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Fmnl2 formin-like 2 [ Mus musculus (house mouse) ]

Gene ID: 71409, updated on 3-Apr-2024

Summary

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Official Symbol
Fmnl2provided by MGI
Official Full Name
formin-like 2provided by MGI
Primary source
MGI:MGI:1918659
See related
Ensembl:ENSMUSG00000036053 AllianceGenome:MGI:1918659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Man; 5430425K04Rik
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in cell migration; cortical actin cytoskeleton organization; and regulation of cell shape. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in brain. Orthologous to human FMNL2 (formin like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 13.6), whole brain E14.5 (RPKM 12.6) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C1.1; 2 30.69 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (52747743..53023816)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (52857717..53134202)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta 4 subunit Neighboring gene predicted gene, 46740 Neighboring gene STARR-positive B cell enhancer ABC_E7814 Neighboring gene predicted gene, 46741 Neighboring gene STARR-positive B cell enhancer ABC_E10102 Neighboring gene signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 Neighboring gene STARR-seq mESC enhancer starr_04490 Neighboring gene STARR-seq mESC enhancer starr_04498 Neighboring gene STARR-seq mESC enhancer starr_04499 Neighboring gene predicted gene, 52511 Neighboring gene pre-mRNA processing factor 40A Neighboring gene STARR-positive B cell enhancer ABC_E1005 Neighboring gene STARR-positive B cell enhancer ABC_E7815 Neighboring gene STARR-positive B cell enhancer ABC_E7816 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Caveolin-1 influences epithelial collective cell migration via FMNL2 formin. Katsuno-Kambe H, et al. Biol Cell, 2021 Feb. PMID 33169848
  2. FMNL formins boost lamellipodial force generation. Kage F, et al. Nat Commun, 2017 Mar 22. PMID 28327544, Free PMC Article
  3. Critical roles for multiple formins during cardiac myofibril development and repair. Rosado M, et al. Mol Biol Cell, 2014 Mar. PMID 24430873, Free PMC Article
  4. Formins regulate actin filament flexibility through long range allosteric interactions. Bugyi B, et al. J Biol Chem, 2006 Apr 21. PMID 16490788, Free PMC Article
  5. FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42. Kage F, et al. Sci Rep, 2017 Aug 29. PMID 28852060, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Caveolin-1 influences epithelial collective cell migration via FMNL2 formin.
    Title: Caveolin-1 influences epithelial collective cell migration via FMNL2 formin.
  2. Our data thus link FMNL2/3 formins to actin assembly-dependent functions of Cdc42 in anterograde transport through the Golgi apparatus.
    Title: FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42.
  3. force generation in lamellipodia strongly depends on FMNL formin activity.
    Title: FMNL formins boost lamellipodial force generation.
  4. FMNL1 and FMNL2 are required non-redundantly in the repair of damaged myofibrils.
    Title: Critical roles for multiple formins during cardiac myofibril development and repair.
  5. FMNL2 is a novel elongation factor of actin filaments that constitutes the first Cdc42 effector promoting cell migration and actin polymerization at the tips of lamellipodia.
    Title: FMNL2 drives actin-based protrusion and migration downstream of Cdc42.
  6. mDia1-FH2 has an effect on the conformation of actin filaments
    Title: Formins regulate actin filament flexibility through long range allosteric interactions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular component organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
formin-like protein 2
Names
formin-like domain containing protein MAN
protein Man

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408315.1 → NP_001395244.1  formin-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL844510, AL844859, AL845170
    Related
    ENSMUSP00000088472.5, ENSMUST00000090952.11

  2. NM_001408316.1 → NP_001395245.1  formin-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL844510, AL844859, AL845170
    UniProtKB/Swiss-Prot
    A2APV2, A2AQW1, Q69Z73, Q7TPA8, Q80VH6
    Related
    ENSMUSP00000118658.3, ENSMUST00000127122.9

  3. NM_001408317.1 → NP_001395246.1  formin-like protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL844510, AL844859, AL845170

  4. NM_172409.3 → NP_765997.2  formin-like protein 2 isoform 3

    See identical proteins and their annotated locations for NP_765997.2

    Status: VALIDATED

    Source sequence(s)
    AL844510, AL844859, AL845170
    Consensus CDS
    CCDS38124.1
    UniProtKB/TrEMBL
    E9PXE6, F8VPR2
    Related
    ENSMUSP00000047260.7, ENSMUST00000049483.14
    Conserved Domains (3) summary
    pfam02181
    Location:615 → 966
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    52747743..53023816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498336.3 → XP_006498399.1  formin-like protein 2 isoform X8

    UniProtKB/TrEMBL
    E9PXE6
    Conserved Domains (3) summary
    pfam02181
    Location:571 → 922
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:227 → 424
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23 → 224
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. XM_006498332.4 → XP_006498395.1  formin-like protein 2 isoform X3

    UniProtKB/TrEMBL
    E9PXE6
    Conserved Domains (3) summary
    pfam02181
    Location:622 → 973
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain

  3. XM_006498331.4 → XP_006498394.1  formin-like protein 2 isoform X2

    UniProtKB/TrEMBL
    E9PXE6
    Conserved Domains (3) summary
    pfam02181
    Location:622 → 973
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain

  4. XM_006498334.4 → XP_006498397.1  formin-like protein 2 isoform X5

    UniProtKB/TrEMBL
    E9PXE6
    Conserved Domains (3) summary
    pfam02181
    Location:622 → 973
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain

  5. XM_006498330.3 → XP_006498393.1  formin-like protein 2 isoform X1

    UniProtKB/TrEMBL
    E9PXE6
    Conserved Domains (3) summary
    pfam02181
    Location:622 → 973
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain

  6. XM_006498335.5 → XP_006498398.1  formin-like protein 2 isoform X7

    UniProtKB/TrEMBL
    A2AQW2, E9PXE6
    Related
    ENSMUSP00000117822.3, ENSMUST00000155586.9
    Conserved Domains (3) summary
    pfam02181
    Location:615 → 966
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain

  7. XM_006498337.5 → XP_006498400.1  formin-like protein 2 isoform X9

    Conserved Domains (3) summary
    pfam06367
    Location:278 → 475
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:23 → 275
    Drf_GBD; Diaphanous GTPase-binding Domain
    cl19758
    Location:622 → 806
    FH2; Formin Homology 2 Domain

RNA

  1. XR_003953721.2 RNA Sequence

  2. XR_004940731.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2APV2.2 GenPept UniProtKB/Swiss-Prot:A2APV2

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