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Cage1 cancer antigen 1 [ Mus musculus (house mouse) ]

Gene ID: 71213, updated on 5-Mar-2024

Summary

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Official Symbol
Cage1provided by MGI
Official Full Name
cancer antigen 1provided by MGI
Primary source
MGI:MGI:1918463
See related
Ensembl:ENSMUSG00000044566 AllianceGenome:MGI:1918463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ctag3; 4933427I01Rik
Summary
Orthologous to human CAGE1 (cancer antigen 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 17.1) and genital fat pad adult (RPKM 0.4) See more
Orthologs
human all
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Genomic context

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Location:
13 A3.3; 13 17.88 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (38190028..38221115, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (38006052..38037131, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37893604-37893840 Neighboring gene ras responsive element binding protein 1 Neighboring gene predicted gene, 46411 Neighboring gene STARR-positive B cell enhancer ABC_E1461 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37972487-37972670 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37974410-37974611 Neighboring gene STARR-seq mESC enhancer starr_34234 Neighboring gene STARR-positive B cell enhancer ABC_E11541 Neighboring gene STARR-positive B cell enhancer ABC_E7227 Neighboring gene STARR-positive B cell enhancer ABC_E10789 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:38086110-38086293 Neighboring gene predicted gene, 52041 Neighboring gene signal sequence receptor, alpha Neighboring gene STARR-positive B cell enhancer ABC_E9396 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:38129215-38129324 Neighboring gene RIO kinase 1 Neighboring gene STARR-seq mESC enhancer starr_34240 Neighboring gene STARR-seq mESC enhancer starr_34241 Neighboring gene STARR-positive B cell enhancer ABC_E3077 Neighboring gene desmoplakin Neighboring gene small nuclear ribonucleoprotein 48 (U11/U12)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The cancer/testis antigen CAGE-1 is a component of the acrosome of spermatids and spermatozoa. Alsheimer M, et al. Eur J Cell Biol, 2005 Mar. PMID 15819420
  2. CAGE, a cancer/testis antigen, induces c-FLIP(L) and Snail to enhance cell motility and increase resistance to an anti-cancer drug. Kim Y, et al. Biotechnol Lett, 2009 Jul. PMID 19322522
  3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CAGE was shown to protect cells against celastrol, an anti-cancer agent.
    Title: CAGE, a cancer/testis antigen, induces c-FLIP(L) and Snail to enhance cell motility and increase resistance to an anti-cancer drug.
  2. novel component of the acrosome of mammalian spermatids and spermatozoa
    Title: The cancer/testis antigen CAGE-1 is a component of the acrosome of spermatids and spermatozoa.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC100323

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
cancer-associated gene 1 protein homolog
Names
CAGE-1
CT3 homolog
cancer/testis antigen 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027724.2 → NP_082000.2  cancer-associated gene 1 protein homolog

    See identical proteins and their annotated locations for NP_082000.2

    Status: VALIDATED

    Source sequence(s)
    AK016953, AY695827, BC082568, BX519141
    Consensus CDS
    CCDS26460.1
    UniProtKB/Swiss-Prot
    A6X913, Q5IR70, Q640N7
    Related
    ENSMUSP00000074499.5, ENSMUST00000074969.11
    Conserved Domains (2) summary
    COG0419
    Location:363 → 812
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam15066
    Location:1 → 526
    CAGE1; Cancer-associated gene protein 1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    38190028..38221115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516779.5 → XP_006516842.1  cancer-associated gene 1 protein homolog isoform X4

    Conserved Domains (2) summary
    COG0419
    Location:308 → 748
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam15066
    Location:1 → 526
    CAGE1; Cancer-associated gene protein 1 family

  2. XM_006516776.5 → XP_006516839.1  cancer-associated gene 1 protein homolog isoform X2

    See identical proteins and their annotated locations for XP_006516839.1

    UniProtKB/Swiss-Prot
    A6X913, Q5IR70, Q640N7
    Related
    ENSMUSP00000105862.2, ENSMUST00000110233.8
    Conserved Domains (2) summary
    COG0419
    Location:363 → 812
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam15066
    Location:1 → 526
    CAGE1; Cancer-associated gene protein 1 family

  3. XM_017315602.3 → XP_017171091.1  cancer-associated gene 1 protein homolog isoform X1

    Conserved Domains (2) summary
    TIGR02168
    Location:385 → 691
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15066
    Location:1 → 526
    CAGE1; Cancer-associated gene protein 1 family

  4. XM_036158166.1 → XP_036014059.1  cancer-associated gene 1 protein homolog isoform X8

    Conserved Domains (2) summary
    TIGR02168
    Location:74 → 380
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15066
    Location:1 → 215
    CAGE1; Cancer-associated gene protein 1 family

  5. XM_017315603.3 → XP_017171092.1  cancer-associated gene 1 protein homolog isoform X1

    Conserved Domains (2) summary
    TIGR02168
    Location:385 → 691
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15066
    Location:1 → 526
    CAGE1; Cancer-associated gene protein 1 family

  6. XM_017315604.3 → XP_017171093.1  cancer-associated gene 1 protein homolog isoform X3

    Conserved Domains (2) summary
    TIGR02168
    Location:351 → 657
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15066
    Location:2 → 492
    CAGE1; Cancer-associated gene protein 1 family

  7. XM_030247409.2 → XP_030103269.1  cancer-associated gene 1 protein homolog isoform X7

    Conserved Domains (1) summary
    pfam15066
    Location:1 → 215
    CAGE1; Cancer-associated gene protein 1 family

  8. XM_017315605.3 → XP_017171094.1  cancer-associated gene 1 protein homolog isoform X6

    Conserved Domains (2) summary
    TIGR02168
    Location:279 → 585
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15066
    Location:2 → 420
    CAGE1; Cancer-associated gene protein 1 family

  9. XM_030247408.2 → XP_030103268.1  cancer-associated gene 1 protein homolog isoform X6

    Conserved Domains (2) summary
    TIGR02168
    Location:279 → 585
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15066
    Location:2 → 420
    CAGE1; Cancer-associated gene protein 1 family

  10. XM_030247410.2 → XP_030103270.1  cancer-associated gene 1 protein homolog isoform X7

    Conserved Domains (1) summary
    pfam15066
    Location:1 → 215
    CAGE1; Cancer-associated gene protein 1 family

  11. XM_011244349.4 → XP_011242651.2  cancer-associated gene 1 protein homolog isoform X5

    Conserved Domains (2) summary
    TIGR02168
    Location:385 → 691
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15066
    Location:1 → 526
    CAGE1; Cancer-associated gene protein 1 family

RNA

  1. XR_003950483.2 RNA Sequence

  2. XR_001780816.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5IR70.2 GenPept UniProtKB/Swiss-Prot:Q5IR70

Gene LinkOut

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