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Cpvl carboxypeptidase, vitellogenic-like [ Mus musculus (house mouse) ]

Gene ID: 71287, updated on 11-Apr-2024

Summary

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Official Symbol
Cpvlprovided by MGI
Official Full Name
carboxypeptidase, vitellogenic-likeprovided by MGI
Primary source
MGI:MGI:1918537
See related
Ensembl:ENSMUSG00000052955 AllianceGenome:MGI:1918537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HVLP; 4933436L16Rik
Summary
This gene encodes a member of the serine carboxypeptidase family of proteases that cleave amino acids from the C-terminus of a protein substrate. The human ortholog of this gene, where it was first characterized, was found to be upregulated during the maturation of monocytes to macrophages. The encoded protein may be involved in antigen processing, digestion of phagocytosed proteins in the lysosome and lamellipodium formation. Disruption of this gene in mice was found to cause embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Expression
Restricted expression toward testis adult (RPKM 4.9) See more
Orthologs
human all
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Genomic context

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Location:
6 B3; 6 26.19 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (53850106..53955658, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (53873121..53978673, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15935 Neighboring gene predicted gene 16499 Neighboring gene STARR-seq mESC enhancer starr_15936 Neighboring gene STARR-seq mESC enhancer starr_15937 Neighboring gene predicted gene, 22910 Neighboring gene predicted gene, 33716 Neighboring gene RIKEN cDNA 4921529L05 gene Neighboring gene STARR-seq mESC enhancer starr_15940 Neighboring gene STARR-seq mESC enhancer starr_15942 Neighboring gene chimerin 2 Neighboring gene RIKEN cDNA 9530036M11 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tagged mutagenesis by efficient Minos-based germ line transposition. de Wit T, et al. Mol Cell Biol, 2010 Jan. PMID 19884347, Free PMC Article
  2. Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice. Srivastava U, et al. Arterioscler Thromb Vasc Biol, 2012 Oct. PMID 22837474, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Carboxypeptidase Vitellogenic-Like Promotes the Proliferation and Metastasis of Osteosarcoma through the TGF-beta/Smad Signaling Pathway.
    Title: Carboxypeptidase Vitellogenic-Like Promotes the Proliferation and Metastasis of Osteosarcoma through the TGF-β/Smad Signaling Pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1)  1 citation
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable serine carboxypeptidase CPVL
NP_001276642.1
NP_001276643.1
NP_082025.1
XP_006506676.1
XP_006506678.1
XP_006506680.1
XP_006506682.1
XP_006506683.1
XP_006506684.1
XP_006506685.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289713.1 → NP_001276642.1  probable serine carboxypeptidase CPVL isoform 1 precursor

    See identical proteins and their annotated locations for NP_001276642.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK017087, BC137839
    Consensus CDS
    CCDS51777.1
    UniProtKB/Swiss-Prot
    B2RQB1, Q9D3S9
    UniProtKB/TrEMBL
    B7ZN25
    Related
    ENSMUSP00000144942.2, ENSMUST00000204674.3
    Conserved Domains (1) summary
    pfam00450
    Location:72 → 468
    Peptidase_S10; Serine carboxypeptidase

  2. NM_001289714.1 → NP_001276643.1  probable serine carboxypeptidase CPVL isoform 2 precursor

    See identical proteins and their annotated locations for NP_001276643.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK017087
    Consensus CDS
    CCDS85050.1
    UniProtKB/TrEMBL
    B7ZN25
    Related
    ENSMUSP00000145288.2, ENSMUST00000203101.3
    Conserved Domains (1) summary
    cl08270
    Location:72 → 424
    Peptidase_S10; Serine carboxypeptidase

  3. NM_027749.2 → NP_082025.1  probable serine carboxypeptidase CPVL isoform 1 precursor

    See identical proteins and their annotated locations for NP_082025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK017087, BC137839
    Consensus CDS
    CCDS51777.1
    UniProtKB/Swiss-Prot
    B2RQB1, Q9D3S9
    UniProtKB/TrEMBL
    B7ZN25
    Related
    ENSMUSP00000131462.2, ENSMUST00000166545.2
    Conserved Domains (1) summary
    pfam00450
    Location:72 → 468
    Peptidase_S10; Serine carboxypeptidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    53850106..53955658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506615.4 → XP_006506678.1  probable serine carboxypeptidase CPVL isoform X2

    See identical proteins and their annotated locations for XP_006506678.1

    UniProtKB/Swiss-Prot
    B2RQB1, Q9D3S9
    UniProtKB/TrEMBL
    B7ZN25
    Conserved Domains (1) summary
    pfam00450
    Location:72 → 468
    Peptidase_S10; Serine carboxypeptidase

  2. XM_006506619.3 → XP_006506682.1  probable serine carboxypeptidase CPVL isoform X4

    UniProtKB/TrEMBL
    B7ZN25
    Conserved Domains (1) summary
    cl08270
    Location:78 → 389
    Peptidase_S10; Serine carboxypeptidase

  3. XM_006506617.2 → XP_006506680.1  probable serine carboxypeptidase CPVL isoform X3

    UniProtKB/TrEMBL
    B7ZN25
    Conserved Domains (1) summary
    cl08270
    Location:78 → 430
    Peptidase_S10; Serine carboxypeptidase

  4. XM_006506613.2 → XP_006506676.1  probable serine carboxypeptidase CPVL isoform X1

    UniProtKB/TrEMBL
    B7ZN25
    Conserved Domains (1) summary
    pfam00450
    Location:78 → 474
    Peptidase_S10; Serine carboxypeptidase

  5. XM_006506622.4 → XP_006506685.1  probable serine carboxypeptidase CPVL isoform X5

    See identical proteins and their annotated locations for XP_006506685.1

    Conserved Domains (1) summary
    cl08270
    Location:1 → 319
    Peptidase_S10; Serine carboxypeptidase

  6. XM_006506620.4 → XP_006506683.1  probable serine carboxypeptidase CPVL isoform X5

    See identical proteins and their annotated locations for XP_006506683.1

    Conserved Domains (1) summary
    cl08270
    Location:1 → 319
    Peptidase_S10; Serine carboxypeptidase

  7. XM_006506621.2 → XP_006506684.1  probable serine carboxypeptidase CPVL isoform X5

    See identical proteins and their annotated locations for XP_006506684.1

    Conserved Domains (1) summary
    cl08270
    Location:1 → 319
    Peptidase_S10; Serine carboxypeptidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3S9.2 GenPept UniProtKB/Swiss-Prot:Q9D3S9

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