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Get1 guided entry of tail-anchored proteins factor 1 [ Mus musculus (house mouse) ]

Gene ID: 71446, updated on 9-Dec-2024

Summary

Official Symbol
Get1provided by MGI
Official Full Name
guided entry of tail-anchored proteins factor 1provided by MGI
Primary source
MGI:MGI:2136882
See related
Ensembl:ENSMUSG00000023147 AllianceGenome:MGI:2136882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wrb; Chd5; 5530402J05Rik; C030018G21Rik
Summary
Predicted to enable protein-membrane adaptor activity. Acts upstream of or within several processes, including otic vesicle development; post-translational protein targeting to endoplasmic reticulum membrane; and sensory perception of sound. Predicted to be located in endoplasmic reticulum. Predicted to be part of GET complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and skeleton. Orthologous to human GET1 (guided entry of tail-anchored proteins factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 29.6), whole brain E14.5 (RPKM 25.0) and 26 other tissues See more
Orthologs
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Genomic context

See Get1 in Genome Data Viewer
Location:
16 C4; 16 56.84 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (95946600..95959052)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (96145400..96157852)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41611 Neighboring gene bromodomain and WD repeat domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_41612 Neighboring gene STARR-seq mESC enhancer starr_41614 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:96307304-96307505 Neighboring gene STARR-positive B cell enhancer mm9_chr16:96331382-96331682 Neighboring gene STARR-positive B cell enhancer mm9_chr16:96349246-96349547 Neighboring gene high mobility group nucleosomal binding domain 1 Neighboring gene Leber congenital amaurosis 5-like Neighboring gene STARR-positive B cell enhancer ABC_E7483 Neighboring gene predicted gene, 53923 Neighboring gene SH3-binding domain glutamic acid-rich protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

General gene information

Clone Names

  • MGC98437

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function  
enables protein-membrane adaptor activity  
Process Evidence Code Pubs
acts_upstream_of_or_within establishment of localization in cell PubMed 
acts_upstream_of_or_within otic vesicle development PubMed 
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane PubMed 
involved_in protein insertion into ER membrane  
involved_in protein insertion into ER membrane  
involved_in protein stabilization  
involved_in protein stabilization  
acts_upstream_of_or_within sensory perception of sound PubMed 
acts_upstream_of_or_within sensory perception of sound PubMed 
acts_upstream_of_or_within startle response PubMed 
acts_upstream_of_or_within synapse organization PubMed 
involved_in tail-anchored membrane protein insertion into ER membrane  
involved_in tail-anchored membrane protein insertion into ER membrane  
involved_in tail-anchored membrane protein insertion into ER membrane  
Component Evidence Code Pubs
part_of GET complex  
part_of GET complex  
part_of GET complex  
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum membrane  

General protein information

Preferred Names
guided entry of tail-anchored proteins factor 1
Names
tail-anchored protein insertion receptor WRB
tryptophan rich basic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207301.3NP_997184.1  guided entry of tail-anchored proteins factor 1

    See identical proteins and their annotated locations for NP_997184.1

    Status: VALIDATED

    Source sequence(s)
    AC164647
    Consensus CDS
    CCDS28354.1
    UniProtKB/Swiss-Prot
    Q3TA55, Q8K0D7, Q9D1W0
    Related
    ENSMUSP00000023913.9, ENSMUST00000023913.11
    Conserved Domains (1) summary
    pfam04420
    Location:17163
    CHD5; CHD5-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    95946600..95959052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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