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Ptk7 PTK7 protein tyrosine kinase 7 [ Mus musculus (house mouse) ]

Gene ID: 71461, updated on 21-Apr-2024

Summary

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Official Symbol
Ptk7provided by MGI
Official Full Name
PTK7 protein tyrosine kinase 7provided by MGI
Primary source
MGI:MGI:1918711
See related
Ensembl:ENSMUSG00000023972 AllianceGenome:MGI:1918711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
chz; mPTK7/CCK4; 8430404F20Rik
Summary
Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within several processes, including animal organ development; axis elongation; and morphogenesis of an epithelium. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including alimentary system; nervous system; paraxial mesenchyme; reproductive system; and sensory organ. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 30.4), ovary adult (RPKM 29.7) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 C; 17 22.9 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46875377..46940975, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46564451..46630049, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cullin 9 Neighboring gene STARR-positive B cell enhancer ABC_E7535 Neighboring gene microRNA 6976 Neighboring gene serum response factor Neighboring gene VISTA enhancer mm1620 Neighboring gene STARR-seq mESC enhancer starr_42674 Neighboring gene STARR-seq mESC enhancer starr_42675 Neighboring gene STARR-positive B cell enhancer ABC_E10957 Neighboring gene STARR-positive B cell enhancer ABC_E7536 Neighboring gene kinesin light chain 4 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene cullin 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ptk7-Deficient Mice Have Decreased Hematopoietic Stem Cell Pools as a Result of Deregulated Proliferation and Migration. Lhoumeau AC, et al. J Immunol, 2016 May 15. PMID 27183644
  2. Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling. Yun J, et al. Nat Commun, 2023 Jan 11. PMID 36631445, Free PMC Article
  3. Protein Tyrosine Kinase 7 (PTK7) Promotes Metastasis in Hepatocellular Carcinoma via SOX9 Regulation and TGF-β Signaling. Wong TLM, et al. Cell Mol Gastroenterol Hepatol, 2023. PMID 36202326, Free PMC Article
  4. High expression of protein tyrosine kinase 7 significantly associates with invasiveness and poor prognosis in intrahepatic cholangiocarcinoma. Jin J, et al. PLoS One, 2014. PMID 24587299, Free PMC Article
  5. Cloning and characterization of the full-length mouse Ptk7 cDNA encoding a defective receptor protein tyrosine kinase. Jung JW, et al. Gene, 2004 Mar 17. PMID 15019986

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling.
    Title: Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling.
  2. Protein Tyrosine Kinase 7 (PTK7) Promotes Metastasis in Hepatocellular Carcinoma via SOX9 Regulation and TGF-beta Signaling.
    Title: Protein Tyrosine Kinase 7 (PTK7) Promotes Metastasis in Hepatocellular Carcinoma via SOX9 Regulation and TGF-β Signaling.
  3. PTK7 regulates extracellular matrix integrity and the activity levels of RAC1 and myosin II, which in turn regulates Wolffian duct morphogenesis and therefore, epididymal function.
    Title: Protein tyrosine kinase 7 regulates extracellular matrix integrity and mesenchymal intracellular RAC1 and myosin II activities during Wolffian duct morphogenesis.
  4. In a Ptk7-deficient mouse strain, loss of Ptk7 leads to a diminished pool of hematopoietic stem cells but does not affect in vitro or in vivo differentiation. This is correlated with increased quiescence and reduced homing abilities of Ptk7-deficient hematopoietic stem and progenitor cells.
    Title: Ptk7-Deficient Mice Have Decreased Hematopoietic Stem Cell Pools as a Result of Deregulated Proliferation and Migration.
  5. Data suggest that protein tyrosine kinase 7 (PTK7) is essential for Wolffian duct morphogenesis and male fertility.
    Title: Protein tyrosine kinase 7 is essential for tubular morphogenesis of the Wolffian duct.
  6. data demonstrates that PTK7 regulates the activity of KDR biphasically by inducing oligomerization of KDR molecules at lower concentrations and by surrounding KDR molecules at higher concentrations.
    Title: Biphasic effect of PTK7 on KDR activity in endothelial cells and angiogenesis.
  7. PTK7 expression plays an important role in the invasiveness of intrahepatic cholangiocarcinoma cells.
    Title: High expression of protein tyrosine kinase 7 significantly associates with invasiveness and poor prognosis in intrahepatic cholangiocarcinoma.
  8. Planar polarity of neural cell motility and intercalation requires Ptk7 function.
    Title: Distinct apical and basolateral mechanisms drive planar cell polarity-dependent convergent extension of the mouse neural plate.
  9. acts in conjunction with the noncanonical Wnt pathway to orient epithelial planar cell polarity through modulation of myosin II-based contractile tension between supporting cells and hair cells
    Title: PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium.
  10. The tyrosine kinase receptor, PTK7, is implicated in beta-catenin-dependent developmental processes.
    Title: PTK7: a cell polarity receptor with multiple facets.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables ATP binding IC
Inferred by Curator
more info
 PubMed 
NOT enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within axis elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cochlea morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within convergent extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung-associated mesenchyme development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within wound healing IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
inactive tyrosine-protein kinase 7
Names
protein chuzhoi
protein-tyrosine kinase 7
pseudo tyrosine kinase receptor 7
receptor tyrosine kinase-like protein
tyrosine-protein kinase-like 7
NP_780377.1
XP_006524985.2
XP_006524986.1
XP_006524987.1
XP_017173127.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175168.4 → NP_780377.1  inactive tyrosine-protein kinase 7 precursor

    See identical proteins and their annotated locations for NP_780377.1

    Status: VALIDATED

    Source sequence(s)
    AK053044, BC076578
    Consensus CDS
    CCDS37637.1
    UniProtKB/Swiss-Prot
    Q3V422, Q6W8S9, Q8BKG3, Q8CHK5, Q8K178
    Related
    ENSMUSP00000043703.9, ENSMUST00000044442.10
    Conserved Domains (8) summary
    cd05046
    Location:782 → 1055
    PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
    cd05760
    Location:138 → 214
    Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
    smart00219
    Location:793 → 1053
    TyrKc; Tyrosine kinase, catalytic domain
    smart00408
    Location:597 → 661
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:30 → 98
    IG; Immunoglobulin
    smart00410
    Location:590 → 673
    IG_like; Immunoglobulin like
    pfam07679
    Location:404 → 490
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:406 → 490
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46875377..46940975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524924.2 → XP_006524987.1  inactive tyrosine-protein kinase 7 isoform X3

    Conserved Domains (6) summary
    cd05046
    Location:768 → 1041
    PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
    cd05760
    Location:124 → 200
    Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
    smart00408
    Location:314 → 376
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:587 → 647
    Ig; Immunoglobulin domain
    pfam13927
    Location:205 → 280
    Ig_3; Immunoglobulin domain
    cl11960
    Location:390 → 476
    Ig; Immunoglobulin domain

  2. XM_017317638.1 → XP_017173127.1  inactive tyrosine-protein kinase 7 isoform X4

    Conserved Domains (5) summary
    cd05046
    Location:548 → 821
    PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
    smart00408
    Location:94 → 156
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:367 → 427
    Ig; Immunoglobulin domain
    pfam13927
    Location:2 → 60
    Ig_3; Immunoglobulin domain
    cl11960
    Location:170 → 256
    Ig; Immunoglobulin domain

  3. XM_006524922.2 → XP_006524985.2  inactive tyrosine-protein kinase 7 isoform X1

    Conserved Domains (6) summary
    cd05046
    Location:788 → 1061
    PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
    cd05760
    Location:144 → 220
    Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
    smart00408
    Location:334 → 396
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:607 → 667
    Ig; Immunoglobulin domain
    pfam13927
    Location:225 → 300
    Ig_3; Immunoglobulin domain
    cl11960
    Location:410 → 496
    Ig; Immunoglobulin domain

  4. XM_006524923.1 → XP_006524986.1  inactive tyrosine-protein kinase 7 isoform X2

    Conserved Domains (6) summary
    cd05046
    Location:808 → 1081
    PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
    cd05760
    Location:164 → 240
    Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
    smart00408
    Location:354 → 416
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:627 → 687
    Ig; Immunoglobulin domain
    pfam13927
    Location:245 → 320
    Ig_3; Immunoglobulin domain
    cl11960
    Location:430 → 516
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BKG3.1 GenPept UniProtKB/Swiss-Prot:Q8BKG3

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