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Eri2 exoribonuclease 2 [ Mus musculus (house mouse) ]

Gene ID: 71151, updated on 11-Apr-2024

Summary

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Official Symbol
Eri2provided by MGI
Official Full Name
exoribonuclease 2provided by MGI
Primary source
MGI:MGI:1918401
See related
Ensembl:ENSMUSG00000030929 AllianceGenome:MGI:1918401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Exod1; mKIAA1504; 4933424N09Rik
Summary
Predicted to enable 3'-5'-exoribonuclease activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Orthologous to human ERI2 (ERI1 exoribonuclease family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 4.7), limb E14.5 (RPKM 4.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Eri2 in Genome Data Viewer
Location:
7 F2; 7 64.18 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119383049..119393283, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119783826..119794058, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene UPF0124 protein C13orf31 homolog Neighboring gene acyl-CoA synthetase medium-chain family member 3 Neighboring gene predicted gene, 57786 Neighboring gene RNA exonuclease 5 Neighboring gene STARR-seq mESC enhancer starr_20039 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E3747 Neighboring gene STARR-seq mESC enhancer starr_20040 Neighboring gene LYR motif containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ERI1 exoribonuclease 2
Names
exonuclease domain containing 1
exonuclease domain-containing protein 1
NP_001342033.1
NP_081974.3
XP_006508270.1
XP_006508273.1
XP_030098848.1
XP_030098849.1
XP_036009329.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355104.1 → NP_001342033.1  ERI1 exoribonuclease 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164158
    UniProtKB/TrEMBL
    Q6ZPP5
    Conserved Domains (1) summary
    pfam06839
    Location:364 → 412
    zf-GRF; GRF zinc finger

  2. NM_027698.5 → NP_081974.3  ERI1 exoribonuclease 2 isoform 1

    See identical proteins and their annotated locations for NP_081974.3

    Status: VALIDATED

    Source sequence(s)
    AC164158, AK165163, BY019377
    Consensus CDS
    CCDS40107.1
    UniProtKB/Swiss-Prot
    Q3TUK9, Q5BKS4, Q8C133
    Related
    ENSMUSP00000120547.2, ENSMUST00000150844.3
    Conserved Domains (2) summary
    cd06133
    Location:37 → 230
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    pfam06839
    Location:592 → 640
    zf-GRF; GRF zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    119383049..119393283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242989.2 → XP_030098849.1  ERI1 exoribonuclease 2 isoform X1

    UniProtKB/TrEMBL
    Q6ZPP5
    Conserved Domains (1) summary
    pfam06839
    Location:364 → 412
    zf-GRF; GRF zinc finger

  2. XM_030242988.2 → XP_030098848.1  ERI1 exoribonuclease 2 isoform X1

    UniProtKB/TrEMBL
    Q6ZPP5
    Conserved Domains (1) summary
    pfam06839
    Location:364 → 412
    zf-GRF; GRF zinc finger

  3. XM_006508207.4 → XP_006508270.1  ERI1 exoribonuclease 2 isoform X1

    See identical proteins and their annotated locations for XP_006508270.1

    UniProtKB/TrEMBL
    Q6ZPP5
    Conserved Domains (1) summary
    pfam06839
    Location:364 → 412
    zf-GRF; GRF zinc finger

  4. XM_036153436.1 → XP_036009329.1  ERI1 exoribonuclease 2 isoform X2

    UniProtKB/TrEMBL
    Q6ZPP5
    Conserved Domains (1) summary
    pfam06839
    Location:322 → 369
    zf-GRF; GRF zinc finger

  5. XM_006508210.5 → XP_006508273.1  ERI1 exoribonuclease 2 isoform X3

    UniProtKB/TrEMBL
    D3YW28
    Related
    ENSMUSP00000102133.2, ENSMUST00000106523.8
    Conserved Domains (1) summary
    cd06133
    Location:37 → 230
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

RNA

  1. XR_004934186.1 RNA Sequence

    Related
    ENSMUST00000139192.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BKS4.1 GenPept UniProtKB/Swiss-Prot:Q5BKS4

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