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Mro maestro [ Mus musculus (house mouse) ]

Gene ID: 71263, updated on 3-Apr-2024

Summary

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Official Symbol
Mroprovided by MGI
Official Full Name
maestroprovided by MGI
Primary source
MGI:MGI:2152817
See related
Ensembl:ENSMUSG00000064036 AllianceGenome:MGI:2152817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930507C04Rik; 4933435E20Rik
Summary
Located in nucleolus. Is expressed in reproductive system. Orthologous to human MRO (maestro). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 3.0), ovary adult (RPKM 2.7) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E2; 18 50.21 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (73992465..74014405)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (73851826..73881334)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene malic enzyme 2, NAD(+)-dependent, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E11003 Neighboring gene STARR-seq mESC enhancer starr_44997 Neighboring gene predicted gene, 52346 Neighboring gene predicted gene, 32661 Neighboring gene mitogen-activated protein kinase 4 Neighboring gene RIKEN cDNA D730045A05 gene Neighboring gene STARR-seq mESC enhancer starr_45000 Neighboring gene predicted gene 9925

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Candidate testis-determining gene, Maestro (Mro), encodes a novel HEAT repeat protein. Smith L, et al. Dev Dyn, 2003 Aug. PMID 12889070
  2. The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice. Smith L, et al. PLoS One, 2008. PMID 19116663, Free PMC Article
  3. A gene-driven ENU-based approach to generating an allelic series in any gene. Quwailid MM, et al. Mamm Genome, 2004 Aug. PMID 15457338
  4. Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development. Bouma GJ, et al. Gene Expr Patterns, 2004 Nov. PMID 15533830
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Maestro is dispensable for normal male sexual development and fertility in laboratory mice
    Title: The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein maestro
Names
male-specific transcription in the developing reproductive organs

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305882.2 → NP_001292811.1  protein maestro isoform 1

    See identical proteins and their annotated locations for NP_001292811.1

    Status: VALIDATED

    Source sequence(s)
    AC124367
    Consensus CDS
    CCDS79663.1
    UniProtKB/Swiss-Prot
    Q7TNB4, Q9D3T8
    UniProtKB/TrEMBL
    E9QNX2
    Related
    ENSMUSP00000113434.2, ENSMUST00000120033.8
    Conserved Domains (1) summary
    sd00044
    Location:46 → 74
    HEAT; HEAT repeat [structural motif]

  2. NM_001360973.2 → NP_001347902.1  protein maestro isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124367
    Conserved Domains (1) summary
    sd00044
    Location:183 → 211
    HEAT; HEAT repeat [structural motif]

  3. NM_001403901.1 → NP_001390830.1  protein maestro isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC124367

  4. NM_001403902.1 → NP_001390831.1  protein maestro isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124367

  5. NM_001403903.1 → NP_001390832.1  protein maestro isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124367

  6. NM_001403904.1 → NP_001390833.1  protein maestro isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC124367

  7. NM_001403905.1 → NP_001390834.1  protein maestro isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC124367

  8. NM_001403906.1 → NP_001390835.1  protein maestro isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC124367

  9. NM_001403907.1 → NP_001390836.1  protein maestro isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC124367

  10. NM_001403908.1 → NP_001390837.1  protein maestro isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124367
    UniProtKB/TrEMBL
    E9QNX2
    Related
    ENSMUSP00000136775.2, ENSMUST00000179472.8

  11. NM_001403909.1 → NP_001390838.1  protein maestro isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124367
    UniProtKB/TrEMBL
    E9PUF9

  12. NM_001403910.1 → NP_001390839.1  protein maestro isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC124367

  13. NM_001403911.1 → NP_001390840.1  protein maestro isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC124367

  14. NM_027741.4 → NP_082017.2  protein maestro isoform 2

    See identical proteins and their annotated locations for NP_082017.2

    Status: VALIDATED

    Source sequence(s)
    AC124367
    Consensus CDS
    CCDS50319.1
    UniProtKB/Swiss-Prot
    Q7TNB4, Q9D3T8
    UniProtKB/TrEMBL
    E9PUF9
    Related
    ENSMUSP00000113392.2, ENSMUST00000119239.8
    Conserved Domains (1) summary
    sd00044
    Location:46 → 74
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_175778.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124367

  2. NR_175779.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124367

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    73992465..74014405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161280.1 → XP_036017173.1  protein maestro isoform X13

  2. XM_017317980.3 → XP_017173469.1  protein maestro isoform X6

  3. XM_036161278.1 → XP_036017171.1  protein maestro isoform X3

    Conserved Domains (1) summary
    sd00044
    Location:183 → 211
    HEAT; HEAT repeat [structural motif]

  4. XM_030250600.2 → XP_030106460.1  protein maestro isoform X12

    UniProtKB/Swiss-Prot
    Q7TNB4, Q9D3T8
    UniProtKB/TrEMBL
    E9PUF9
    Conserved Domains (1) summary
    sd00044
    Location:46 → 74
    HEAT; HEAT repeat [structural motif]

  5. XM_030250599.2 → XP_030106459.1  protein maestro isoform X11

    UniProtKB/Swiss-Prot
    Q7TNB4, Q9D3T8
    UniProtKB/TrEMBL
    E9QNX2
    Conserved Domains (1) summary
    sd00044
    Location:46 → 74
    HEAT; HEAT repeat [structural motif]

  6. XM_006526251.5 → XP_006526314.1  protein maestro isoform X4

    Conserved Domains (1) summary
    sd00044
    Location:176 → 208
    HEAT; HEAT repeat [structural motif]

  7. XM_006526260.5 → XP_006526323.1  protein maestro isoform X11

    See identical proteins and their annotated locations for XP_006526323.1

    UniProtKB/Swiss-Prot
    Q7TNB4, Q9D3T8
    UniProtKB/TrEMBL
    E9QNX2
    Conserved Domains (1) summary
    sd00044
    Location:46 → 74
    HEAT; HEAT repeat [structural motif]

  8. XM_036161282.1 → XP_036017175.1  protein maestro isoform X18

    Conserved Domains (1) summary
    sd00044
    Location:9 → 41
    HEAT; HEAT repeat [structural motif]

  9. XM_036161283.1 → XP_036017176.1  protein maestro isoform X18

    Conserved Domains (1) summary
    sd00044
    Location:9 → 41
    HEAT; HEAT repeat [structural motif]

RNA

  1. XR_003952542.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNB4.1 GenPept UniProtKB/Swiss-Prot:Q7TNB4

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