U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sdhaf3 succinate dehydrogenase complex assembly factor 3 [ Mus musculus (house mouse) ]

Gene ID: 71238, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Sdhaf3provided by MGI
Official Full Name
succinate dehydrogenase complex assembly factor 3provided by MGI
Primary source
MGI:MGI:1913288
See related
Ensembl:ENSMUSG00000042505 AllianceGenome:MGI:1913288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acn9; 0610005M07Rik; 4933430A16Rik
Summary
Predicted to be involved in mitochondrial respiratory chain complex II assembly and succinate metabolic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial intermembrane space. Orthologous to human SDHAF3 (succinate dehydrogenase complex assembly factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.0), CNS E14 (RPKM 2.9) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sdhaf3 in Genome Data Viewer
Location:
6 A1; 6 2.83 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (6956004..7039661)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (6955971..7039661)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53323 Neighboring gene STARR-seq mESC enhancer starr_15088 Neighboring gene predicted gene, 22155 Neighboring gene centromere protein E pseudogene Neighboring gene STARR-seq mESC enhancer starr_15089 Neighboring gene predicted gene, 19272

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Acn9 is a novel protein of gluconeogenesis that is located in the mitochondrial intermembrane space. Dennis RA, et al. Eur J Biochem, 1999 Apr. PMID 10103055
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex II assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in succinate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
succinate dehydrogenase assembly factor 3, mitochondrial
Names
ACN9 homolog
SDH assembly factor 3
protein ACN9 homolog, mitochondrial

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077713.2 → NP_001071181.1  succinate dehydrogenase assembly factor 3, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_001071181.1

    Status: VALIDATED

    Source sequence(s)
    AC122240, AC146599
    Consensus CDS
    CCDS39423.1
    UniProtKB/Swiss-Prot
    Q8BQU3, Q8BT21
    UniProtKB/TrEMBL
    Q0VF92, Q3V4A6
    Related
    ENSMUSP00000040935.5, ENSMUST00000040826.6
    Conserved Domains (1) summary
    pfam13233
    Location:9 → 105
    Complex1_LYR_2; Complex1_LYR-like

  2. NM_001417719.1 → NP_001404648.1  succinate dehydrogenase assembly factor 3, mitochondrial isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC122240, AC146599

  3. NM_001417720.1 → NP_001404649.1  succinate dehydrogenase assembly factor 3, mitochondrial isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC122240, AC146599

  4. NM_001417721.1 → NP_001404650.1  succinate dehydrogenase assembly factor 3, mitochondrial isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC122240

RNA

  1. NR_184564.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122240
    Related
    ENSMUST00000123848.2

  2. NR_184565.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122240, AC146599

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    6956004..7039661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQU3.1 GenPept UniProtKB/Swiss-Prot:Q8BQU3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous