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Flrt3 fibronectin leucine rich transmembrane protein 3 [ Mus musculus (house mouse) ]

Gene ID: 71436, updated on 21-Apr-2024

Summary

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Official Symbol
Flrt3provided by MGI
Official Full Name
fibronectin leucine rich transmembrane protein 3provided by MGI
Primary source
MGI:MGI:1918686
See related
Ensembl:ENSMUSG00000051379 AllianceGenome:MGI:1918686
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1469; 5530600M07Rik; C430047I10Rik
Summary
Enables chemorepellent activity and fibroblast growth factor receptor binding activity. Involved in several processes, including fibroblast growth factor receptor signaling pathway; proepicardium cell migration involved in pericardium morphogenesis; and synapse organization. Acts upstream of or within positive regulation of synapse assembly. Located in several cellular components, including axonal growth cone; cell-cell junction; and glutamatergic synapse. Is integral component of postsynaptic membrane. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; embryo mesenchyme; and eye. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 21 with or without anosmia. Orthologous to human FLRT3 (fibronectin leucine rich transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 7.2), bladder adult (RPKM 5.0) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F3; 2 69.2 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (140500118..140513396, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (140658198..140671476, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05847 Neighboring gene sel-1 suppressor of lin-12-like 2 (C. elegans) Neighboring gene STARR-positive B cell enhancer mm9_chr2:140253034-140253335 Neighboring gene STARR-seq mESC enhancer starr_05848 Neighboring gene STARR-seq mESC enhancer starr_05850 Neighboring gene mono-ADP ribosylhydrolase 2 Neighboring gene predicted gene, 23846 Neighboring gene STARR-seq mESC enhancer starr_05851 Neighboring gene STARR-seq mESC enhancer starr_05853 Neighboring gene STARR-seq mESC enhancer starr_05855 Neighboring gene STARR-seq mESC enhancer starr_05856 Neighboring gene zinc finger, CCHC domain containing 9, pseudogene Neighboring gene mono-ADP ribosylhydrolase 2, opposite strand 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development. Ranaivoson FM, et al. Structure, 2015 Sep 1. PMID 26235031, Free PMC Article
  2. FLRT3 Marks Direction-Selective Retinal Ganglion Cells That Project to the Medial Terminal Nucleus. Ruff T, et al. Front Mol Neurosci, 2021. PMID 34955746, Free PMC Article
  3. Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons. Del Toro D, et al. Cell, 2020 Jan 23. PMID 31928845, Free PMC Article
  4. FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. O'Sullivan ML, et al. Neuron, 2012 Mar 8. PMID 22405201, Free PMC Article
  5. Flrt2 and Flrt3 have overlapping and non-overlapping expression during craniofacial development. Gong SG, et al. Gene Expr Patterns, 2009 Oct. PMID 19635589

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development.
    Title: FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development.
  2. Mice with deletions of FLRT1 and FLRT3 adhesion molecules develop macroscopic sulci with preserved layered organization and radial glial morphology. Cortex folding in these mutants does not require progenitor cell amplification but is dependent on changes in neuron migration.
    Title: Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules.
  3. The crystal structure of the OLF/FLRT3 complex shows that LPHN3-OLF in the closed state binds with high affinity to the concave face of FLRT3-LRR with a combination of hydrophobic and charged residues.
    Title: Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development.
  4. FLRT3 is a modulator of Netrin-1 response in axons.FLRT3 is a Robo1 coreceptor.FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons.
    Title: FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons.
  5. Flrt3 was highly expressed initially in the midbrain.
    Title: Flrt2 and Flrt3 have overlapping and non-overlapping expression during craniofacial development.
  6. Data demonstrate that FLRT3 plays a key role in controlling cell adhesion and tissue morphogenesis in the developing mouse embryo.
    Title: Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3.
  7. FLRT3 has an expression pattern during somite development
    Title: Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in head development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection extension ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proepicardium cell migration involved in pericardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to axon injury ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic membrane adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine-rich repeat transmembrane protein FLRT3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172160.1 → NP_001165631.1  leucine-rich repeat transmembrane protein FLRT3 precursor

    See identical proteins and their annotated locations for NP_001165631.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK031464, AK129369, AL928700, AV157204, BG091701
    Consensus CDS
    CCDS16806.1
    UniProtKB/Swiss-Prot
    Q6ZPQ1, Q8BGT1
    Related
    ENSMUSP00000053399.4, ENSMUST00000056760.4
    Conserved Domains (8) summary
    smart00013
    Location:31 → 61
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:305 → 356
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:107 → 327
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:61 → 84
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:85 → 104
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:413 → 478
    fn3; Fibronectin type III domain
    pfam12799
    Location:61 → 100
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:247 → 306
    LRR_8; Leucine rich repeat

  2. NM_178382.4 → NP_848469.1  leucine-rich repeat transmembrane protein FLRT3 precursor

    See identical proteins and their annotated locations for NP_848469.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK031464, AL928700, AV157204, BG091701
    Consensus CDS
    CCDS16806.1
    UniProtKB/Swiss-Prot
    Q6ZPQ1, Q8BGT1
    Related
    ENSMUSP00000105684.3, ENSMUST00000110057.3
    Conserved Domains (8) summary
    smart00013
    Location:31 → 61
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:305 → 356
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:107 → 327
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:61 → 84
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:85 → 104
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:413 → 478
    fn3; Fibronectin type III domain
    pfam12799
    Location:61 → 100
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:247 → 306
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    140500118..140513396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGT1.1 GenPept UniProtKB/Swiss-Prot:Q8BGT1

Gene LinkOut

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