U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Crnde colorectal neoplasia differentially expressed, non-protein coding [ Mus musculus (house mouse) ]

Gene ID: 71296, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Crndeprovided by MGI
Official Full Name
colorectal neoplasia differentially expressed, non-protein codingprovided by MGI
Primary source
MGI:MGI:1918546
See related
Ensembl:ENSMUSG00000031736 AllianceGenome:MGI:1918546
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933436C20Rik
Summary
Acts upstream of or within positive regulation of gene expression. Is expressed in forebrain and retina. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 11.0), CNS E11.5 (RPKM 9.8) and 13 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8 C5; 8 44.89 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (93052661..93082739, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (92326031..92356120, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22316 Neighboring gene predicted gene 28516 Neighboring gene predicted gene, 24254 Neighboring gene STARR-seq mESC enhancer starr_22318 Neighboring gene STARR-seq mESC enhancer starr_22319 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:94853262-94853449 Neighboring gene STARR-positive B cell enhancer ABC_E2871 Neighboring gene Iroquois homeobox 5 Neighboring gene STARR-seq mESC enhancer starr_22322 Neighboring gene Iroquois homeobox 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. lncRNA CRNDE Affects Th17/IL-17A and Inhibits Epithelial-Mesenchymal Transition in Lung Epithelial Cells Reducing Asthma Signs. Yuan Y, et al. Oxid Med Cell Longev, 2023. PMID 36743692, Free PMC Article
  2. LncRNA CRNDE is involved in radiation resistance in hepatocellular carcinoma via modulating the SP1/PDK1 axis. Chen KY, et al. Neoplasma, 2022 Jul. PMID 35652619
  3. LncRNA CRNDE inhibits cardiomyocytes apoptosis by YAP1 in myocardial ischaemia/reperfusion injury. Zhu X, et al. Autoimmunity, 2021 Jun. PMID 33988471
  4. Effect of lncRNA CRNDE on sepsis-related kidney injury through the TLR3/NF-κB pathway. Sun BQ, et al. Eur Rev Med Pharmacol Sci, 2019 Dec. PMID 31841203
  5. The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in mice. Mulati M, et al. Bone, 2020 Jan. PMID 31622775

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lncRNA CRNDE Affects Th17/IL-17A and Inhibits Epithelial-Mesenchymal Transition in Lung Epithelial Cells Reducing Asthma Signs.
    Title: lncRNA CRNDE Affects Th17/IL-17A and Inhibits Epithelial-Mesenchymal Transition in Lung Epithelial Cells Reducing Asthma Signs.
  2. LncRNA CRNDE is involved in radiation resistance in hepatocellular carcinoma via modulating the SP1/PDK1 axis.
    Title: LncRNA CRNDE is involved in radiation resistance in hepatocellular carcinoma via modulating the SP1/PDK1 axis.
  3. LncRNA CRNDE inhibits cardiomyocytes apoptosis by YAP1 in myocardial ischaemia/reperfusion injury.
    Title: LncRNA CRNDE inhibits cardiomyocytes apoptosis by YAP1 in myocardial ischaemia/reperfusion injury.
  4. LncRNA CRNDE is activated by SP1 and promotes osteosarcoma proliferation, invasion, and epithelial-mesenchymal transition via Wnt/beta-catenin signaling pathway.
    Title: LncRNA CRNDE is activated by SP1 and promotes osteosarcoma proliferation, invasion, and epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway.
  5. The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/beta-catenin signaling pathway in mice.
    Title: The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in mice.
  6. Effect of lncRNA CRNDE on sepsis-related kidney injury through the TLR3/NF-kappaB pathway.
    Title: Effect of lncRNA CRNDE on sepsis-related kidney injury through the TLR3/NF-κB pathway.
  7. Overexpression of Crnde attenuated cardiac fibrosis and enhanced cardiac function in mice with DCM. Further, in vitro experiments showed that Crnde negatively regulates the myofibroblast differentiation of CFs. The expression of Crnde was activated by SMAD family member 3 (Smad3). Crnde also inhibited the transcriptional activation of Smad3 on target genes.
    Title: Long noncoding RNA Crnde attenuates cardiac fibrosis via Smad3-Crnde negative feedback in diabetic cardiomyopathy.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_033641.4 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC155166
    Related
    ENSMUST00000034183.11

  2. NR_110452.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two internal exons, contains an alternate internal exon, and differs in the 3' exon structure, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AC155166

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    93052661..93082739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials