Spaar small regulatory polypeptide of amino acid response [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spaarprovided by MGI
Official Full Name: small regulatory polypeptide of amino acid responseprovided by MGI
Primary source: MGI:MGI:1918656
See related: Ensembl:ENSMUSG00000028475 AllianceGenome:MGI:1918656
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spar; 5430416O09Rik
Summary: Involved in cellular response to amino acid stimulus; negative regulation of TORC1 signaling; and regulation of skeletal muscle tissue regeneration. Predicted to be located in late endosome membrane. Predicted to be integral component of lysosomal membrane. Predicted to be part of lysosomal proton-transporting V-type ATPase complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; and sensory organ. Orthologous to human SPAAR (small regulatory polypeptide of amino acid response). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 4.1), lung adult (RPKM 3.0) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 23.05 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (43730045..43732084)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (43730034..43734534)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Influence of the LINC00961/SPAAR Locus Loss on Murine Development, Myocardial Dynamics, and Cardiac Response to Myocardial Infarction.
Title: The Influence of the LINC00961/SPAAR Locus Loss on Murine Development, Myocardial Dynamics, and Cardiac Response to Myocardial Infarction.
The LINC00961 transcript and its encoded micropeptide, small regulatory polypeptide of amino acid response, regulate endothelial cell function.
Title: The LINC00961 transcript and its encoded micropeptide, small regulatory polypeptide of amino acid response, regulate endothelial cell function.
data provide a mechanism by which mTORC1 activation may be finely regulated in a tissue-specific manner in response to injury, and a paradigm by which lncRNAs encoding small polypeptides like SPAR can modulate general biological pathways and processes to facilitate tissue-specific requirements, consistent with their restricted and highly regulated expression profile
Title: mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
part_of lysosomal proton-transporting V-type ATPase complex	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: small regulatory polypeptide of amino acid response

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348108.2 → NP_001335037.1 small regulatory polypeptide of amino acid response

Status: VALIDATED

Source sequence(s)

AL824712

Consensus CDS

CCDS89739.1

UniProtKB/Swiss-Prot

A0A1B0GSZ0

Related

ENSMUSP00000148128.2, ENSMUST00000131248.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

43730045..43732084

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_027789.3: Suppressed sequence

Description

NM_027789.3: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.