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Arid5b AT-rich interaction domain 5B [ Mus musculus (house mouse) ]

Gene ID: 71371, updated on 21-Apr-2024

Summary

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Official Symbol
Arid5bprovided by MGI
Official Full Name
AT-rich interaction domain 5Bprovided by MGI
Primary source
MGI:MGI:2175912
See related
Ensembl:ENSMUSG00000019947 AllianceGenome:MGI:2175912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrf2; Desrt; Mrf2beta; Mrf2alpha; 4930580B11; 5430435G07Rik
Summary
Predicted to enable transcription cis-regulatory region binding activity and transcription coactivator activity. Involved in adipose tissue development. Acts upstream of or within several processes, including animal organ development; cellular response to leukemia inhibitory factor; and face morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human ARID5B (AT-rich interaction domain 5B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 5.8), bladder adult (RPKM 5.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B5.1- B5.2; 10 35.14 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (67928353..68114596, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (68092523..68279355, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930521O17 gene Neighboring gene STARR-positive B cell enhancer ABC_E5144 Neighboring gene rhotekin 2 Neighboring gene STARR-seq mESC enhancer starr_27014 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:67544592-67544803 Neighboring gene STARR-seq mESC enhancer starr_27016 Neighboring gene STARR-seq mESC enhancer starr_27019 Neighboring gene STARR-seq mESC enhancer starr_27023 Neighboring gene STARR-positive B cell enhancer ABC_E9344 Neighboring gene predicted gene, 51770 Neighboring gene STARR-seq mESC enhancer starr_27025 Neighboring gene STARR-seq mESC enhancer starr_27026 Neighboring gene STARR-positive B cell enhancer ABC_E8342 Neighboring gene STARR-positive B cell enhancer ABC_E3891 Neighboring gene STARR-positive B cell enhancer ABC_E5145 Neighboring gene STARR-seq mESC enhancer starr_27031 Neighboring gene STARR-seq mESC enhancer starr_27032 Neighboring gene STARR-seq mESC enhancer starr_27034 Neighboring gene STARR-positive B cell enhancer ABC_E10619 Neighboring gene STARR-positive B cell enhancer ABC_E8343 Neighboring gene STARR-positive B cell enhancer ABC_E10620 Neighboring gene STARR-seq mESC enhancer starr_27036 Neighboring gene STARR-seq mESC enhancer starr_27037 Neighboring gene STARR-seq mESC enhancer starr_27038 Neighboring gene RIKEN cDNA 4930545H06 gene Neighboring gene predicted gene, 32748

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Muscle-specific deletion of Arid5b causes metabolic changes in skeletal muscle that affect adipose tissue and liver. Murray J, et al. Front Endocrinol (Lausanne), 2022. PMID 36743919, Free PMC Article
  2. ARID5B influences B-cell development and function in mouse. Goodings C, et al. Haematologica, 2023 Feb 1. PMID 35924577, Free PMC Article
  3. Reduced prostaglandin I(2) signaling in Arid5b(-/-) primary skeletal muscle cells attenuates myogenesis. Murray J, et al. FASEB J, 2018 Apr. PMID 29196500, Free PMC Article
  4. Modulator recognition factor-2 regulates triglyceride metabolism in adipocytes. Yamakawa T, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19913508
  5. Regulation of smooth muscle cell differentiation by AT-rich interaction domain transcription factors Mrf2alpha and Mrf2beta. Watanabe M, et al. Circ Res, 2002 Sep 6. PMID 12215486

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development.
    Title: ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development.
  2. ARID5B influences B-cell development and function in mouse.
    Title: ARID5B influences B-cell development and function in mouse.
  3. Muscle-specific deletion of Arid5b causes metabolic changes in skeletal muscle that affect adipose tissue and liver.
    Title: Muscle-specific deletion of Arid5b causes metabolic changes in skeletal muscle that affect adipose tissue and liver.
  4. Mice with Fabp4-Cre ablation of Arid5b are resistant to diet-induced obesity and hepatic steatosis.
    Title: Mice with Fabp4-Cre ablation of Arid5b are resistant to diet-induced obesity and hepatic steatosis.
  5. Arid5b KO reduces prostaglandin I2 signaling in primary skeletal muscle cells and attenuates myogenesis.
    Title: Reduced prostaglandin I(2) signaling in Arid5b(-/-) primary skeletal muscle cells attenuates myogenesis.
  6. These results strongly suggest that p62 plays a crucial role in preventing fenofibrate-induced cell death.
    Title: Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation.
  7. Arid5b recruits Phf2 to the promoter region of Sox9 target genes and stimulates H3K9me2 demethylation of these genes.
    Title: Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes.
  8. knockdown of Mrf-2 increases the rate of fatty acid recycling in 3T3-L1-derived adipocytes.
    Title: Modulator recognition factor-2 regulates triglyceride metabolism in adipocytes.
  9. Data suggest that Mrf-2 facilitates the induction of key adipogenic transcription factors C/EBPalpha and peroxisome proliferator-activated receptor-gamma.
    Title: Modulator recognition factor-2 is required for adipogenesis in mouse embryo fibroblasts and 3T3-L1 cells.
  10. These results indicate that Mrf2 can be a potential regulator of adipocyte differentiation and a potential repressor of leptin.
    Title: Role of modulator recognition factor 2 in adipogenesis and leptin expression in 3T3-L1 cells.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adipose tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adrenal gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within face morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fat pad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within female gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nitrogen compound metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
AT-rich interactive domain-containing protein 5B
Names
ARID class DNA binding protein
ARID domain-containing protein 5B
AT rich interactive domain 5B (MRF1-like)
AT rich interactive domain 5B (Mrf1 like)
MRF-2
developmentally and sexually retarded with transient immune abnormalities protein
modulator recognition factor 2
modulator recognition factor protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023598.2 → NP_076087.2  AT-rich interactive domain-containing protein 5B

    See identical proteins and their annotated locations for NP_076087.2

    Status: VALIDATED

    Source sequence(s)
    AK029818, AK034633, BY717211, BY720203, CD543091, CN665657
    Consensus CDS
    CCDS35929.1
    UniProtKB/Swiss-Prot
    E9Q523, Q8BM75, Q8C0E0, Q8K4G8, Q8K4L9, Q9CU78, Q9JIX4
    Related
    ENSMUSP00000151227.2, ENSMUST00000219238.2
    Conserved Domains (2) summary
    PTZ00121
    Location:411 → 536
    PTZ00121; MAEBL; Provisional
    cd16885
    Location:321 → 415
    ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    67928353..68114596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245282.2 → XP_030101142.1  AT-rich interactive domain-containing protein 5B isoform X3

    Conserved Domains (2) summary
    PTZ00121
    Location:222 → 347
    PTZ00121; MAEBL; Provisional
    cd16885
    Location:132 → 226
    ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins

  2. XM_006514129.4 → XP_006514192.1  AT-rich interactive domain-containing protein 5B isoform X1

    Conserved Domains (2) summary
    PTZ00121
    Location:437 → 562
    PTZ00121; MAEBL; Provisional
    cd16885
    Location:347 → 441
    ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins

  3. XM_006514132.2 → XP_006514195.1  AT-rich interactive domain-containing protein 5B isoform X3

    See identical proteins and their annotated locations for XP_006514195.1

    Conserved Domains (2) summary
    PTZ00121
    Location:222 → 347
    PTZ00121; MAEBL; Provisional
    cd16885
    Location:132 → 226
    ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins

  4. XM_006514131.4 → XP_006514194.1  AT-rich interactive domain-containing protein 5B isoform X2

    Related
    ENSMUSP00000151665.2, ENSMUST00000218532.2
    Conserved Domains (2) summary
    PTZ00121
    Location:225 → 350
    PTZ00121; MAEBL; Provisional
    cd16885
    Location:135 → 229
    ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins

  5. XM_036156016.1 → XP_036011909.1  AT-rich interactive domain-containing protein 5B isoform X4

    Conserved Domains (2) summary
    PTZ00121
    Location:79 → 204
    PTZ00121; MAEBL; Provisional
    cl28902
    Location:1 → 83
    ARID; ARID/BRIGHT DNA binding domain family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BM75.3 GenPept UniProtKB/Swiss-Prot:Q8BM75

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