Dmrtc2 doublesex and mab-3 related transcription factor like family C2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmrtc2provided by MGI
Official Full Name: doublesex and mab-3 related transcription factor like family C2provided by MGI
Primary source: MGI:MGI:1918491
See related: Ensembl:ENSMUSG00000011349 AllianceGenome:MGI:1918491
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dmrt7; 4933432E21Rik
Summary: Enables identical protein binding activity and sequence-specific DNA binding activity. Acts upstream of or within male gamete generation and positive regulation of histone H3-K9 methylation. Located in XY body. Is expressed in branchial arch; genital tubercle; gonad; heart; and limb. Orthologous to human DMRTC2 (DMRT like family C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 39.5) See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 13.33 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24569242..24577080)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (24869817..24877655)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dmrt7 is critical for the normal pachytene spermatogenesis and complete meiotic recombination.
Title: Impairment of pachytene spermatogenesis in Dmrt7 deficient mice, possibly causing meiotic arrest.
Data suggests that NF-Y can activate the Dmrt7 promoter by binding to the tandem CCAAT boxes .
Title: Nuclear factor-Y (NF-Y) regulates transcription of mouse Dmrt7 gene by binding to tandem CCAAT boxes in its proximal promoter.
study demonstrated that Dmrt7 had unique sexually dimorphic expression patterns in transcripts that associated with spermatocyte-specific translation, but not in ovary
Title: Male-specific function of Dmrt7 by sexually dimorphic translation in mouse testis.
decreased expression of Ccna1 mRNA and the accumulation of SCP3-positive spermatocytes showed the arrest of spermatogenesis at the pachytene stage in the Dmrt7-knockout mice.
Title: Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage.
DMRT7 may help control the transition from meiotic sex chromosome inactivation to postmeiotic sex chromatin in males.
Title: A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Chemically induced (ENU) (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dmrtc2 (e-PCR), detects polymorphism
- UniSTS:474726

Dmrtc2 (e-PCR), detects polymorphism
- UniSTS:257215

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
NOT enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
NOT enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heterochromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sex differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatid nucleus elongation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in XY body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: doublesex- and mab-3-related transcription factor C2

Names: doublesex and mab-3 related transcription factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027732.2 → NP_082008.1 doublesex- and mab-3-related transcription factor C2

See identical proteins and their annotated locations for NP_082008.1

Status: VALIDATED

Source sequence(s)

AC161441, AF542046

Consensus CDS

CCDS20965.1

UniProtKB/Swiss-Prot

A6H6T0, Q8CGW9

Related

ENSMUSP00000011493.6, ENSMUST00000011493.6

Conserved Domains (2) summary

pfam00751
Location:38 → 84

DM; DM DNA binding domain

pfam15791
Location:242 → 369

DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

24569242..24577080

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540359.4 → XP_006540422.1 doublesex- and mab-3-related transcription factor C2 isoform X3

See identical proteins and their annotated locations for XP_006540422.1

UniProtKB/Swiss-Prot

A6H6T0, Q8CGW9

Conserved Domains (2) summary

pfam00751
Location:38 → 84

DM; DM DNA binding domain

pfam15791
Location:242 → 369

DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
XM_006540358.3 → XP_006540421.1 doublesex- and mab-3-related transcription factor C2 isoform X2

Conserved Domains (2) summary

pfam00751
Location:48 → 94

DM; DM DNA binding domain

pfam15791
Location:252 → 379

DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
XM_017312307.1 → XP_017167796.1 doublesex- and mab-3-related transcription factor C2 isoform X1

Conserved Domains (2) summary

pfam00751
Location:69 → 115

DM; DM DNA binding domain

pfam15791
Location:273 → 400

DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2