Gpr15 G protein-coupled receptor 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr15provided by MGI
Official Full Name: G protein-coupled receptor 15provided by MGI
Primary source: MGI:MGI:1918473
See related: Ensembl:ENSMUSG00000047293 AllianceGenome:MGI:1918473
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933439K08Rik
Summary: Enables G protein-coupled receptor activity. Acts upstream of or within T cell migration. Predicted to be located in endosome. Predicted to be active in plasma membrane. Orthologous to human GPR15 (G protein-coupled receptor 15). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 16 C1.2; 16 34.83 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (58537006..58539235, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (58716643..58718872, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology.
Title: Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology.
G Protein-Coupled Receptor 15 Expression Is Associated with Myocardial Infarction.
Title: G Protein-Coupled Receptor 15 Expression Is Associated with Myocardial Infarction.
PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis.
Title: PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis.
The G Protein-Coupled Receptor (GPR) 15 Counteracts Antibody-Mediated Skin Inflammation.
Title: The G Protein-Coupled Receptor (GPR) 15 Counteracts Antibody-Mediated Skin Inflammation.
Study of the role GPR15 L/GPR15 in the Aldara -induced psoriasiform dermatitis and the IL-23-induced dermatitis model in Gpr15-/- mice revealed that in neither model deficiency in Gpr15 modulated disease on the histopathological or the molecular level. Results suggest that significant role of GPR15 in the pathogenesis of psoriasiform dermatitis rather unlikely.
Title: GPR15 is not critically involved in the regulation of murine psoriasiform dermatitis.
we for the first time demonstrated that TM binds to GPR15 via its EGF-like domain and exerts angiogenesis and cytoprotective function in vascular ECs.
Title: G-protein coupled receptor 15 mediates angiogenesis and cytoprotective function of thrombomodulin.
Allotransplantation of skin from Gpr15l-deficient mice onto wild-type mice resulted in substantial graft protection, suggesting nonredundant roles for GPR15 and GPR15L in the generation of effector T cell responses.
Title: A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia.
The fifth epidermal growth factor like region of thrombomodulin exerts anti-inflammatory function by inhibiting NF-kappaB in a GPR15-dependent manner.
Title: The fifth epidermal growth factor like region of thrombomodulin alleviates LPS-induced sepsis through interacting with GPR15.
findings establish a role for GPR15 in skin lymphocyte homing and suggest that it may contribute to lymphocyte subset targeting to diverse epithelial sites.
Title: Orphan chemoattractant receptor GPR15 mediates dendritic epidermal T-cell recruitment to the skin.
findings describe a T cell-homing receptor for large intestine lamina propria and indicate that GPR15 plays a role in mucosal immune tolerance largely by regulating the influx of Tregs
Title: GPR15-mediated homing controls immune homeostasis in the large intestine mucosa.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (5)

General gene information

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Markers

Gpr15 (e-PCR), detects polymorphism
- UniSTS:527365

NoName (e-PCR)
- UniSTS:487464

NoName (e-PCR)
- UniSTS:490698

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G-protein coupled receptor 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.