Bcor BCL6 interacting corepressor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcorprovided by MGI
Official Full Name: BCL6 interacting corepressorprovided by MGI
Primary source: MGI:MGI:1918708
See related: Ensembl:ENSMUSG00000040363 AllianceGenome:MGI:1918708
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BcorR; mKIAA1575; 2900008C10Rik; 5830466J11Rik; 8430401K06Rik; D930024N20Rik
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and transcription corepressor activity. Acts upstream of or within blastocyst hatching and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; gonad; and lung. Human ortholog(s) of this gene implicated in colorectal cancer; stomach cancer; stomach carcinoma; syndromic microphthalmia 1; and syndromic microphthalmia 2. Orthologous to human BCOR (BCL6 corepressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 7.4), CNS E11.5 (RPKM 5.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 6.83 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (11902976..12026769, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (12036737..12160516, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity.
Title: BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity.
Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice.
Title: Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice.
Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation.
Title: Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation.
OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the Polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR.
Title: OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the Polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR.
KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis.
Title: KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis.
BCL6 corepressor (BCOR) and KDM2B, which helps target the complex to unmethylated CpG DNA islands, are required for optimal Th17 cell formation in mice after Streptococcus pyogenes infection.
Title: BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors.
Our results demonstrate that Bcor mutations collaborate with NUP98-PHF23 to induce pro-B1 acute lymphoblastic leukemia
Title: Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background.
results reveal a tumor suppressor function of BCOR in myeloid malignancies and highlight the impact of Bcor insufficiency on the initiation and progression of MDS.
Title: Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome.
This study provides mechanistic understanding of how BCOR regulates cell fate decisions and how loss of function contributes to the development of leukaemia.
Title: Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis.
Genomic characterization of Emu-Myc mouse lymphomas identifies Bcor as a Myc cooperative tumor-suppressor gene.
Title: Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation
Gene trapped (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bcor (e-PCR), detects polymorphism
- UniSTS:502717

Bcor (e-PCR), detects polymorphism
- UniSTS:502718

Bcor (e-PCR), detects polymorphism
- UniSTS:502719

Bcor (e-PCR), detects polymorphism
- UniSTS:502720

Bcor (e-PCR), detects polymorphism
- UniSTS:502721

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of BCOR complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: BCL-6 corepressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168321.1 → NP_001161793.1 BCL-6 corepressor isoform d

See identical proteins and their annotated locations for NP_001161793.1

Status: VALIDATED

Description

Transcript Variant: This variant (e) has an alternate 5' UTR exon and lacks an exon and a segment in the CDS, as compared to variant a. The resulting isoform (d) lacks two internal segments, as compared to isoform a.

Source sequence(s)

AK129398, BC058656

Consensus CDS

CCDS30022.1

UniProtKB/Swiss-Prot

Q8CGN4

Related

ENSMUSP00000048024.7, ENSMUST00000043441.13

Conserved Domains (5) summary

cd00204
Location:1409 → 1517

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1582 → 1698

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1419 → 1510

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1153 → 1365

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1415 → 1446

ANK; ANK repeat [structural motif]
NM_029510.3 → NP_083786.2 BCL-6 corepressor isoform a

See identical proteins and their annotated locations for NP_083786.2

Status: VALIDATED

Description

Transcript Variant: This variant (a) encodes the longest isoform (a).

Source sequence(s)

AK053309, BC058656, CD563463

Consensus CDS

CCDS40873.1

UniProtKB/Swiss-Prot

B1AXK3, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3, Q8CGN4

Related

ENSMUSP00000111175.3, ENSMUST00000115513.9

Conserved Domains (5) summary

cd14261
Location:1634 → 1750

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:257 → 674

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1467 → 1498

ANK; ANK repeat [structural motif]

pfam12796
Location:1471 → 1562

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1205 → 1417

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
NM_175044.3 → NP_778209.2 BCL-6 corepressor isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (b) lacks an exon in the CDS, as compared to variant a. The resulting isoform (b) lacks an internal segment, as compared to isoform a.

Source sequence(s)

AK053309, BC058656, CD563463

Consensus CDS

CCDS40872.1

UniProtKB/Swiss-Prot

Q8CGN4

Related

ENSMUSP00000111174.3, ENSMUST00000115512.9

Conserved Domains (5) summary

cd14261
Location:1616 → 1732

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:257 → 674

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1449 → 1480

ANK; ANK repeat [structural motif]

pfam12796
Location:1453 → 1544

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1187 → 1399

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
NM_175045.3 → NP_778210.2 BCL-6 corepressor isoform c

See identical proteins and their annotated locations for NP_778210.2

Status: VALIDATED

Description

Transcript Variant: This variant (c) lacks a segment in the CDS, as compared to variant a. The resulting isoform (c) lacks an internal segment, as compared to isoform a.

Source sequence(s)

AK053309, BC058656

Consensus CDS

CCDS30021.1

UniProtKB/Swiss-Prot

Q8CGN4

Related

ENSMUSP00000068618.8, ENSMUST00000065143.14

Conserved Domains (5) summary

cd14261
Location:1600 → 1716

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:257 → 674

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1433 → 1464

ANK; ANK repeat [structural motif]

pfam12796
Location:1437 → 1528

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1171 → 1383

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
NM_175046.3 → NP_778211.2 BCL-6 corepressor isoform d

See identical proteins and their annotated locations for NP_778211.2

Status: VALIDATED

Description

Transcript Variant: This variant (d) lacks an exon and a segment in the CDS, as compared to variant a. The resulting isoform (d) lacks two internal segments, as compared to isoform a.

Source sequence(s)

AK053309, BC058656, CD563463

Consensus CDS

CCDS30022.1

UniProtKB/Swiss-Prot

Q8CGN4

Related

ENSMUSP00000116258.2, ENSMUST00000124033.8

Conserved Domains (5) summary

cd00204
Location:1409 → 1517

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1582 → 1698

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1419 → 1510

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1153 → 1365

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1415 → 1446

ANK; ANK repeat [structural motif]

RNA

NR_045434.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (f) lacks several 3' exons and includes three alternate 3' exons. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

BC027704, BP776822

Related

ENSMUST00000209776.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

11902976..12026769 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318623.3 → XP_017174112.1 BCL-6 corepressor isoform X2

UniProtKB/Swiss-Prot

B1AXK3, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3, Q8CGN4

Conserved Domains (5) summary

cd14261
Location:1634 → 1750

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:257 → 674

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1467 → 1498

ANK; ANK repeat [structural motif]

pfam12796
Location:1471 → 1562

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1205 → 1417

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
XM_036162096.1 → XP_036017989.1 BCL-6 corepressor isoform X4

Conserved Domains (5) summary

cd14261
Location:1616 → 1732

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:257 → 674

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1449 → 1480

ANK; ANK repeat [structural motif]

pfam12796
Location:1453 → 1544

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1187 → 1399

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
XM_017318621.3 → XP_017174110.1 BCL-6 corepressor isoform X2

UniProtKB/Swiss-Prot

B1AXK3, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3, Q8CGN4

Conserved Domains (5) summary

cd14261
Location:1634 → 1750

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:257 → 674

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1467 → 1498

ANK; ANK repeat [structural motif]

pfam12796
Location:1471 → 1562

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1205 → 1417

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
XM_036162097.1 → XP_036017990.1 BCL-6 corepressor isoform X4

Conserved Domains (5) summary

cd14261
Location:1616 → 1732

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:257 → 674

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1449 → 1480

ANK; ANK repeat [structural motif]

pfam12796
Location:1453 → 1544

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1187 → 1399

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
XM_017318622.2 → XP_017174111.1 BCL-6 corepressor isoform X2

UniProtKB/Swiss-Prot

B1AXK3, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3, Q8CGN4

Conserved Domains (5) summary

cd14261
Location:1634 → 1750

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:257 → 674

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1467 → 1498

ANK; ANK repeat [structural motif]

pfam12796
Location:1471 → 1562

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1205 → 1417

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
XM_030251500.1 → XP_030107360.1 BCL-6 corepressor isoform X3

Conserved Domains (5) summary

cd14261
Location:1630 → 1746

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:271 → 688

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1463 → 1494

ANK; ANK repeat [structural motif]

pfam12796
Location:1467 → 1558

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1201 → 1413

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
XM_030251499.1 → XP_030107359.1 BCL-6 corepressor isoform X1

Conserved Domains (5) summary

cd14261
Location:1648 → 1764

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:271 → 688

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1481 → 1512

ANK; ANK repeat [structural motif]

pfam12796
Location:1485 → 1576

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1219 → 1431

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
XM_017318624.3 → XP_017174113.1 BCL-6 corepressor isoform X2

UniProtKB/Swiss-Prot

B1AXK3, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3, Q8CGN4

Conserved Domains (5) summary

cd14261
Location:1634 → 1750

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:257 → 674

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1467 → 1498

ANK; ANK repeat [structural motif]

pfam12796
Location:1471 → 1562

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1205 → 1417

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
XM_036162095.1 → XP_036017988.1 BCL-6 corepressor isoform X2

UniProtKB/Swiss-Prot

B1AXK3, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3, Q8CGN4

Conserved Domains (5) summary

cd14261
Location:1634 → 1750

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:257 → 674

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1467 → 1498

ANK; ANK repeat [structural motif]

pfam12796
Location:1471 → 1562

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1205 → 1417

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
XM_036162099.1 → XP_036017992.1 BCL-6 corepressor isoform X6

Conserved Domains (5) summary

cd14261
Location:1600 → 1716

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:257 → 674

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1433 → 1464

ANK; ANK repeat [structural motif]

pfam12796
Location:1437 → 1528

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1171 → 1383

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
XM_036162098.1 → XP_036017991.1 BCL-6 corepressor isoform X6

Conserved Domains (5) summary

cd14261
Location:1600 → 1716

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:257 → 674

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1433 → 1464

ANK; ANK repeat [structural motif]

pfam12796
Location:1437 → 1528

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1171 → 1383

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
XM_030251502.2 → XP_030107362.1 BCL-6 corepressor isoform X6

Conserved Domains (5) summary

cd14261
Location:1600 → 1716

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:257 → 674

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1433 → 1464

ANK; ANK repeat [structural motif]

pfam12796
Location:1437 → 1528

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1171 → 1383

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
XM_030251503.2 → XP_030107363.1 BCL-6 corepressor isoform X7

Conserved Domains (5) summary

cd14261
Location:1596 → 1712

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:271 → 688

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1429 → 1460

ANK; ANK repeat [structural motif]

pfam12796
Location:1433 → 1524

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1167 → 1379

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
XM_030251501.2 → XP_030107361.1 BCL-6 corepressor isoform X5

Conserved Domains (5) summary

cd14261
Location:1614 → 1730

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam05109
Location:271 → 688

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:1447 → 1478

ANK; ANK repeat [structural motif]

pfam12796
Location:1451 → 1542

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1185 → 1397

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region