDS52924.1

UniProtKB/TrEMBL

A0A991ELD7

Related

ENSMUSP00000082119.8, ENSMUST00000085044.14

Conserved Domains (7) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:328 → 424

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

cd02674
Location:1097 → 1254

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:540 → 726

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam01753
Location:833 → 875

zf-MYND; MYND finger

pfam14533
Location:740 → 796

USP7_C2; Ubiquitin-specific protease C-terminal

pfam16602
Location:415 → 537

USP19_linker; Linker region of USP19 deubiquitinase
NM_001168373.2 → NP_001161845.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses alternate splice sites in the coding region and has an alternate 3' exon compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AK148412, BC046824, BP762964, BQ442290, BQ770257, CJ075820

Consensus CDS

CCDS81075.1

UniProtKB/TrEMBL

A0A0A6YWX1, A0A991ELD7

Related

ENSMUSP00000141738.2, ENSMUST00000193678.6

Conserved Domains (7) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:329 → 425

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

cd02674
Location:1096 → 1253

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:539 → 725

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam01753
Location:832 → 874

zf-MYND; MYND finger

pfam14533
Location:739 → 795

USP7_C2; Ubiquitin-specific protease C-terminal

pfam16602
Location:416 → 536

USP19_linker; Linker region of USP19 deubiquitinase
NM_027804.4 → NP_082080.3 ubiquitin carboxyl-terminal hydrolase 19 isoform 1

See identical proteins and their annotated locations for NP_082080.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AI644135, AK146504, CJ075820

Consensus CDS

CCDS23529.1

UniProtKB/Swiss-Prot

Q3TAC9, Q3TUE6, Q3UJD6, Q6P9T0, Q80TP5, Q80ZW5

UniProtKB/TrEMBL

A0A991ELD7

Related

ENSMUSP00000006854.8, ENSMUST00000006854.13

Conserved Domains (7) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:328 → 424

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

cd02674
Location:1097 → 1254

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:540 → 726

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam01753
Location:833 → 875

zf-MYND; MYND finger

pfam14533
Location:740 → 796

USP7_C2; Ubiquitin-specific protease C-terminal

pfam16602
Location:415 → 537

USP19_linker; Linker region of USP19 deubiquitinase
NM_145407.3 → NP_663382.2 ubiquitin carboxyl-terminal hydrolase 19 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an exon in the middle coding region and has an alternate 3' exon compared to variant 1. The resulting isoform (5) lacks an internal segment and has a different and shorter C-terminus, as compared to isoform 1.

Source sequence(s)

AK043088, BC046824, BP762964, CJ075820, CT010508

Consensus CDS

CCDS52925.1

UniProtKB/TrEMBL

A0A991ELD7, E9Q9M5

Related

ENSMUSP00000128573.3, ENSMUST00000166103.9

Conserved Domains (7) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:328 → 400

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

cd02674
Location:1073 → 1230

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:516 → 702

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam01753
Location:809 → 851

zf-MYND; MYND finger

pfam14533
Location:716 → 772

USP7_C2; Ubiquitin-specific protease C-terminal

pfam16602
Location:391 → 513

USP19_linker; Linker region of USP19 deubiquitinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

108367806..108379536

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244603.1 → XP_030100463.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X7

UniProtKB/TrEMBL

A0A991ELD7

Conserved Domains (4) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:329 → 425

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

COG5560
Location:536 → 1255

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

pfam16602
Location:416 → 538

USP19_linker; Linker region of USP19 deubiquitinase
XM_030244602.1 → XP_030100462.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X6

UniProtKB/TrEMBL

A0A991ELD7

Conserved Domains (4) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:328 → 424

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

COG5560
Location:533 → 1255

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

pfam16602
Location:415 → 535

USP19_linker; Linker region of USP19 deubiquitinase
XM_006511832.3 → XP_006511895.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X1

See identical proteins and their annotated locations for XP_006511895.1

UniProtKB/TrEMBL

A0A991ELD7

Conserved Domains (4) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:329 → 425

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

COG5560
Location:536 → 1258

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

pfam16602
Location:416 → 538

USP19_linker; Linker region of USP19 deubiquitinase
XM_006511834.2 → XP_006511897.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X4

UniProtKB/TrEMBL

A0A991ELD7

Conserved Domains (4) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:329 → 425

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

COG5560
Location:536 → 1255

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

pfam16602
Location:416 → 538

USP19_linker; Linker region of USP19 deubiquitinase
XM_006511833.2 → XP_006511896.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X2

UniProtKB/TrEMBL

A0A991ELD7

Conserved Domains (4) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:329 → 425

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

COG5560
Location:534 → 1256

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

pfam16602
Location:416 → 536

USP19_linker; Linker region of USP19 deubiquitinase
XM_017313593.2 → XP_017169082.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X5

UniProtKB/TrEMBL

A0A991ELD7

Conserved Domains (4) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:329 → 425

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

COG5560
Location:534 → 1253

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

pfam16602
Location:416 → 536

USP19_linker; Linker region of USP19 deubiquitinase
XM_030244600.2 → XP_030100460.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X3

UniProtKB/TrEMBL

A0A991ELD7

Conserved Domains (4) summary

cd06463
Location:58 → 140

p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...

cd06466
Location:328 → 424

p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...

COG5560
Location:533 → 1255

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

pfam16602
Location:415 → 535

USP19_linker; Linker region of USP19 deubiquitinase
XM_017313594.2 → XP_017169083.1 ubiquitin carboxyl-terminal hydrolase 19 isoform X8

UniProtKB/TrEMBL

A0A0A6YWN9

Related

ENSMUSP00000141628.2, ENSMUST00000194171.6

Conserved Domains (2) summary

COG5560
Location:27 → 749

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

pfam16602
Location:1 → 29

USP19_linker; Linker region of USP19 deubiquitinase