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Fsip1 fibrous sheath-interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 71313, updated on 5-Mar-2024

Summary

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Official Symbol
Fsip1provided by MGI
Official Full Name
fibrous sheath-interacting protein 1provided by MGI
Primary source
MGI:MGI:1918563
See related
Ensembl:ENSMUSG00000027344 AllianceGenome:MGI:1918563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700012M13Rik; 4933432K11Rik
Summary
Predicted to be located in motile cilium. Orthologous to human FSIP1 (fibrous sheath interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 5.2), CNS E18 (RPKM 0.8) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E5; 2 59.38 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (117960742..118087468, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118130261..118256987, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13986 Neighboring gene STARR-positive B cell enhancer mm9_chr2:117936762-117937062 Neighboring gene predicted gene, 25308 Neighboring gene thrombospondin 1 Neighboring gene STARR-seq mESC enhancer starr_05456 Neighboring gene STARR-positive B cell enhancer ABC_E7849 Neighboring gene STARR-positive B cell enhancer mm9_chr2:118089004-118089305 Neighboring gene STARR-seq mESC enhancer starr_05457 Neighboring gene RIKEN cDNA 1700054M17 gene Neighboring gene STARR-seq mESC enhancer starr_05459 Neighboring gene G protein-coupled receptor 176 Neighboring gene STARR-positive B cell enhancer ABC_E1594 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bi-allelic mutation in Fsip1 impairs acrosome vesicle formation and attenuates flagellogenesis in mice. Gamallat Y, et al. Redox Biol, 2021 Jul. PMID 33901807, Free PMC Article
  2. A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. Brown PR, et al. Biol Reprod, 2003 Jun. PMID 12606363
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in motile cilium IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
fibrous sheath-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374672.1 → NP_001361601.1  fibrous sheath-interacting protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL845495
    Consensus CDS
    CCDS89537.1
    UniProtKB/TrEMBL
    A0A2R8W6Q5
    Related
    ENSMUSP00000155242.2, ENSMUST00000231133.2
    Conserved Domains (1) summary
    pfam15554
    Location:4 → 405
    FSIP1; FSIP1 family

  2. NM_027759.3 → NP_082035.1  fibrous sheath-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_082035.1

    Status: VALIDATED

    Source sequence(s)
    AK017026, AL845495
    Consensus CDS
    CCDS16573.1
    UniProtKB/Swiss-Prot
    Q8R4I9, Q9D3V5, Q9DAD8
    Related
    ENSMUSP00000028821.4, ENSMUST00000028821.10
    Conserved Domains (1) summary
    pfam15554
    Location:4 → 405
    FSIP1; FSIP1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    117960742..118087468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500175.2 → XP_006500238.1  fibrous sheath-interacting protein 1 isoform X1

    Conserved Domains (1) summary
    pfam15554
    Location:34 → 435
    FSIP1; FSIP1 family

  2. XM_006500176.3 → XP_006500239.1  fibrous sheath-interacting protein 1 isoform X2

    Conserved Domains (1) summary
    pfam15554
    Location:34 → 434
    FSIP1; FSIP1 family

  3. XM_030252079.1 → XP_030107939.1  fibrous sheath-interacting protein 1 isoform X5

    Conserved Domains (1) summary
    pfam15554
    Location:4 → 404
    FSIP1; FSIP1 family

  4. XM_006500179.2 → XP_006500242.1  fibrous sheath-interacting protein 1 isoform X4

    Conserved Domains (1) summary
    pfam15554
    Location:34 → 434
    FSIP1; FSIP1 family

  5. XM_006500178.2 → XP_006500241.1  fibrous sheath-interacting protein 1 isoform X3

    Conserved Domains (1) summary
    pfam15554
    Location:34 → 435
    FSIP1; FSIP1 family

RNA

  1. XR_001783179.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3V5.1 GenPept UniProtKB/Swiss-Prot:Q9D3V5

Gene LinkOut

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